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Rajesh Vasantlal Thakker OBE FRS FMedSci FRCPath FRCPE FRCP [2] (born 1954) is May Professor of Medicine in the Nuffield Department of Clinical Medicine at the University of Oxford and a fellow of Somerville College, Oxford .[4] Thakker is also a Consultant physician at the Churchill Hospital and the John Radcliffe Hospital , Principal investigator (PI ) at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and was Chairman of the NIHR /MRC Efficacy and Mechanism Evaluation (EME) Board until Spring 2016.[5] [6] [7] [8] [9] [10] [11] [12]
Education
[ edit ]
Thakker was educated at Pembroke College, Cambridge , where he was awarded his Master of Arts (MA ), Bachelor of Medicine, Bachelor of Surgery (MB BChir), Doctor of Medicine (MD ) and Doctor of Science (ScD) degrees. He completed his clinical training at Middlesex Hospital Medical School .[3]
Research and career
[ edit ]
Thakker's research investigates neuroendocrine tumours such as multiple endocrine neoplasia type 1 (MEN1) [2] [11] [13] [14] and the molecular basis of disorders of calcium homeostasis .[7] He has supervised nine successful Doctor of Philosophy students[15] [16] [17] [18] [19] [20] [21] [22] [23] and his research has been funded by the Medical Research Council (MRC) .[24]
Thakker has edited several books including Genetic and Molecular Biological Aspects of Endocrine Disease ,[25] Molecular Genetics of Endocrine Disorders ,[26] and Genetics of Bone Biology and Skeletal Disease .[27]
Awards and honours
[ edit ]
Thakker was elected a Fellow of the Royal Society (FRS) in 2014. His nomination reads:
Thakker has made a sustained series of major contributions to endocrinology , particularly parathyroid and renal disorders affecting calcium homeostasis . His research at the basic-science and clinical interface has resulted in seminal gene discoveries and insights into molecular, cellular and physiological mechanisms. These include: identification of functional pathways of calcium-sensing, through characterisation of mutations of the calcium-sensing-receptor , a G-protein-coupled- receptor (GPCR) , and its signalling pathway through G-protein-alpha-11-subunit (Gα11) and adaptor-protein-2-sigma-subunit (AP2σ) , which regulates GPCR endocytosis ; and defining a molecular-based taxonomy of syndromic and non-syndromic hyperparathyroid and hypoparathyroid disorders that has resulted in new pathophysiological insights and advances in diagnosis and treatment.[28]
Personal life
[ edit ]
Thakker is married to Julie Clare Magee and has one daughter, Clare Thakker, who has qualified as a doctor from Clare College, Cambridge .[3] He is a school governor at Oxford High School, Oxford .[29]
References
[ edit ]
^ a b c d Anon (2014). "Thakker, Prof. Rajesh Vasantlal" . Who's Who (online edition via Oxford University Press ed.). A & C Black. doi :10.1093/ww/9780199540884.013.U37302 . (Subscription or UK public library membership required.)
^ Professor Rajesh Thakker, Somerville College , University of Oxford
^ "EME Programme appoint new Chair of Funding Board" . www.nihr.ac.uk . Archived from the original on 17 September 2016.
^ Prof Rajesh V Thakker , Oxford Centre for Diabetes, Endocrinology and Metabolism OCDEM
^ a b Rajesh Thakker publications indexed by the Scopus bibliographic database. (subscription required)
^ Holmes, David (2013). "Rajesh Thakker: A man of hidden depths" . The Lancet Diabetes & Endocrinology . 1 (4 ): 274. doi :10.1016/S2213-8587(13 )70196-7 . PMID 24622412 .
^ Lloyd, S. E.; Pearce, S. H.; Fisher, S. E.; Steinmeyer, K; Schwappach, B; Scheinman, S. J.; Harding, B; Bolino, A; Devoto, M; Goodyer, P; Rigden, S. P.; Wrong, O; Jentsch, T. J.; Craig, I. W.; Thakker, R. V. (1996). "A common molecular basis for three inherited kidney stone diseases". Nature . 379 (6564): 445–9. Bibcode :1996Natur.379..445L . doi :10.1038/379445a0 . hdl :11858/00-001M-0000-0012-CBFE-2 . PMID 8559248 . S2CID 4364656 .
^ Modlin, I. M.; Oberg, K.; Chung, D. C.; Jensen, R. T.; De Herder, W. W.; Thakker, R. V. ; Caplin, M.; Delle Fave, G.; Kaltsas, G. A.; Krenning, E. P.; Moss, S. F.; Nilsson, O.; Rindi, G.; Salazar, R.; Ruszniewski, P.; Sundin, A. (2008). "Gastroenteropancreatic neuroendocrine tumours". The Lancet Oncology . 9 (1 ): 61–72. doi :10.1016/S1470-2045(07 )70410-2 . PMID 18177818 . S2CID 46127116 .
