ITGA9 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | ITGA9, ALPHA-RLC, ITGA4L, RLC, integrin subunit alpha 9 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603963; MGI: 104756; HomoloGene: 1664; GeneCards: ITGA9; OMA:ITGA9 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene.[5][6][7] Cytogenetic location: 3p22.2 [8]
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.[7]
The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell adhesion with various ligands in the extracellular matrix (ECM), including extra domain A (EDA) fibronectin, tenascin-C, ADAMs, EMELIN1, osteopontin, and VEGF.[9] α9β1 binding is independent of the RGD peptide sequence.
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Alpha |
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Beta |
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Dimers |
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see also cell surface receptor deficiencies |
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