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1 References  














Guvacine






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From Wikipedia, the free encyclopedia
 


Guvacine
Names
Preferred IUPAC name

1,2,5,6-Tetrahydropyridine-3-carboxylic acid

Identifiers

CAS Number

3D model (JSmol)

ChEMBL
ChemSpider

IUPHAR/BPS

KEGG

PubChem CID

UNII

CompTox Dashboard (EPA)

  • InChI=1S/C6H9NO2/c8-6(9)5-2-1-3-7-4-5/h2,7H,1,3-4H2,(H,8,9)

    Key: QTDZOWFRBNTPQR-UHFFFAOYSA-N

  • InChI=1/C6H9NO2/c8-6(9)5-2-1-3-7-4-5/h2,7H,1,3-4H2,(H,8,9)

    Key: QTDZOWFRBNTPQR-UHFFFAOYAX

  • C1CNCC(=C1)C(=O)O

Properties

Chemical formula

C6H9NO2
Molar mass 127.143 g·mol−1

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Guvacine is an hydrogenated pyridine alkaloid found in areca nuts.[1] It is the N-demethylated derivativeofarecaidine and the product of ester hydrolysisofguvacoline, both of which are also found in areca nuts as well. It is also an inhibitor of gamma-aminobutyric acid uptake. Lime is said to hydrolyse guvacoline to guvacine.[2]

References[edit]

  1. ^ Voigt, V; Laug, L; Zebisch, K; Thondorf, I; Markwardt, F; Brandsch, M (2013). "Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1)". The Journal of Pharmacy and Pharmacology. 65 (4): 582–90. doi:10.1111/jphp.12006. PMID 23488788. S2CID 27577546.
  • ^ Johnston, G. A. R.; Krogsgaard-Larsen, P.; Stephanson, A. (1975). "Betel nut constituents as inhibitors of γ-aminobutyric acid uptake". Nature. 258 (5536): 627–628. Bibcode:1975Natur.258..627J. doi:10.1038/258627a0. ISSN 0028-0836. PMID 1207742. S2CID 4147760.

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Guvacine&oldid=1189403557"

    Categories: 
    Alkaloids
    Beta-Amino acids
    GABA reuptake inhibitors
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    Articles containing unverified chemical infoboxes
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    Articles with short description
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    This page was last edited on 11 December 2023, at 16:33 (UTC).

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