Jump to content

Main menu Navigation ●Main page ●Contents ●Current events ●Random article ●About Wikipedia ●Contact us ●Donate Contribute ●Help ●Learn to edit ●Community portal ●Recent changes ●Upload file

●Create account ●Log in ●Create account ● Log in Pages for logged out editors learn more ●Contributions ●Talk

(Top) 1 Interactions 2 Clinical significance 3 References 4 Further reading 5 External links

NME3

●Cymraeg ●Français ●Татарча / tatarça ●Українська Edit links ●Article ●Talk ●Read ●Edit ●View history Tools Actions ●Read ●Edit ●View history General ●What links here ●Related changes ●Upload file ●Special pages ●Permanent link ●Page information ●Cite this page ●Get shortened URL ●Download QR code ●Wikidata item Print/export ●Download as PDF ●Printable version Appearance From Wikipedia, the free encyclopedia

NME3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1ZS6

Identifiers

Aliases

NME3, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2, NME/NM23 nucleoside diphosphate kinase 3

External IDs

OMIM: 601817; MGI: 1930182; HomoloGene: 20562; GeneCards: NME3; OMA:NME3 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p13.3	Start	1,770,320 bp^[1]
Band	16p13.3	End	1,771,561 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17\|17 A3.3	Start	25,115,474 bp^[2]
Band	17\|17 A3.3	End	25,116,496 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

anterior pituitary

right hemisphere of cerebellum

right adrenal gland

left adrenal cortex

right adrenal cortex

right uterine tube

canal of the cervix

gastric mucosa

left uterine tube

muscle layer of sigmoid colon

Top expressed in

bone marrow

pancreas

adrenal gland

islet of Langerhans

urinary bladder

embryo

proximal tubule

right kidney

epiblast

hypothalamus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	kinase activity nucleotide binding transferase activity protein binding ATP binding metal ion binding nucleoside diphosphate kinase activity
Cellular component	cytosol intracellular anatomical structure
Biological process	UTP biosynthetic process apoptotic process CTP biosynthetic process GTP biosynthetic process nucleotide metabolic process nucleoside diphosphate phosphorylation phosphorylation nucleobase-containing small molecule interconversion regulation of apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4832


79059

Ensembl


ENSG00000103024


ENSMUSG00000073435

UniProt


Q13232


Q9WV85

RefSeq (mRNA)


NM_002513


NM_019730

RefSeq (protein)


NP_002504


NP_062704

Location (UCSC)

Chr 16: 1.77 – 1.77 Mb

Chr 17: 25.12 – 25.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[5]^[6]

Interactions[edit]

NME3 has been shown to interact with NME1^[7]^[8] and NME2.^[8]^[9]

Clinical significance[edit]

Mutations in this gene have been associated with congenital hypotonia, hypoventilation and cerebellar histopathological alterations.^[10]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103024 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073435 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (March 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Research. 57 (6): 1180–7. PMID 9067290.

^ "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".

^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

^ ^a ^b Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. hdl:11380/695506. PMID 11042679.

^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

^ Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF (December 2018). "Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder". Proceedings of the National Academy of Sciences of the United States of America. 116 (2): 566–574. doi:10.1073/pnas.1818629116. PMC 6329951. PMID 30587587.

Further reading[edit]

Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B (August 1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7435–9. Bibcode:1995PNAS...92.7435V. doi:10.1073/pnas.92.16.7435. PMC 41354. PMID 7638209.

Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. hdl:11380/695506. PMID 11042679.

Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (March 2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of Sciences of the United States of America. 103 (12): 4717–22. Bibcode:2006PNAS..103.4717S. doi:10.1073/pnas.0600585103. PMC 1450237. PMID 16537434.

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S (October 2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Translational Research. 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID 17900511.

External links[edit]

Overview of all the structural information available in the PDB for UniProt: Q13232 (Nucleoside diphosphate kinase 3) at the PDBe-KB.

v t e PDB gallery
1zs6: structure of human nucleoside-diphosphate kinase 3

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=NME3&oldid=1193533766" Categories: ●Genes on human chromosome 16 ●Human chromosome 16 gene stubs Hidden categories: ●Articles with short description ●Short description matches Wikidata ●All stub articles ●This page was last edited on 4 January 2024, at 08:39 (UTC). ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Mobile view