^ a b Pearce, S. H.; Williamson, C; Kifor, O; Bai, M; Coulthard, M. G.; Davies, M; Lewis-Barned, N; McCredie, D; Powell, H; Kendall-Taylor, P; Brown, E. M.; Thakker, R. V. (1996). "A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor" . The New England Journal of Medicine . 335 (15 ): 1115–22. doi :10.1056/NEJM199610103351505 . PMID 8813042 .
^ Carpten, J. D.; Robbins, C. M.; Villablanca, A; Forsberg, L; Presciuttini, S; Bailey-Wilson, J; Simonds, W. F.; Gillanders, E. M.; Kennedy, A. M.; Chen, J. D.; Agarwal, S. K.; Sood, R; Jones, M. P.; Moses, T. Y.; Haven, C; Petillo, D; Leotlela, P. D.; Harding, B; Cameron, D; Pannett, A. A.; Höög, A; Heath h, 3rd; James-Newton, L. A.; Robinson, B; Zarbo, R. J.; Cavaco, B. M.; Wassif, W; Perrier, N. D.; Rosen, I. B.; et al. (2002). "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nature Genetics . 32 (4 ): 676–80. doi :10.1038/ng1048 . PMID 12434154 . S2CID 23713328 . {{cite journal }}
: CS1 maint: numeric names: authors list (link )
^ Brandi, M. L.; Gagel, R. F.; Angeli, A; Bilezikian, J. P.; Beck-Peccoz, P; Bordi, C; Conte-Devolx, B; Falchetti, A; Gheri, R. G.; Libroia, A; Lips, C. J.; Lombardi, G; Mannelli, M; Pacini, F; Ponder, B. A.; Raue, F; Skogseid, B; Tamburrano, G; Thakker, R. V. ; Thompson, N. W.; Tomassetti, P; Tonelli, F; Wells Jr, S. A.; Marx, S. J. (2001). "Guidelines for diagnosis and therapy of MEN type 1 and type 2" . The Journal of Clinical Endocrinology and Metabolism . 86 (12 ): 5658–71. doi :10.1210/jcem.86.12.8070 . PMID 11739416 .
^ Lemmens, I; Van De Ven, W. J.; Kas, K; Zhang, C. X.; Giraud, S; Wautot, V; Buisson, N; De Witte, K; Salandre, J; Lenoir, G; Pugeat, M; Calender, A; Parente, F; Quincey, D; Gaudray, P; De Wit, M. J.; Lips, C. J.; Höppener, J. W.; Khodaei, S; Grant, A. L.; Weber, G; Kytölä, S; Teh, B. T.; Farnebo, F; Thakker, R. V. (1997). "Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1" . Human Molecular Genetics . 6 (7 ): 1177–83. doi :10.1093/hmg/6.7.1177 . PMID 9215690 .
^ Bowl, Michael Richard (2003). Molecular genetics of hypoparathyroid disorders (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.275359 .
^ Bradley, Karin J. (2006). Molecular genetics of the hyperparathyroidism-jaw tumour syndrome (DPhil thesis). University of Oxford.
^ Gaynor, Katherine Ursula (2011). The role of the transcription factor GATA3 in calcium homeostasis and tumourigenesis (DPhil thesis). University of Oxford.
^ Leotlela, Poloko D. (2003). Molecular genetics of multiple endocrine neoplasia type 1 and related disorders (DPhil thesis). University of Oxford.
^ Loureiro de Lemos, Manuel C. (2007). Genetic and phenotypic studies of the multiple endocrine neoplasia type 1 syndrome (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.445777 .
^ Javid, Mahsa (2012). Gene modifiers and novel therapies for multiple endocrine neoplasia type 1 (DPhil thesis). University of Oxford.
^ Jeyabalan, Jeshmi (2008). Role of sedlin in spondyloepiphyseal dysplasia tarda (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.496979 .
^ Turner, Jeremy James Osborne (2003). Molecular genetics of renal tubular disorders affecting urate transport (DPhil thesis). University of Oxford.
^ Wu, Fiona (2014). Dent's disease and the chloride channel, CLC-5 (DPhil thesis). University of Oxford.
^ UK Government research grants awarded to Rajesh Thakker , via Research Councils UK
^ Thakker, R. V (1995). Genetic and Molecular Biological Aspects of Endocrine Disease . SPCK. ISBN 9780702019456 .
^ Thakker, R. (4 September 1998). Molecular Genetics of Endocrine Disorders . Taylor & Francis. ISBN 9780412589706 .
^ Thakker, R. V; Whyte, Michael P; Eisman, John; Igarashi, Takashi (2013). Genetics of Bone Biology and Skeletal Disease . Academic Press. ISBN 9780123878298 .
^ "Professor Rajesh Thakker FMedSci FRS" . London: The Royal Society. Archived from the original on 5 August 2014.
^ "Oxford High School GDST School Governors" . Archived from the original on 4 July 2014.
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