Contents

ILF2

Protein-coding gene in the species Homo sapiens

ILF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AT7, 4AT8, 4AT9, 4ATB
Identifiers
Aliases	ILF2, NF45, PRO3063, interleukin enhancer binding factor 2
External IDs	OMIM: 603181; MGI: 1915031; HomoloGene: 26894; GeneCards: ILF2; OMA:ILF2 - orthologs
Gene location (Mouse) Chr. Chromosome 3 (mouse)[1] Band 3|3 F1 Start 90,383,433 bp[1] End 90,395,686 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence islet of Langerhans anterior pituitary rectum body of pancreas skin of abdomen left lobe of thyroid gland left uterine tube right lobe of thyroid gland right adrenal gland Top expressed in ventricular zone tail of embryo genital tubercle ganglionic eminence neural tube abdominal wall medial ganglionic eminence neural layer of retina epiblast embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding double-stranded RNA binding protein binding ATP binding RNA binding Cellular component cytoplasm nucleolus membrane nucleus specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen extracellular region ribonucleoprotein complex Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated immune response transcription, DNA-templated neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3608 67781 Ensembl n/a ENSMUSG00000001016 UniProt Q12905 Q9CXY6 RefSeq (mRNA) NM_004515 NM_001267809 NM_026374 RefSeq (protein) NP_001254738 NP_004506 NP_080650 Location (UCSC) n/a Chr 3: 90.38 – 90.4 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.^[4][5]

Function[edit]

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.^[5]

Interactions[edit]

ILF2 has been shown to interact with CDC5L^[6] and DNA-PKcs.^[7]

ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,^[8][9] in canine systemic rheumatic autoimmune disease,^[10][11] and as a rare finding in humans with autoimmune disease.^[12]

References[edit]

Further reading[edit]

External links[edit]

• ILF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Interleukin enhancer-binding factor 2 (ILF2)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.