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GPR123

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ADGRA1

Identifiers

Aliases

ADGRA1, GPR123, adhesion G protein-coupled receptor A1

External IDs

OMIM: 612302; MGI: 1277167; HomoloGene: 18582; GeneCards: ADGRA1; OMA:ADGRA1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q26.3	Start	133,087,924 bp^[1]
Band	10q26.3	End	133,131,675 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 F4\|7 84.89 cM	Start	139,414,090 bp^[2]
Band	7 F4\|7 84.89 cM	End	139,458,004 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right frontal lobe

Brodmann area 9

cingulate gyrus

anterior cingulate cortex

prefrontal cortex

hypothalamus

lateral nuclear group of thalamus

primary visual cortex

amygdala

ventricular zone

Top expressed in

facial motor nucleus

lumbar subsegment of spinal cord

medial dorsal nucleus

Rostral migratory stream

substantia nigra

lateral geniculate nucleus

medial geniculate nucleus

subiculum

dentate gyrus of hippocampal formation granule cell

amygdala

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity
Cellular component	integral component of membrane membrane postsynaptic density glutamatergic synapse
Biological process	G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84435


52389

Ensembl


ENSG00000197177


ENSMUSG00000025475

UniProt


Q86SQ6


Q8C4G9

RefSeq (mRNA)


NM_001083909 NM_001291085 NM_032422


NM_177469

RefSeq (protein)


NP_001077378 NP_001278014


NP_803420

Location (UCSC)

Chr 10: 133.09 – 133.13 Mb

Chr 7: 139.41 – 139.46 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene.^[5]^[6] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]^[8]^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197177 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025475 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.

^ "Entrez Gene: GPR123 G protein-coupled receptor 123".

^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading[edit]

Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)