Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]
ITGA6 has been shown to interact with TSPAN4[7] and GIPC1.[8]
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Alpha |
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Beta |
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Dimers |
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see also cell surface receptor deficiencies |
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