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Dudes. How about writing this over in English?--149.152.34.80 (talk) 21:55, 17 May 2009 (UTC)[reply]
Yes, this was written by an idiot. This is wikipedia not your biology textbook. Also, consider the idea of complexity ramp. What idiot hits the reader with this first sentence:
"In immunology, antigens (Ag) are structures (aka substances) specifically bound by antibodies (Ab) or a cell surface version of Ab ~ B cell antigen receptor (BCR)."
--93.73.58.129 (talk) 20:53, 20 April 2019 (UTC)[reply]
This is like vandalism. You would have been better not making any addition. Is this autism?
-93.73.58.129 (talk) 20:55, 20 April 2019 (UTC)[reply]
1st para is incomprehensible to those who don't already know what an antigen is. And then what would be the point of the Wikipedia? Showing off? --189.130.3.218 (talk) 04:28, 26 July 2015 (UTC)[reply]
This paragraph doesn't match what I'm reading in other articles. Is this paragraph implying that polyclonal antibodies cannot attack free floating antigens?
Should this article be reworked? The wording is a bit odd and mostly not correct (although it is very easy to read, especially for the non-scientist). User:Stmoran, 14 May 2005
Source: https://en.wikipedia.org/wiki/Antigen_processing#The_exogenous_pathway Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026165/ All antigens come from outside the body by the most basic definition (foreign substance). There are of course multiple definitions as other users point out here, but classifying exogenous antigens as foreign (outside the body) suggests endogenous antigens are self-antigens (inside the body), which is incorrect. Exogenous versus endogenous antigens refers to where the antigens are located relative to a cell, not the entire body. This has important implications on how antigens are processed and loaded up onto MHC, then displayed to Tc or Th lymphocytes. Endogenous antigens start from within the cytoplasm (infected cells or nucleotide-based vaccines) and are loaded onto MHCI, while exogenous antigens are those engulfed by Antigen Presenting Cells (such as macrophages or activated B cells), they never enter the cytoplasm, and are loaded onto MHC II. At the very least, it should be mentioned there are multiple definitions of endogenous versus exogenous in the fields of biology, but in immunology there is a special and important set of definitions for these two words. This concept is very important for understanding whether Tc or Th cells are activated (which is a difference in life or death for the cell with an antigen). Laird.sheldahl (talk) 16:45, 10 June 2022 (UTC)[reply]
An antigen is ANY BODY that stimulates antibody prouction, from the immune system against it. Source: http://www.nlm.nih.gov/medlineplus/ency/article/002224.htm --Chazz88 22:08, 11 October 2005 (UTC)[reply]
In my immunology course I was given slightly different definitions for antigen and immunogen. According to what I learned, antigens are substances that can bind to components of the immune system, but not necessarily cause an actual immune response. An immunogen, however, was defined as a substance that can cause an acquired immune response. The definition for antigen given in this article is different. Any thoughts? -Campaigner444 00:46, 4 November 2005 (UTC)[reply]
That's what I was taught by my prof. too. 75.155.134.185 (talk) 21:44, 26 December 2008 (UTC)[reply]
If they're two separate entities with two different sets of attributes, they should be split. Encyclopedic articles aren't pan-topical.--Cesium_133 (talk) 13:17, 29 April 2009 (UTC)[reply]
It is widely recognized by medical professionals that menstrual fluid contains a bacteria associated with Daujeszky's Disease, a antigen in men that has gone unrecognized for many years. Known side effects include stomach cramps, nausea, diarrhea, and severe inflammation of the urethra. If not treated properly it could result in urinary infection lasting for up to several days.
