Linda B. Buck was born in Seattle, Washington on January 29, 1947. Her father was an electrical engineer who spent his time inventing and building different items in his spare time, while her mother was a homemaker who spent a majority of her free time solving word puzzles.[10] Buck was the second of three children, all of them girls.[11] Her father has Irish ancestry as well as ancestors dating back to the American revolution. Her mother is of Swedish ancestry.[12] In 1994 Buck met Roger Brent, also a biologist. The two married in 2006.[13]
In 1980, Buck began postdoctoral research at Columbia University under Benvenuto Pernis (1980–1982). In 1982, she joined the laboratory of Richard Axel, also at Columbia in the Institute of Cancer Research. After reading Sol Snyder's group research paper at Johns Hopkins University, Buck set out to map the olfactory process at the molecular level, tracing the travel of odors through the cells of the nose to the brain. Buck and Axel worked with rat genes in their research and identified a family of genes that code for more than 1000 odor receptors and published these findings in 1991.[6][16] Later that year, Buck became an assistant professor in the Neurobiology Department at Harvard Medical School where she established her own lab.[17] After finding how odors are detected by the nose, Buck published her findings in 1993 on how the inputs from different odor receptors are organized in the nose.[16] Essentially, her primary research interest is on how pheromones and odors are detected in the nose and interpreted in the brain. She is a Full Member of the Basic Sciences Division at Fred Hutchinson Cancer Research Center, and an Affiliate Professor of Physiology and Biophysics at the University of Washington, Seattle.
Nobel Prize in Physiology or Medicine (2004)[edit]
In her landmark paper published in 1991 with Richard Axel, Linda Buck discovered hundreds of genes code for the odorant sensors located in the olfactory neurons of our noses.[15] Each receptor is a protein that changes when an odor attaches to the receptor, causing an electrical signal to be sent to the brain.[11] Differences between odorant sensors mean that certain odors cause a signal to be released from a certain receptor.[11] We are then able to interpret varying signals from our receptors as specific scents.[11] To do this, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors. By analyzing ratDNA, they estimated that there were approximately 1,000 different genes for olfactory receptors in the mammaliangenome.[18][19] This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction. In their later work, Buck and Axel have shown that each olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated glomerulus of the olfactory bulb.
Buck retracted 3 papers, published in Nature (pub. 2001, retracted 2008), Science (pub 2006, retracted 2010) and Proceedings of the National Academy of Sciences (pub 2005, retracted 2010) due to falsification/fabrication of results by lead author and collaborator Zhihua Zou. [23]
