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iochemically inaccurate - the Aciclo-GTP form is an inhibitor because it is incorporated into nascent DNA resulting in chain termination. SOMETIMES w
hile the residue incorporated will be the GM--68.45.23.238 (talk) 03:44, 24 March 2013 (UTC)P form, it is the GTP form that will be the substrate for the reaction (to drive it forward through pyrophosphate release). Cheers! --163.1.176.25412:40, 30 April 2007 (UTC)[reply]
Great page, guys. Can we move it to the INN aciclovir and have acyclovir redirect there?
Consider it done. JFW | T@lk 20:32, 21 Dec 2004 (UTC)
is acyclovir's inhibitory action through impairment of thymidylate kinase and acts as a competitive inhibitor of normal triphosphate nucleotides thus, can someone clear this up for me? —Preceding unsigned comment added by 193.1.229.15 (talk) 17:21, 31 May 2009 (UTC)[reply]
"Since acyclovir can also be incorporated into cellular DNA, it is a chromosome mutagen, therefore, its use should be avoided during pregnancy". I don't think this is correct. I happen to know that physicians do prescribe aciclovir during pregnancy because an herpes infection can be lethal to the newborn child. Also, aciclovir has a pregnancy category B3 (Au), B (VS) which means it's relatively safe. —Preceding unsigned comment added by 130.89.139.9 (talk) 15:00, 8 October 2009 (UTC)[reply]
This chemical is a guanine analogue, and acts like guanine with some bio-molecules, thus it's action in repressing the virus. It would assist visualizing the structure of both, if the orientation were presented with the same as that presented for guanine in this encyclopedia. Please just flip it around so the hex and penta sections can be superimposed on the guanine representations. This would more clearly indicate the distinctions as well as the similarities between the molecules.
I moved this here for discussion, as I do not understand how this content derives from the sources:
lead
The wholesale cost is between 0.03 and 0.12 USD per dose.[1] In the United States it is not very expensive at about 0.50 USD per dose.[2][3]
body - Cost subsection
The wholesale cost is between 0.03 and 0.12 USD per dose.[1] In the United States it is not very expensive at less than 25 USD per course of treatment.[3]
References
^ ab"Aciclovir". International Drug Price Indicator Guide. Retrieved 6 September 2015.
If you look at the source "Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition" it gives the cost in the USA as less than 25 USD for a course of treatment.
not comfortable with this, per the note left on the article; the drug retails at 13.5 cents per pill at walmart and target. when we start talking about "price" concretely like this, we really risk losing credibility when there is public information that is very different, and that everyday people actually make transactions about. Talking about things like wholesale price (with limitations of for whom, and when) does make some sense to me. But "price" is problematic. I've amended the US price with "0.13 to xxxx" and added the target price list as a source. that feels spammy to me but I don't know how else to get content that reflects the RW. Jytdog (talk) 02:38, 8 March 2016 (UTC)[reply]
Have adjusted it to 0.22 to 0.50 USD. 400 mg is a single dose (so two tabs). Price is 90 200 mg tabs for 10 USD = 0.22 per 400 mg
thanks that is great. I don't have acess to that pocket guide not even through a university medical library. appears very handy tho! Jytdog (talk) 02:41, 8 March 2016 (UTC)[reply]
I found an interesting article in The Los Angeles Times that speaks to the distinction between Zovirax cream and Zovirax ointment. It also speaks to Canadian vs. American pricing. Something to consider for inclusion. This is from Newspapers.com and comes in two parts:
I've been trying to find a good reference for the diagnosis of neurotoxicity of aciclovir (particularly in people with renal impairment). Today I heard of the utility of the determination of 9-carboxymethoxymethylguanine in blood and CSF as a marker, and the fact that this seems not be removed by haemofiltration. JFW | T@lk08:26, 29 May 2019 (UTC)[reply]
:-) I re-inserted the ref, roughly an hour after your removal! By the way, is there any new literature on how exactly 9CMMG leads to the disorders? I guess it is not discovered yet but my last corpus-review in the area, was quite back. ∯WBGconverse10:34, 14 June 2019 (UTC)[reply]
level-5 vital article is rated B-class on Wikipedia's content assessment scale.
