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IQCB1

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IQCB1

Identifiers

Aliases

IQCB1, NPHP5, PIQ, SLSN5, IQ motif containing B1

External IDs

OMIM: 609237; MGI: 2443764; HomoloGene: 8766; GeneCards: IQCB1; OMA:IQCB1 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q13.33\|3q21.1	Start	121,769,761 bp^[1]
Band	3q13.33\|3q21.1	End	121,835,079 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B3	Start	36,648,747 bp^[2]
Band	16\|16 B3	End	36,693,083 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

epithelium of nasopharynx

testicle

monocyte

ventricular zone

body of pancreas

Achilles tendon

olfactory zone of nasal mucosa

rectum

bronchial epithelial cell

Top expressed in

neural layer of retina

genital tubercle

hand

zygote

spermatocyte

tail of embryo

dentate gyrus of hippocampal formation granule cell

neural tube

ventricular zone

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	enzyme binding protein binding calmodulin binding
Cellular component	cytoplasm microtubule organizing center cytosol centrosome photoreceptor outer segment extracellular exosome cytoskeleton photoreceptor connecting cilium centriole nucleoplasm microtubule cytoskeleton intercellular bridge mitotic spindle
Biological process	photoreceptor cell maintenance maintenance of animal organ identity cell projection organization cilium assembly ciliary basal body-plasma membrane docking
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9657


320299

Ensembl


ENSG00000173226


ENSMUSG00000022837

UniProt


Q15051


Q8BP00

RefSeq (mRNA)


NM_001023570 NM_001023571 NM_001319107 NM_014642


NM_177128

RefSeq (protein)


NP_001018864 NP_001018865 NP_001306036


NP_796102

Location (UCSC)

Chr 3: 121.77 – 121.84 Mb

Chr 16: 36.65 – 36.69 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.^[5]^[6]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173226 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022837 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, De Paepe A, Reinhardt R, Klages S, Tsuda M, Kawakami I, Kusakabe T, Omran H, Imm A, Tippens M, Raymond PA, Hill J, Beales P, He S, Kispert A, Margolis B, Williams DS, Swaroop A, Hildebrandt F (Feb 2005). "Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin". Nat Genet. 37 (3): 282–8. doi:10.1038/ng1520. PMID 15723066. S2CID 4972004.

^ "Entrez Gene: IQCB1 IQ motif containing B1".

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

Mollet G, Salomon R, Gribouval O, et al. (2002). "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin". Nat. Genet. 32 (2): 300–5. doi:10.1038/ng996. PMID 12244321. S2CID 24216974.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Mollet G, Silbermann F, Delous M, et al. (2005). "Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes". Hum. Mol. Genet. 14 (5): 645–56. doi:10.1093/hmg/ddi061. PMID 15661758.

le Maire A, Weber T, Saunier S, et al. (2006). "Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis". Proteins. 59 (2): 347–55. doi:10.1002/prot.20344. PMID 15723349. S2CID 37333782.

Luo X, He Q, Huang Y, Sheikh MS (2006). "Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers". Cancer Res. 65 (23): 10725–33. doi:10.1158/0008-5472.CAN-05-1132. PMID 16322217.

v t e Ciliary proteins
Nephrocystin	NPHP1 INVS NPHP3 NPHP4 IQCB1 CEP290 GLIS2 RPGRIP1L
Basal body	BBsome BBS1 BBS2 BBS4 BBS5 BBS7 TTC8 BBS9 chaperone MKKS BBS10 BBS12 Other ARL6 TRIM32 ALMS1 CC2D2A CEP290 MKS1 RPGRIP1L OFD1 AHI1 INVS NPHP4 NEK8 NPHP1
Cilia	connecting cilia LCA5 RP1 RPGR RPGRIP1 TULP1 primary cilia ARL13B INPP5E IQCB1 PKHD1 PKD1 PKD2 TMEM67
Dynein	outer dynein arms DNAH5 DNAI2 DNAL1 axoneme DNAH11 DNAI1
Radial spokes	RSPH1 RSPH3 RSPH4A RSPH6A RSPH9 RSPH10B
Other	cytoplasm KTU nucleus GLIS2 intraflagellar transport IFT80 other AHI1 ARL13B BRCC3 INPP5E KIF3A LRRC50 SDCCAG8 TMEM216 TXNDC3
see also: ciliopathy

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