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| Formula | C20H27NO2 |
| Molar mass | 313.441 g·mol−1 |
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RTI(-4229)-150, ((−)-2β-Carbocyclobutoxy-3β-(4-methylphenyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and stimulant drug. It is around 5x more potent than cocaine, but is more selective for the dopamine transporter relative to the other monoamine transporters. RTI-150 has a fast onset of effects and short duration of action, and its abuse potential in animal studies is similar to that of cocaine itself; its main application in scientific research has been in studies investigating the influence of pharmacokinetics on the abuse potential of stimulant drugs, with the rapid entry of RTI-150 into the brain thought to be a key factor in producing its high propensity for development of dependence in animals.[1][2][3] RTI-150 is not explicitly illegal anywhere in the world, but its similar structure and pharmacological activity to cocaine makes it possible that it would be considered a controlled substance analogue in countries such as the US, Canada, Australia and New Zealand which have controlled substance analogue legislation.
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| 2-Carboxymethyl Esters |
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| (3,4-Disubstituted Phenyl)-tropanes |
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| Heterocycles: 3-Substituted-isoxazol-5-yl |
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| Heterocycles: 3-Substituted-1,2,4-oxadiazole |
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| N-replaced (S,O,C) |
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| Irreversible |
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| Nortropanes (N-demethylated) |
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