Contents

KCNJ3

Protein-coding gene in the species Homo sapiens

KCNJ3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N9P, 1U4E, 2QKS, 3K6N
Identifiers
Aliases	KCNJ3, GIRK1, KGA, KIR3.1, potassium voltage-gated channel subfamily J member 3, potassium inwardly rectifying channel subfamily J member 3
External IDs	OMIM: 601534; MGI: 104742; HomoloGene: 1687; GeneCards: KCNJ3; OMA:KCNJ3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.1 Start 154,697,855 bp[1] End 154,858,354 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 55,435,970 bp[2] End 55,598,145 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus cerebellar cortex cerebellar hemisphere cerebellar vermis postcentral gyrus right hemisphere of cerebellum primary visual cortex superior frontal gyrus Top expressed in lobe of cerebellum lateral geniculate nucleus dentate gyrus of hippocampal formation granule cell cerebellar vermis superior frontal gyrus subiculum medial geniculate nucleus medial dorsal nucleus atrium lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein activated inward rectifier potassium channel activity protein binding inward rectifier potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Cellular component integral component of membrane T-tubule cell surface plasma membrane membrane external side of plasma membrane voltage-gated potassium channel complex parallel fiber to Purkinje cell synapse integral component of presynaptic membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport response to electrical stimulus regulation of heart rate by cardiac conduction membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential ventricular cardiac muscle cell membrane repolarization potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3760 16519 Ensembl ENSG00000162989 ENSMUSG00000026824 UniProt P48549 P63250 RefSeq (mRNA) NM_002239 NM_001260508 NM_001260509 NM_001260510 NM_008426 NM_001304810 NM_001355118 RefSeq (protein) NP_001247437 NP_001247438 NP_001247439 NP_002230 NP_001291739 NP_032452 NP_001342047 Location (UCSC) Chr 2: 154.7 – 154.86 Mb Chr 2: 55.44 – 55.6 Mb PubMed search [3] [4]
Wikidata
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G protein-activated inward rectifier potassium channel 1 (GIRK-1) is encoded in the human by the gene KCNJ3.^[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex.^[5]

Interactions[edit]

KCNJ3 has been shown to interact with KCNJ5.^[6][7]

See also[edit]

• G protein-coupled inwardly-rectifying potassium channel
• Inward-rectifier potassium ion channel

References[edit]

Further reading[edit]

External links[edit]

• KCNJ3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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