A finding of Dr. Joan Hiniesne, a professor at Cambridge University, suggests that Daujeszky’s Disease occurs primarily in young sexual active men. A case study in Austin, Texas followed a man, “Dave” (hiding actual name under privacy clause), for several months after having intercourse during the menstrual cycle of a female participant. The study concluded that symptoms often arise fairly suddenly and last for any number of days; perhaps even weeks depending on severity. “This is a very common effect of intercourse during the menstrual cycle” Reported by Casey Snyder of the Washington Medical Journal in an article entitled: Presumptions of Safety during Sex.
information by User:Kjsogjs (contributions) over four edits 7 February 2007
removal --ZayZayEM 01:19, 7 February 2007 (UTC)[reply]
that is the result of vandalism, right? 0.0 --TiagoTiago (talk) 10:14, 20 November 2007 (UTC)[reply]
The basic definition given on this page (i.e. antigen = immunogen) is wrong. There needs to be two separate articles. One is a sub-class of the other.
Immunogens refer to antigens that are able to stimulate a specific adaptive immune response when introduced into the body. Not all antigens are immunogens. To be immunogenic, antigens must fulfil certain criteria, such as i/ being large enough, ii/ chemically complex and iii/ in most of the cases foreign.
For instance a hapten is an antigenic substance but not immunogenic. XApple (talk) 17:24, 8 June 2008 (UTC)[reply]
This article should discuss the chemical composition of antigens. As well as their structure, capabilities... —Preceding unsigned comment added by 76.106.58.112 (talk) 01:08, 14 May 2009 (UTC)[reply]
What are practical examples of antigens ? Are they vaccines and antitoxins ? Include to article
Why is the article entitled "Antibody generator"? "Antigen" is far more commonly used in the UK. Also, the text of the article uses the term "antigen", not "antibody generator". Axl ¤ [Talk] 10:44, 29 August 2009 (UTC)[reply]
I removed my previous comments on the relationship between the concepts of "immunogen" and "antigen" since my case contradicts the authority of accepted text books on the subject.
In reviewing "Kuby Immunology" I read:
"Antigens are defined specifically as molecules that interact with the immunoglobulin receptor of B-cells (or with the T-cell receptor when complexed with MHC)."
This is clearly a bit different from the concept of "antibody generator" from which the term antigen derives (see Antigen#Origin_of_the_term_antigen).
Also, even the Kuby definitions has its caveats, since "molecules that interact with the immunoglobulin receptor" would include molecules that can attach to antibodies (immunoglobulins) in their own right. For example, a molecule like protein A "attacks" antibodies by binding to invariable regions of immunoglobulin molecules without acting as an antigen. Of course, protein A can also act as an immunogenic-antigen since it is a "non-self" molecule that would induce the production of anti-protein A antibodies.
So it seems that it is not easy to arrive at a precise, logical and historically consistent definition of "antigen".
Any thoughts on current state of the article?
Here is the current lead paragraph of the article:
And here is the definition from the MedlinePlus website of the National Institutes of Health:
Now which one do you think most readers would understand?
This page needs to be seriously reworked by an expert who knows how to write for people who aren't themselves experts already. -- Mwalcoff (talk) 02:02, 10 March 2010 (UTC)[reply]
ANON READER Someone please fix this article. It is amateur at best and half the definitions are incorrect. An antigen isn't defined by presence of a foreign macromolecule alone, it also includes self. — Preceding unsigned comment added by 157.182.148.39 (talk) 16:44, 7 December 2011 (UTC)[reply]
What is the topic sentence even trying to say? To a non-technical reader, this means nothing at all: "In immunology, TCR or BCR or its secreted form antibody." Can someone please either clarify this or remove it? Daemon328 (talk) 16:37, 29 January 2016 (UTC)[reply]
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In the light of the coronavirus situation I came here to find out; I'm none the wiser. The article is essentially just techno-babble. Could someone who knows the subject modify the lead so that the layman can understand it? Incidentally, I note the first comment on the Talk page, from 2009, makes a similar request. Arcturus (talk) 12:25, 5 April 2020 (UTC)[reply]
Antigen source. I'm assuming that antigens are trigger proteins that are originally found on viruses and vaccines that are introduced from weakened or dead viruses. These are what antibodies are formed from and reside in the body for future infection reaction? Antigens are not created by the body in response to infection being detected? 2601:187:8080:2310:E08E:5137:1C7A:4BBD (talk) 15:26, 1 January 2022 (UTC)[reply]