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Laurence Hurst

Laurence Hurst FRS FMedSci
Hurst in 2015
Born	Laurence Daniel Hurst (1965-01-06) 6 January 1965 (age 59)[8] Ilkley, Yorkshire[8]
Education	Truro School[9][10]
Alma mater	University of Cambridge (BA) University of Oxford (DPhil)
Awards	Royal Society University Research Fellowship (1993) EMBO Member (2004)[1]
Scientific career
Fields	Genetics Evolution[2]
Institutions	University of Bath University of Oxford University of Cambridge Harvard University
Thesis	Intra-genomic conflict and evolution (1991)
Doctoral advisor	W. D. Hamilton[3] Alan Grafen[4][5]
Doctoral students	Gilean McVean[6][7]
Website	go.bath.ac.uk/ldhurst

Laurence Daniel Hurst (born 6 January 1965)^[8] FRS FMedSci^[11] is a Professor of Evolutionary Genetics in the Department of Biology and Biochemistry at the University of Bath^[12] and the director of the Milner Centre for Evolution.^{[13][14][15][16]}

Education[edit]

Hurst was educated at Truro School^[8][9][10] and the University of Cambridge where he studied the Natural Sciences TriposatChurchill College, Cambridge, graduating with a Bachelor of Arts degree in 1987.^[17] After a year at Harvard University he returned to the UK, and was awarded a Doctor of Philosophy (DPhil) degree from the University of Oxford in 1991^[5] for research supervised by W. D. Hamilton and Alan Grafen.^[5]

Career and Research[edit]

Hurst was a Royal Society University Research Fellow at the University of Cambridge from 1993 to 1996^{[citation needed]} and has been a professor at the University of Bath since 1997.^[8]

His research interests^[2] include evolution, genetics and genomics using computational and mathematical techniques to understand the way genes and genomes evolve. This has resulted in work on housekeeping genes,^[18] gene orders,^[19][20] and the evolution of drug resistanceinStaphylococcus aureus,^[21] Saccharomyces cerevisiae^[22][23][24] and the evolution of sexual reproduction / sexual dimorphism.^[25]

Hurst works on fundamental problems in the evolution of genetic systems, such as understanding why some sorts of mutations are less damaging than predicted whilst others are more damaging. Mutations that change proteins are, surprisingly, often not especially deleterious. Hurst showed that this was because the genetic code is structured in a way that renders it highly error-proof. Similarly, in applying network representations of gene interactions, he revealed why many deletions of genes have little effect and which deletions tend not to be recessive.^[11]

By contrast, Hurst revealed that genomic changes often considered to be relatively harmless – such as gene order changes and mutations at 'silent' sites – are under selection for unanticipated reasons. He also showed how synonymous mutations can disrupt the way gene transcripts are processed. Similarly, in showing that genomes are arranged into gene expression domains, Hurst revealed that genes can affect the expression of other genes in their vicinity. As of 2015^[update] translation of this fundamental work to medicine is a focus of his research.^[11]

Awards and honours[edit]

Hurst was elected a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society (FRS) in 2015.^[11] His certificate of election to the Royal Society reads:

Hurst is a leading authority on evolution of genetic systems. He showed that the genetic code is adapted to minimise errors, synonymous mutations in mammals are under selection and gene order is non-random. He was first to recognise the impact of gene expression levels on protein evolution. Hurst spearheaded novel approaches to evolutionary genetics deriving fitness from underlying biochemistry to predict the outcome of laboratory models. This led to fundamental insights into causes of gene dispensability, dominance and variation in gene family size. Hurst, collaborating with cell biologists, identified the human-specific pluripotency gene network and discovered human naïve stem cells.^[26]

Hurst was awarded the Scientific Medal of the Zoological Society of London in 2003,^[15] and elected a member of European Molecular Biology Organization (EMBO) in 2004.^[1] He was awarded The Genetics Society Medal in 2010.^[16]

References[edit]

1. ^ ^{a b} "Find people in the EMBO Communities". people.embo.org.

^ ^{a b} Laurence Hurst publications indexed by Google Scholar

^ Holden, M. T. G.; Feil, E.; Lindsay, J.; Peacock, S.; Day, N.; Enright, M.; Foster, T.; Moore, C.; Hurst, L.; Atkin, R.; Barron, A.; Bason, N.; Bentley, S. D.; Chillingworth, C.; Chillingworth, T.; Churcher, C.; Clark, L.; Corton, C.; Cronin, A.; Doggett, J.; Dowd, L.; Feltwell, T.; Hance, Z.; Harris, B.; Hauser, H.; Holroyd, S.; Jagels, K.; James, K. D.; Lennard, N.; Line, A. (2004). "Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance". Proceedings of the National Academy of Sciences. 101 (26): 9786–9791. Bibcode:2004PNAS..101.9786H. doi:10.1073/pnas.0402521101. PMC 470752. PMID 15213324.