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Talk:Cystic fibrosis

This is the talk page for discussing improvements to the Cystic fibrosis article. This is not a forum for general discussion of the article's subject.

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	This article appeared on Wikipedia's Main Page as Today's featured article on July 6, 2006.
Article milestones Date Process Result June 1, 2006 Peer review Reviewed June 10, 2006 Featured article candidate Promoted January 5, 2010 Featured article review Demoted April 30, 2010 Good article nominee Not listed Current status: Former featured article

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 19 August 2019 and 13 December 2019. Further details are available on the course page. Student editor(s): Katjenkins0520. Peer reviewers: Micheladitmore.

Above undated message substituted from Template:Dashboard.wikiedu.org assignmentbyPrimeBOT (talk) 18:55, 16 January 2022 (UTC)[reply]

Guido Fanconi described a connection between celiac disease, cystic fibrosis of the pancreas, and bronchiectasis, that makes the first to describe the cystic fibrosis in relation to other conditions, not Dorothy Hansine Andersen. The title of the picture, stats that she is first to describe, the title should be fixed. She is the first to describe the condition, Guido Fanconi is

"CF can result from more than a thousand different mutations, and as of 2006 it is not possible to test for each one. Testing analyzes the blood for the most common mutations such as ΔF508"

Presumably there has been some progress over the last ten years. David Cary Hart (talk) 15:24, 19 June 2016 (UTC)[reply]

Updated to 2016. Still appears to be true. Doc James (talk · contribs · email) 17:14, 19 June 2016 (UTC)[reply]

doi:10.1016/S0140-6736(16)00576-6 JFW | T@lk 08:37, 2 September 2016 (UTC)[reply]

doi:10.1016/S0140-6736(16)00576-6 JFW | T@lk 22:55, 19 November 2016 (UTC)[reply]

Hahaha, the section above was created when this article was "online first". It's now in print. JFW | T@lk 22:56, 19 November 2016 (UTC)[reply]

Shouldn't we mention furanones ?^[1][2] They can be used to treat cystic fibrosis (described by Michael Givskov of the Technical University of Denmark). See http://www.nature.com/news/2002/020111/full/news020107-12.html KVDP (talk) 12:56, 5 December 2016 (UTC)[reply]

I just watched a program on the treatment on bacteria-resistant lung infections in CS patients using bacteriophages, for example New Patent on Phage Therapy to Overcome Antibiotic Resistance in CF Awarded. I think it might be relevant to add to the section on 'Other treatments for lung disease'. Chalky (talk) 12:25, 9 January 2017 (UTC)[reply]

Would need a review article. Doc James (talk · contribs · email) 12:31, 9 January 2017 (UTC)[reply]

It is problematic that the image at the top of the page is of clubbed fingers. That is something that only some people with CF have. It would make much more sense to have a picture of lungs at the top, since that is a feature of CF that is the most common. Alternatively, an illustration of the genetic defect would work. Could someone please move the picture of clubbed fingers lower on the page and put something more relevant at the top? CanadianJane (talk) 16:08, 3 August 2018 (UTC)[reply]

Not really problematic. It is a classic finding and present in about 80% of people with the condition. Doc James (talk · contribs · email) 12:56, 4 August 2018 (UTC)[reply]

I have reincorporated a source that was initially deleted as primary. It is an editorial that accompanied the publication of a study. It was used for context. I moved the entire section to treatment and am using the editorial for the context not included in the Cochrane review. I hope this passes muster. BiologicalMe (talk) 14:48, 5 September 2018 (UTC)[reply]

This article https://www.bbc.co.uk/news/av/disability-42358852/the-choir-that-can-never-sing-together states that "Any physical contact [with others with CF] poses a serious cross infection risk" and should therefore be avoided. Is this generally accepted? Would this be useful info to add to this article, in the Management section section for example? FrankSier (talk) 22:48, 15 September 2018 (UTC)[reply]

Would someone with more knowledge than I please add a section on this new drug. It is getting lots of press including here: https://www.washingtonpost.com/health/2019/10/31/long-awaited-cystic-fibrosis-drug-could-turn-deadly-disease-into-manageable-condition/ — Preceding unsigned comment added by 128.125.185.134 (talk) 19:32, 31 October 2019 (UTC)[reply]

So, I've been retired for 8 years. In the meantime, I've spent 5 years working as a researcher in this field and this article is dangerously out of date. In that time I've also forgotten all of the policies that I used to be able to type out in my sleep. I'd appreciate any help as I try cleaning up and overhauling this article to reflect the (much more positive!) current state of CF knowledge and treatment. Danger ^{High voltage!} 16:18, 25 September 2021 (UTC)[reply]

Hi@Danger: i was just reading this talk page. Did you have any success? Are there some areas/sections that you want to list here and maybe we can try to gather some secondary sources and tackle anything else. JenOttawa (talk) 21:10, 8 May 2023 (UTC)[reply]

I am not suitably qualified to feel comfortable removing this but it is not clearly based on fact.

'Comorbidities' and Intracellular electrolytes.

Persons with CF show an extraordinary number of "comorbidities" affecting almost every organ in the body. These have in the past been viewed as incidental and not caused directly by the faulty CFTR gene but that should be reconsidered. If Chloride is not being pumped out of cells because of the faulty CFTR channel, then the levels within the cells will be high and will need be balanced by increased cations (Potassium and Calcium in particular). High Calcium in the parathyroid cells may be expected to affect the function of that gland and so too the bones, causing hypoporosis. High intracellular potassium may be expected to affect Adrenal function causing hypokalaemia. Muscle activity may be affected by these electrolyte abnormalities including cardiomyopathy of the heart. Nerve function is affected by electrolytes esp. Potassium. The endocrine cells of the Pancreas that produce Insulin, in the Islets of Lanaghans, may be affected too. Our personal experience is that the response to treatment of Hypoglycemia is better if glucose is given in an electrolyte drink.

More research is needed into intracellular electrolytes in pwCF. We may well find the CFTR gene affects EVERY cell in the body not just those producing mucous. 118.93.131.49 (talk) 15:41, 31 May 2023 (UTC)[reply]

From https://x.com/sarahzhang/status/1765798523512012861 and https://www.drugs.com/trikafta.html it seems like this article statement that there is no cure isn't really true anymore? Should this be updated?

Boxed (talk) 13:38, 21 May 2024 (UTC)[reply]