Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]
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: CS1 maint: DOI inactive as of April 2024 (link)This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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