Contents

Interleukin 13 receptor, alpha 1

Protein-coding gene in the species Homo sapiens

IL13RA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BPN, 3BPO, 4HWB, 5E4E
Identifiers
Aliases	IL13RA1, CD213A1, IL-13Ra, NR4, CT19, interleukin 13 receptor subunit alpha 1
External IDs	OMIM: 300119; MGI: 105052; HomoloGene: 1198; GeneCards: IL13RA1; OMA:IL13RA1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 118,727,133 bp[1] End 118,794,535 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A3.3|X 20.49 cM Start 35,375,763 bp[2] End 35,434,912 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium Achilles tendon parietal pleura visceral pleura synovial joint germinal epithelium epithelium of nasopharynx rectum monocyte mucosa of sigmoid colon Top expressed in jejunum left colon duodenum Paneth cell skin of external ear right kidney renal corpuscle proximal tubule ileum granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity protein binding interleukin-13 receptor activity cytokine binding Cellular component integral component of membrane interleukin-13 receptor complex plasma membrane membrane external side of plasma membrane receptor complex Biological process cell surface receptor signaling pathway cytokine-mediated signaling pathway interleukin-13-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3597 16164 Ensembl ENSG00000131724 ENSMUSG00000017057 UniProt P78552 O09030 RefSeq (mRNA) NM_001560 NM_133990 RefSeq (protein) NP_001551 NP_598751 Location (UCSC) Chr X: 118.73 – 118.79 Mb Chr X: 35.38 – 35.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.^[5]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.^[5]

IL13RA1 expression has been linked to higher survival rates for lung cancer patients.^[6]

See also[edit]

• Interleukin-13 receptor

References[edit]

Further reading[edit]

External links[edit]

• IL13RA1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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