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Contents

   



(Top)
 


1 See also  





2 References  














Liafensine






تۆرکجه
فارسی
 

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Liafensine
Clinical data
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
  • Development terminated
Identifiers
  • 6-[(4S)-2-Methyl-4-(2-naphthyl)-1,2,3,4-tetrahydro-7-isoquinolinyl]-3-pyridazinamine

CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H22N4
Molar mass366.468 g·mol−1
3D model (JSmol)
  • CN1C[C@H](C2=C(C1)C=C(C=C2)C3=NN=C(C=C3)N)C4=CC5=CC=CC=C5C=C4

  • InChI=1S/C24H22N4/c1-28-14-20-13-19(23-10-11-24(25)27-26-23)8-9-21(20)22(15-28)18-7-6-16-4-2-3-5-17(16)12-18/h2-13,22H,14-15H2,1H3,(H2,25,27)/t22-/m0/s1

  • Key:VCIBGDSRPUOBOG-QFIPXVFZSA-N

Liafensine (BMS-820836) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) which was under development by Bristol-Myers Squibb for the treatment of major depressive disorder.[1][2] Though it demonstrated comparable effectiveness to escitalopram and duloxetineinphase II clinical trials, development was paused in 2013 because liafensine failed to show superior effectiveness relative to these drugs, a decision that was made likely based on its increased capacity for side effects as well as potential for abuse.[1] Another clinical trial of liafensine began in 2022.[3]

See also[edit]

References[edit]

  1. ^ a b "Digest". Progress in Neurology and Psychiatry. 17 (5): 41–43. 2013. doi:10.1002/pnp.305. ISSN 1367-7543. S2CID 222168896.
  • ^ Bang-Andersen B, Bøgesø KP, Kehler J, Sánchez C (2017). "New Trends in Antidepressant Drug Research". In Ecker GF, Clausen RP, Sitte HH (eds.). Transporters as drug targets. Methods and Principles in Medicinal Chemistry. Weinheim, Germany: John Wiley & Sons. pp. 21–52 (22). doi:10.1002/9783527679430.ch2. ISBN 978-3-527-33384-4.
  • ^ "CTG Labs - NCBI". clinicaltrials.gov. Retrieved 3 December 2023.

  • t
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  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Liafensine&oldid=1188385373"

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    This page was last edited on 5 December 2023, at 02:17 (UTC).

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