Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Interactions 2 References 3 Further reading

Metallothionein 2A

●Cymraeg ●فارسی ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

MT2A

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
1MHU, 2MHU

Identifiers

Aliases

MT2A, MT2, Metallothionein 2A, MT-II, MT-2

External IDs

OMIM: 156360; HomoloGene: 136536; GeneCards: MT2A; OMA:MT2A - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q13	Start	56,608,584 bp^[1]
Band	16q13	End	56,609,497 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pericardium

right lobe of liver

olfactory bulb

mucosa of transverse colon

left uterine tube

external globus pallidus

cartilage tissue

right lobe of thyroid gland

upper lobe of left lung

Region I of hippocampus proper

n/a

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding zinc ion binding
Cellular component	cytoplasm perinuclear region of cytoplasm cytosol nucleus
Biological process	response to metal ion cellular response to interleukin-3 cellular response to erythropoietin negative regulation of growth cellular response to zinc ion interferon-gamma-mediated signaling pathway cellular copper ion homeostasis cellular zinc ion homeostasis detoxification of copper ion cellular response to cadmium ion cellular response to copper ion nitric oxide mediated signal transduction response to bacterium
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4502


n/a

Ensembl


ENSG00000125148


n/a

UniProt


P02795


n/a

RefSeq (mRNA)


NM_005953


n/a

RefSeq (protein)


NP_005944


n/a

Location (UCSC)

Chr 16: 56.61 – 56.61 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.^[3]^[4]

The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenineinMT2A is associated with certain cancers and some chronic diseases.^[5]

Interactions[edit]

Metallothionein 2A has been shown to interact with protein kinase D1.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125148 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Karin M, Richards RI (Dec 1982). "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene". Nature. 299 (5886): 797–802. Bibcode:1982Natur.299..797K. doi:10.1038/299797a0. PMID 7133118. S2CID 4332683.

^ "Entrez Gene: MT2A metallothionein 2A".

^ Sekovanić A, Jurasović J, Piasek M (2020). "Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans". Arhiv Za Higijenu Rada I Toksikologiju. 71 (1): 27–47. doi:10.2478/aiht-2020-71-3349. PMC 7837243. PMID 32597135.

^ Rao, Prema S; Jaggi Meena; Smith David J; Hemstreet George P; Balaji K C (Oct 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. 310 (3). United States: 1032–8. doi:10.1016/j.bbrc.2003.09.118. ISSN 0006-291X. PMID 14550308.

Further reading[edit]

Kissling MM, Kägi HR (1977). "Primary structure of human hepatic metallothionein". FEBS Lett. 82 (2): 247–50. Bibcode:1977FEBSL..82..247K. doi:10.1016/0014-5793(77)80594-2. PMID 913597. S2CID 46396323.

Yamazaki S, Nakanishi M, Hamamoto T, et al. (1993). "Expression of human metallothionein-II fusion protein in Escherichia coli". Biochem. Int. 28 (3): 451–60. PMID 1339282.

Messerle BA, Schäffer A, Vasák M, et al. (1992). "Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy". J. Mol. Biol. 225 (2): 433–43. doi:10.1016/0022-2836(92)90930-I. PMID 1593628.

Zafarullah M, Martel-Pelletier J, Cloutier JM, et al. (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–72. Bibcode:1992FEBSL.306..169Z. doi:10.1016/0014-5793(92)80992-P. PMID 1633872. S2CID 43460076.

Messerle BA, Schäffer A, Vasák M, et al. (1990). "Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy". J. Mol. Biol. 214 (3): 765–79. doi:10.1016/0022-2836(90)90291-S. PMID 2388267.

Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW (1989). "Changes in brain gene expression shared by scrapie and Alzheimer disease". Proc. Natl. Acad. Sci. U.S.A. 86 (18): 7260–4. Bibcode:1989PNAS...86.7260D. doi:10.1073/pnas.86.18.7260. PMC 298037. PMID 2780570.

Karin M, Haslinger A, Heguy A, et al. (1987). "Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity". Mol. Cell. Biol. 7 (2): 606–13. doi:10.1128/mcb.7.2.606. PMC 365115. PMID 3821726.

Karin M, Haslinger A, Holtgreve H, et al. (1984). "Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene". Nature. 308 (5959): 513–9. Bibcode:1984Natur.308..513K. doi:10.1038/308513a0. PMID 6323998. S2CID 4357363.

Schmidt CJ, Hamer DH, McBride OW (1984). "Chromosomal location of human metallothionein genes: implications for Menkes' disease". Science. 224 (4653): 1104–6. Bibcode:1984Sci...224.1104S. doi:10.1126/science.6719135. PMID 6719135.

Karin M, Richards RI (1982). "Human metallothionein genes: molecular cloning and sequence analysis of the mRNA". Nucleic Acids Res. 10 (10): 3165–73. doi:10.1093/nar/10.10.3165. PMC 320698. PMID 6896577.

Lambert E, Kille P, Swaminathan R (1996). "Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes". FEBS Lett. 389 (2): 210–2. Bibcode:1996FEBSL.389..210L. doi:10.1016/0014-5793(96)00587-X. PMID 8766831. S2CID 8195335.

Woo ES, Dellapiazza D, Wang AS, Lazo JS (1999). "Energy-dependent nuclear binding dictates metallothionein localization". J. Cell. Physiol. 182 (1): 69–76. doi:10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9. PMID 10567918. S2CID 31787611.

Jiang LJ, Vasák M, Vallee BL, Maret W (2000). "Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2503–8. Bibcode:2000PNAS...97.2503J. doi:10.1073/pnas.97.6.2503. PMC 15958. PMID 10716985.

Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.

Ebert MP, Günther T, Hoffmann J, et al. (2000). "Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer". Cancer Res. 60 (7): 1995–2001. PMID 10766190.

Toyama M, Yamashita M, Hirayama N, Murooka Y (2003). "Interactions of arsenic with human metallothionein-2". J. Biochem. 132 (2): 217–21. doi:10.1093/oxfordjournals.jbchem.a003213. PMID 12153718.

Sun X, Kang YJ (2002). "Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity". Exp. Biol. Med. (Maywood). 227 (8): 652–7. doi:10.1177/153537020222700815. PMID 12192109. S2CID 45099558.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.

PDB gallery

1mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

1mrb: THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE

1mrt: CONFORMATION OF CD-7 METALLOTHIONEIN-2 FROM RAT LIVER IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

2mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Metallothionein_2A&oldid=1222460908" Categories: ●Genes on human chromosome 16 ●Human proteins ●Human chromosome 16 gene stubs Hidden categories: ●Articles with short description ●Short description is different from Wikidata ●All stub articles ●This page was last edited on 6 May 2024, at 02:41 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view