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(Top) 1 See also 2 References 3 Further reading

MRGPRX1

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MRGPRX1

Identifiers

Aliases

MRGPRX1, GPCR, MGRG2, MRGX1, SNSR4, MAS related GPR family member X1

External IDs

OMIM: 607227; MGI: 2441674; HomoloGene: 86246; GeneCards: MRGPRX1; OMA:MRGPRX1 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11p15.1\|11	Start	18,933,499 bp^[1]
Band	11p15.1\|11	End	18,939,414 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B4	Start	48,200,713 bp^[2]
Band	7\|7 B4	End	48,207,834 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gonad

lower lobe of lung

skin of thigh

skin of hip

liver

canal of the cervix

skin of abdomen

Top expressed in

zone of skin

lip

muscle of thigh

white adipose tissue

urinary bladder

esophagus

quadriceps femoris muscle

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	signal transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity
Cellular component	plasma membrane membrane integral component of membrane integral component of plasma membrane cell surface
Biological process	acute-phase response G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway response to chloroquine
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


259249


243979

Ensembl


ENSG00000170255


ENSMUSG00000050425

UniProt


Q96LB2


Q3KNA1

RefSeq (mRNA)


NM_147199 NM_001393578


NM_175531

RefSeq (protein)


NP_671732


NP_780740

Location (UCSC)

Chr 11: 18.93 – 18.94 Mb

Chr 7: 48.2 – 48.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mas-related G-protein coupled receptor member X1 is a protein that in humans is encoded by the MRGPRX1 gene.^[5]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170255 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050425 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–32. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509. S2CID 14119088.

^ "Entrez Gene: MRGPRX1 MAS-related GPR, member X1".

Further reading[edit]

Lembo PM, Grazzini E, Groblewski T, et al. (2002). "Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs". Nat. Neurosci. 5 (3): 201–9. doi:10.1038/nn815. PMID 11850634. S2CID 42544746.

Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Galés C, Rebois RV, Hogue M, et al. (2005). "Real-time monitoring of receptor and G-protein interactions in living cells". Nat. Methods. 2 (3): 177–84. doi:10.1038/nmeth743. PMID 15782186. S2CID 22398051.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)