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The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes.[1] As the vertebrate superfamily can be phylogenetically grouped into five main families the GRAFS classification system has been proposed.
GRAFS stands for Glutamate , Rhodopsin , Adhesion , Frizzled /Taste2 , Secretin .[2] They correspond to classical classes C (class C , glutamate), A (rhodopsin-like ), B2 (Secretin receptor family , long N-terminal), F (Frizzled /Smoothened ), and B1+3 (other secretin).[3] Taste2 has more recently considered to be closer to Rhodopsin-like receptors.[4]
See also [ edit ]
References [ edit ]
^ Fredriksson, R; Lagerström, MC; Lundin, LG; Schiöth, HB (June 2003). "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints". Molecular Pharmacology . 63 (6 ): 1256–72. doi :10.1124/mol.63.6.1256 . PMID 12761335 .
^ Krishnan, A; Almén, MS; Fredriksson, R; Schiöth, HB (2012). "The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi" . PLOS ONE . 7 (1 ): e29817. Bibcode :2012PLoSO...729817K . doi :10.1371/journal.pone.0029817 . PMC 3251606 . PMID 22238661 .
^ Nordström KJ, Sällman Almén M, Edstam MM, Fredriksson R, Schiöth HB (September 2011). "Independent HHsearch, Needleman—Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families" . Molecular Biology and Evolution . 28 (9 ): 2471–80. doi :10.1093/molbev/msr061 . PMID 21402729 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=GRAFS&oldid=1212839548 "
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