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Is this article in the public domain? http://www.addl.purdue.edu/newsletters/1997/spring/bromoethalin.shtml Seems to be a good source of info.75.20.207.153 13:31, 7 November 2006 (UTC)[reply]
It would be nice to know. I think that all chemicals should have their synthesis listed. No matter what it is.--Douglas Bradford Oliver 16:57, 28 December 2006 (UTC)[reply]
I believe this chemical works just like 2,4 dinitrophenol, There are many similarity's in structure between the two mitochondrial toxins. See: http://scienceblogs.com/moleculeoftheday/2006/11/06/24dinitrophenol-dont-mess-with/
"Since a hydrophobic membrane separates the high- and low-proton concentration sides of the gradient, the protons cannot cross this membrane very easily (except when being used to generate some ATP). The lipophilic 2,4-DNP, however, will move through the membrane with facility, shuttling protons down the gradient along the way. It does this for free, too – you don’t get any ATP out of the deal! The proton gradient is converted into heat. Effectively having a severed fuel line, a DNP-dosed subject will burn many calories (and run a fever) just to keep up with basic ATP requirements."
24.186.0.101 (talk) 00:55, 4 June 2013 (UTC)[reply]
This was my first thought too, in which case the article shouldn't say that the compound decreases ATP synthesis. As I understand it, an organism thus poisoned will still make the ATP they need, they just waste a lot of energy and generate a lot of heat in the process, eventually causing fatal heatstroke. It seems ATP is so important that our bodies will literally either make it or die trying. 91.135.7.188 (talk) 22:24, 28 March 2015 (UTC)[reply]
Bromethalin is a pro-drug that is demethylated via the action of a cytochrome P450 in the liver. The product of demethylation (a diphenylamine with two benzene rings that have lots of electron withdrawing groups) is a very active uncoupler of oxidative phosphorylation as it is hydrophobic and has a relatively low pKa (cf. 2,4-dinitrophenol, pKa 4.09, which is a well-known oxidative phosphorylation uncoupler). This means the anion can disrupt the electrochemical gradient in the inner mitochondrial membrane and dissociate ATP from electron transport. The mechanism of action part of the article needs re-writing. Philip Jewess — Preceding unsigned comment added by 62.133.13.170 (talk) 15:12, 27 January 2020 (UTC)[reply]
The following Wikimedia Commons file used on this page has been nominated for speedy deletion:
You can see the reason for deletion at the file description page linked above. —Community Tech bot (talk) 18:51, 17 September 2018 (UTC)[reply]
I would like some additional (scientifically tested) information on its toxicity to (predators of mice in particular.) House cats, domestic dogs, owls or other birds of prey, and foxes especially. --2600:6C48:7006:200:B056:6066:1296:EF0B (talk) 00:37, 20 November 2018 (UTC)[reply]
