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Clinical data | |
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Trade names | Broncomenal, Deronyl, Finaten, Noleptan, Oleptan, Terion, Tosifar, Tussirama[1] |
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ECHA InfoCard | 100.038.135 ![]() |
Chemical and physical data | |
Formula | C21H24ClN3O3 |
Molar mass | 401.89 g·mol−1 |
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Fominoben is an antitussive agent of the benzanilide class, formerly marketed under the name Noleptan.[2] It binds poorly to the sigma-1 receptor, a receptor activated by many other antitussives.[3] It is reported to have respiratory stimulant activity.[4] Other research has indicated it may be an agonist at the benzodiazepine site of the GABAA receptor.[5] It was introduced in Germany in 1973, in Italy in 1979, and in Japan in 1983.[6]
Adverse effects include appetite suppression, nausea, vomiting, insomnia, irritability, and hallucinations. Rarer side effects include somnolence, dizziness, dry mouth, blurred vision, and urticaria.[7]
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See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators |