J u m p t o c o n t e n t
M a i n m e n u
M a i n m e n u
N a v i g a t i o n
● M a i n p a g e
● C o n t e n t s
● C u r r e n t e v e n t s
● R a n d o m a r t i c l e
● A b o u t W i k i p e d i a
● C o n t a c t u s
● D o n a t e
C o n t r i b u t e
● H e l p
● L e a r n t o e d i t
● C o m m u n i t y p o r t a l
● R e c e n t c h a n g e s
● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t
● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t
● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e
● C o n t r i b u t i o n s
● T a l k
( T o p )
1
E x a m p l e s
2
S e e a l s o
3
R e f e r e n c e s
4
E x t e r n a l l i n k s
T o g g l e t h e t a b l e o f c o n t e n t s
I m m u n o g l o b u l i n d o m a i n
7 l a n g u a g e s
● G a l e g o
● I t a l i a n o
● М а к е д о н с к и
● 日 本 語
● P o l s k i
● С р п с к и / s r p s k i
● S r p s k o h r v a t s k i / с р п с к о х р в а т с к и
E d i t l i n k s
● A r t i c l e
● T a l k
E n g l i s h
● R e a d
● E d i t
● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d
● E d i t
● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e
● R e l a t e d c h a n g e s
● U p l o a d f i l e
● S p e c i a l p a g e s
● P e r m a n e n t l i n k
● P a g e i n f o r m a t i o n
● C i t e t h i s p a g e
● G e t s h o r t e n e d U R L
● D o w n l o a d Q R c o d e
● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F
● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
( R e d i r e c t e d f r o m I m m u n o g l o b u l i n f o l d )
The immunoglobulin domain , also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,[1] [2] consisting of about 125 amino acids.
The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.
Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies , the giant muscle kinase titin , and receptor tyrosine kinases . Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions.[3]
Examples [ edit ]
Human genes encoding proteins containing the immunoglobulin domain include:
ACAM
ADAMTSL1
ADAMTSL3
AGER
ALCAM
AMIGO1
AMIGO2
AXL
BCAM
BOC
BSG
BTLA
C10orf72
C20orf102
CADM1
CADM3
CD200
CD22
CD276
CD33
CD4
CDON
CEACAM1
CEACAM16
CEACAM20
CEACAM21
CEACAM5
CEACAM6
CEACAM8
CHL1
CILP
CNTFR
CNTN1
CNTN2
CNTN3
CNTN4
CNTN5
CNTN6
CSF1R
DSCAM
DSCAML1
EMB
F11R
FAIM3
FCAR
FCER1A
FCGR1A
FCGR2A
FCGR2B
FCGR2C
FCGR3A
FCGR3B
FCRH1
FCRH3
FCRH4
FCRL1
FCRL2
FCRL3
FCRL4
FCRL5
FCRL6
FCRLA
FGFR1
FGFR2
FGFR3
FGFR4
FGFRL1
FLT1
FLT3
FLT4
FSTL4
FSTL5
GP6
GPA33
GPR116
GPR125
HEPACAM
HLA-DMA
HLA-DMB
HLA-DQB
HLA-DQB1
HMCN1
HNT
HSPG2
HYST2477
ICAM3
ICAM5
IGHA1
IGHD
IGHE
IGSF10
IGSF11
IGSF2
IGSF21
IGSF3
IGSF9
IL11RA
IL1R1
IL1R2
IL1RAPL1
IL1RAPL2
IL1RL1
IL1RL2
IL6R
JAM2
JAM3
KIR-123FM
KIR2DL1
KIR2DL2
KIR2DL3
KIR2DL4
KIR2DL5A
KIR2DL5B
KIR2DLX
KIR2DS1
KIR2DS2
KIR2DS3
KIR2DS4
KIR2DS5
KIR3DL1
KIR3DL2
KIR3DL3
KIR3DS1
KIT
L1CAM
LAG3
LILRA1
LILRA2
LILRA3
LILRA4
LILRA5
LILRA6
LILRB1
LILRB2
LILRB3
LILRB4
LILRB5
LILRP2
LRIG1
LRIG2
LRIG3
LRIT1
LRRC4
LSAMP
MAG
MALT1
MCAM
MDGA1
MDGA2
MERTK
MFAP3
MIR
MIR
MXRA5
MYBPC3
MYOM1
MYOM3
NCA
NCAM1
NCAM2
NEGR1
NEO1
NFASC
NOPE
NPHS1
NPTN
NRCAM
NRG1
NT
NTRK3
OBSCN
OBSL1
OPCML
PAPLN
PDGFRA
PDGFRB
PDGFRL
PECAM1
PRODH2
PSG1
PSG10
PSG11
PSG11s'
PSG2
PSG3
PSG4
PSG5
PSG6
PSG7
PSG8
PSG9
PTGFRN
PTK7
PTPRD
PTPRK
PTPRM
PTPRS
PTPsigma
PUNC
PVR
PVRL1
PVRL2
PVRL4
RAGE
SCN1B
SDK1
SDK2
SEMA3A
SEMA3B
SEMA3E
SEMA3F
SEMA3G
SEMA4D
SIGLEC1
SIGLEC10
SIGLEC11
SIGLEC12
SIGLEC14
SIGLEC6
SIGLEC7
SIGLEC8
SIRPG
THY1
TIE1
TMIGD1
TMIGD2
TTN
TYRO3
UNC5D
VCAM1
VSIG1
VSIG2
VSIG4
hEMMPRIN
kir3d
See also [ edit ]
References [ edit ]
^ Bork P, Holm L, Sander C (September 1994). "The immunoglobulin fold. Structural classification, sequence patterns and common core". J. Mol. Biol . 242 (4 ): 309–20. doi :10.1006/jmbi.1994.1582 . PMID 7932691 .
^ Brümmendorf T, Rathjen FG (1995). "Cell adhesion molecules 1: immunoglobulin superfamily". Protein Profile . 2 (9 ): 963–1108. PMID 8574878 .
^ Williams AF, Barclay AN (1988). "The immunoglobulin superfamily—domains for cell surface recognition". Annu. Rev. Immunol . 6 : 381–405. doi :10.1146/annurev.iy.06.040188.002121 . PMID 3289571 .
External links [ edit ]
t
e
General
All-α folds:
All-β folds:
α/β folds:
α+β folds:
Irregular folds:
R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Immunoglobulin_domain&oldid=1214980189 "
C a t e g o r i e s :
● P r o t e i n d o m a i n s
● P r o t e i n f o l d s
● S i n g l e - p a s s t r a n s m e m b r a n e p r o t e i n s
● T h i s p a g e w a s l a s t e d i t e d o n 2 2 M a r c h 2 0 2 4 , a t 1 1 : 5 3 ( U T C ) .
● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n .
● P r i v a c y p o l i c y
● A b o u t W i k i p e d i a
● D i s c l a i m e r s
● C o n t a c t W i k i p e d i a
● C o d e o f C o n d u c t
● D e v e l o p e r s
● S t a t i s t i c s
● C o o k i e s t a t e m e n t
● M o b i l e v i e w