Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[5][6]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]
It is also required for the uptake of metformin by cells.[7][8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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see also solute carrier disorders |