Contents

HLA-DMB

Protein-coding gene in the species Homo sapiens

HLA-DMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HDM, 2BC4, 4FQX, 4GBX, 4I0P
Identifiers
Aliases	HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta
External IDs	OMIM: 142856; MGI: 95922; HomoloGene: 68231; GeneCards: HLA-DMB; OMA:HLA-DMB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,934,629 bp[1] End 32,941,028 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,372,046 bp[2] End 34,379,204 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte lymph node appendix spleen duodenum gallbladder right lung upper lobe of left lung rectum Top expressed in mesenteric lymph nodes spleen blood right kidney ankle joint superior surface of tongue thymus sciatic nerve lip subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC class II protein complex binding protein binding Cellular component lysosomal membrane lysosome membrane endosome late endosome membrane integral component of membrane MHC class II protein complex Biological process positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell antigen processing and presentation MHC class II protein complex assembly positive regulation of T cell proliferation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II peptide antigen assembly with MHC class II protein complex immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II immune response adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3109 14999 Ensembl ENSG00000241674 ENSG00000226264 ENSG00000242574 ENSG00000239329 ENSG00000234154 ENSG00000242386 ENSG00000242092 ENSG00000241296 ENSMUSG00000079547 UniProt P28068 P35737 Q31094 RefSeq (mRNA) NM_002118 NM_010387 RefSeq (protein) NP_002109 NP_034517 Location (UCSC) Chr 6: 32.93 – 32.94 Mb Chr 17: 34.37 – 34.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.^[5][6]

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26–28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.^[6]

HLA-DMB is upregulated in tumor tissue of Caucasian but not African patients. Its role in tumor immunology is undefined but has been shown to positively correlated with increased T-cell infiltration and improved prognosis in ovarian cancer. Differential immune processes mediated by HLA-DMB may contribute to the disparity in cancer outcome.^[7]