MRPS5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | MRPS5, MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611972; MGI: 1924971; HomoloGene: 32726; GeneCards: MRPS5; OMA:MRPS5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.[5]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.[5]
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Proteins |
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Other concepts |
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Ribosomal RNA / ribosome subunits
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Archaea (70S) |
Small (30S): | ||||||
Bacteria (70S) |
Small (30S): | ||||||
Eukaryotes |
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Ribosomal proteins | (See article table) |
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