Thiorphan
Clinical data
Identifiers
(±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
PubChem CID
N
YCompTox Dashboard (EPA)
Chemical and physical data
C12H15NO3S
253.32 g·mol−1
3D model (JSmol)
C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) Y
Key:LJJKNPQAGWVLDQ-UHFFFAOYSA-N Y
Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1][2]
Rehydration
Intestinal anti-infectives
Intestinal adsorbents
Intestinal anti-inflammatory agents
Antidiarrheal micro-organisms
Other antidiarrheals
μ-opioid
(MOR)
Antagonists
δ-opioid
(DOR)
Antagonists
κ-opioid
(KOR)
Antagonists
Nociceptin
(NOP)
Antagonists
Others
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