Contents

HLA-DPB1

Protein-coding gene in the species Homo sapiens

HLA-DPB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3LQZ, 4P4K, 4P4R, 4P57, 4P5K, 4P5M
Identifiers
Aliases	HLA-DPB1, DPB1, HLA-DP, HLA-DP1B, HLA-DPB, major histocompatibility complex, class II, DP beta 1
External IDs	OMIM: 142858; HomoloGene: 129927; GeneCards: HLA-DPB1; OMA:HLA-DPB1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,075,990 bp[1] End 33,089,696 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node appendix monocyte gallbladder spleen upper lobe of left lung right lung duodenum right coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi network membrane endoplasmic reticulum membrane membrane Golgi membrane plasma membrane transport vesicle membrane MHC class II protein complex cell surface lysosomal membrane endoplasmic reticulum ER to Golgi transport vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane Biological process antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II interferon-gamma-mediated signaling pathway immune system process T cell costimulation positive regulation of interferon-gamma production antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of T cell activation positive regulation of T cell proliferation immune response T cell receptor signaling pathway adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3115 n/a Ensembl ENSG00000236693 ENSG00000230708 ENSG00000229295 ENSG00000226826 ENSG00000215048 ENSG00000223865 ENSG00000230763 ENSG00000237710 n/a UniProt P04440 n/a RefSeq (mRNA) NM_002121 n/a RefSeq (protein) NP_002112 n/a Location (UCSC) Chr 6: 33.08 – 33.09 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene.

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.^[3]

See also[edit]

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DP

References[edit]

Further reading[edit]

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