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(Top) 1 See also 2 References

LPK-26

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LPK-26

Identifiers

2-(3,4-dichlorophenyl)-N-[(2S)-1-(2,5-dihydropyrrol-1-yl)-3-methylbutan-2-yl]-N-methylacetamide

492451-07-7^Y

10043746

8219310^N

HTE2K3D35Y

CompTox Dashboard (EPA)

DTXSID501018433

Chemical and physical data

C₁₈H₂₄Cl₂N₂O

355.30 g·mol⁻¹

3D model (JSmol)

Interactive image

CC(C)[C@@H](CN1CC=CC1)N(C)C(=O)CC2=CC(=C(C=C2)Cl)Cl

InChI=1S/C18H24Cl2N2O/c1-13(2)17(12-22-8-4-5-9-22)21(3)18(23)11-14-6-7-15(19)16(20)10-14/h4-7,10,13,17H,8-9,11-12H2,1-3H3/t17-/m1/s1^N

Key:QFAIAMMFKKYCTL-QGZVFWFLSA-N^N

^NY (what is this?) (verify)

LPK-26 is a potent and selective κ-opioid agonist, and has analgesic effects.^[1]

See also[edit]

U-50488

References[edit]

^ Tao YM, Li QL, Zhang CF, Xu XJ, Chen J, Ju YW, Chi ZQ, Long YQ, Liu JG (April 2008). "LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential". European Journal of Pharmacology. 584 (2–3): 306–11. doi:10.1016/j.ejphar.2008.02.028. PMID 18353307.

Opioid receptor modulators

μ-opioid
(MOR)

Agonists
(abridged;
full list)

3-HO-PCP

7-Acetoxymitragynine

7-Hydroxymitragynine

α-Chlornaltrexamine

Acetyldihydrocodeine

Adrenorphin (metorphamide)

Benzhydrocodone

Chloroxymorphamine

Desmetramadol (desmethyltramadol)

Dextropropoxyphene (propoxyphene)

Dimethylaminopivalophenone

Diamorphine (heroin)

Dihydroetorphine

Dihydromorphine

Dinalbuphine sebacate

Furanylfentanyl

Levacetylmethadol

Met-enkephalin (metenkefalin)

Mitragynine pseudoindoxyl

Oxymorphonazine

Oxymorphone phenylhydrazone

Papaver somniferum (opium)

Pethidine (meperidine)

Tetrahydropapaveroline

Antagonists

(3S,4S)-Picenadol

2-(S)-N,N-(R)-Viminol

4-Caffeoyl-1,5-quinide

4′-Hydroxyflavanone

4',7-Dihydroxyflavone

6β-Naltrexol-d4

β-Chlornaltrexamine

β-Funaltrexamine

Catechin gallate

CTAP

Diacetylnalorphine

Methylnaltrexone

Methylsamidorphan chloride

Nalodeine (N-allylnorcodeine)

Nalorphine dinicotinate

δ-opioid
(DOR)

Agonists

3CS-nalmefene

ADL-5747 (PF-04856881)

Alazocine (SKF-10047)

AR-M100390 (ARM390)

Desmethylclozapine

Desmetramadol (desmethyltramadol)

Diamorphine (heroin)

Dihydroetorphine

Dihydromorphine

Ethylketazocine

Met-enkephalin (metenkefalin)

Mitragynine pseudoindoxyl

N-Phenethyl-14-ethoxymetopon

Norbuprenorphine

Pethidine (meperidine)

TAN-67 (SB-205,607)

Thiobromadol (C-8813)

Antagonists

4',7-Dihydroxyflavone

6β-Naltrexol-d4

β-Chlornaltrexamine

Catechin gallate

Diacetylnalorphine

Methylnaltrexone

Methylnaltrindole

N-Benzylnaltrindole

κ-opioid
(KOR)

Agonists

3CS-nalmefene

14-Methoxymetopon

β-Chlornaltrexamine

β-Funaltrexamine

Adrenorphin (metorphamide)

Alazocine (SKF-10047)

Desmetramadol (desmethyltramadol)

Diamorphine (heroin)

Diacetylnalorphine

Dihydroetorphine

Dihydromorphine

Dinalbuphine sebacate

Dynorphin B (rimorphin)

Ethylketazocine

Leumorphin (dynorphin B-29)

Nalodeine (N-allylnorcodeine)

Norbuprenorphine

Norbuprenorphine-3-glucuronide

Pethidine (meperidine)

Salvinorin A (salvia)

Salvinorin B ethoxymethyl ether

Salvinorin B methoxymethyl ether

Spiradoline (U-62,066)

Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)

Antagonists

4′-Hydroxyflavanone

4',7-Dihydroxyflavone

6β-Naltrexol-d4

β-Chlornaltrexamine

Buprenorphine/samidorphan

Binaltorphimine

Catechin gallate

CERC-501 (LY-2456302)

Methylnaltrexone

N-Fluoropropyl-JDTic

Norbinaltorphimine

Nociceptin
(NOP)

Agonists

(Arg14,Lys15)Nociceptin

((pF)Phe⁴)Nociceptin(1-13)NH₂

(Phe¹Ψ(CH₂-NH)Gly²)Nociceptin(1-13)NH₂

Ac-RYYRWK-NH₂

Ac-RYYRIK-NH₂

Dihydroetorphine

Nociceptin (orphanin FQ)

Nociceptin (1-11)

Nociceptin (1-13)NH₂

Norbuprenorphine

Sunobinop (S-117957)

Antagonists

(Nphe¹)Nociceptin(1-13)NH₂

BTRX-246040 (LY-2940094)

Nociceptin (1-7)

Others

Enkephalinase inhibitors: Amastatin

D-Phenylalanine

Dexecadotril (retorphan)

Ecadotril (sinorphan)

Racecadotril (acetorphan)

Ubenimex (bestatin)

Propeptides: β-Lipotropin (proendorphin)
Prodynorphin
Proenkephalin
Pronociceptin
Proopiomelanocortin (POMC)

Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)

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Retrieved from "https://en.wikipedia.org/w/index.php?title=LPK-26&oldid=1176197831" Categories: ●Acetamides ●Kappa-opioid receptor agonists ●Chloroarenes ●Pyrrolidines ●Synthetic opioids ●Analgesic stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●Articles with changed ChemSpider identifier ●ECHA InfoCard ID from Wikidata ●Articles with changed InChI identifier ●Articles without EBI source ●Chemical pages without DrugBank identifier ●Articles without KEGG source ●Drugs missing an ATC code ●Drugs with no legal status ●Drugboxes which contain changes to verified fields ●All stub articles ●This page was last edited on 20 September 2023, at 04:02 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view