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I think it should be made clear that the information contained here applies to humans, and may be inaccurate for many other species. Not to nitpick, but food animal reproduction (for example) is a pretty big industry, and I can imagine someone interested in animal pregnancy searching for "implanation" on Wikipedia.
The name has now been changed, but that leaves the issue of where implantation in other species should be described. Given that it's mostly the same, it seems it would be a rather trivial content fork to create such an article. Anaxial (talk) 10:01, 27 May 2012 (UTC)[reply]
Yea this needs somer serious re-writing for it to be accurate. The first bit in particular is complete crap. For example in marsupials, implantation (if it can still be called that) happens on the last day or so of pregnancy. — Preceding unsigned comment added by 130.132.173.239 (talk) 20:25, 22 June 2016 (UTC)[reply]
it is stated that if something is wrong implantion won't occur and there will be miscarriage. well, how can there be miscarriage if there was no implantation? —Preceding unsigned comment added by 109.199.0.114 (talk) 20:18, 5 April 2010 (UTC)[reply]
The following discussion is an archived discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. No further edits should be made to this section.
The above discussion is preserved as an archive of a requested move. Please do not modify it. Subsequent comments should be made in a new section on this talk page. No further edits should be made to this section.
I propose that we add additional content to this page, to discuss the evolutionary origin of implantation in humans. I wrote the content below for this section, but it was subsequently removed by expert user Jytdog. It was removed on the grounds that it refers to primary literature (even though it also refers to review articles), and that it includes self citations. If any other users agree that this content is useful, please feel free to add it to the article page.
Evolutionary Origin of implantation
Implantation is a process unique to eutherian (formerly known as placental) mammals. In this group, all species studied have an implantation reaction that involves the apposition of the embryo and maternal tissue, the attachment of the embryo to the uterine surface, and invasion of the embryo into the uterine mucosa. In some species, including ruminants, this invasion is suppressed by the endometrium. [1] However, there is strong evidence that the ancestral implantation process for eutherians was invasive. [2]
To understand the evolutionary origin of this implantation process, researchers have looked to the closest relatives of eutherian mammals, the marsupials. Marsupial pregnancy is short and does not have maternal-fetal interaction until the last few days of gestation. However, on the last few days of pregnancy a placenta forms following the apposition of the trophoblast with the uterine wall. The formation of the placenta results in significant changes to the morphology and gene expression in the uterus.[3] At a transcriptome wide level, there is significant overlap with this period of placenta formation and implantation in eutherian mammals. [4]
The similarities between the opossum attachment reaction and eutherian implantation also include the expression of human markers of uterine receptivity (MUC1, SPP1, and HBEGF), expression of pro-inflammatory cytokines (IL6, TNF, and IL8), and consistent morphological changes to the uterine luminal epithelium. Together these similarities suggest that implantation is a modified form of the maternal fetal attachment reaction that is still present in marsupials today.[5][6][7]
^Samuel, C.A. and Perry, J.S., 1972. The ultrastructure of pig trophoblast transplanted to an ectopic site in the uterine wall. Journal of anatomy, 113(Pt 1), p.139.
^Wildman, D.E., Chen, C., Erez, O., Grossman, L.I., Goodman, M. and Romero, R., 2006. Evolution of the mammalian placenta revealed by phylogenetic analysis. Proceedings of the National Academy of Sciences of the United States of America, 103(9), pp.3203-3208.
^Hansen, V.L., Schilkey, F.D. and Miller, R.D., 2016. Transcriptomic Changes Associated with Pregnancy in a Marsupial, the Gray Short-Tailed Opossum Monodelphis domestica. PloS one, 11(9), p.e0161608.
^Griffith, O.W., Chavan, A.R., Protopapas, S., Maziarz, J., Romero, R. and Wagner, G.P., 2017. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings of the National Academy of Sciences, p.201701129.
^Griffith, O.W., Chavan, A.R., Protopapas, S., Maziarz, J., Romero, R. and Wagner, G.P., 2017. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings of the National Academy of Sciences, p.201701129.
^Mor, G., Aldo, P. and Alvero, A.B., 2017. The unique immunological and microbial aspects of pregnancy. Nature Reviews Immunology, 17(8), pp.469-482.
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
This content is what we call synthesis, building up review-like content in Wikipedia from primary sources. This is not acceptable in Wikipedia. "Synthesis" is a form of original research, and "no original research" is one of the key content policies.
Writing here in Wikipedia is not like writing a review paper - the genre here is "encyclopedia" and the mission here is to summarize accepted knowledge. Our epistemology is that we find "accepted knowledge" in already-published literature.
If the synthetic content above is already published somewhere else, please cite that source. if it not published somewhere else, it doesn't belong in Wikipedia - it is your own synthesis. I acknowledge that this may seem preposterous to you. Many working scientists have a hard time getting grounded on what we do here and how we do it. Some find it repulsive even. Jytdog (talk) 18:12, 15 August 2017 (UTC)[reply]
The content is not original, which is why I included the citations. This includes citations to review articles, I apologise for also referencing primary literature. I have since deleted the citations to primary literature and replaced them with citations to the publication in which they are reviewed. However, I think this resource is weaker for it. OliGriffith (talk) 19:51, 15 August 2017 (UTC)[reply]
Implantation is a process unique to eutherian (formerly known as placental) mammals. In this group, all species studied have an implantation reaction that involves the apposition of the embryo and maternal tissue, the attachment of the embryo to the uterine surface, and invasion of the embryo into the uterine mucosa. In some species, including ruminants, this invasion is suppressed by the endometrium. [1] However, there is strong evidence that the ancestral implantation process for eutherians was invasive. [2]
To understand the evolutionary origin of this implantation process, researchers have looked to the closest relatives of eutherian mammals, the marsupials. Marsupial pregnancy is short and does not have maternal-fetal interaction until the last few days of gestation. However, on the last few days of pregnancy a placenta forms following the apposition of the trophoblast with the uterine wall. The formation of the placenta results in significant changes to the morphology and gene expression in the uterus.[3] At a transcriptome wide level, there is significant overlap with this period of placenta formation and implantation in eutherian mammals. [4]
The similarities between the opossum attachment reaction and eutherian implantation also include the expression of human markers of uterine receptivity (MUC1, SPP1, and HBEGF), expression of pro-inflammatory cytokines (IL6, TNF, and IL8), and consistent morphological changes to the uterine luminal epithelium. Together these similarities suggest that implantation is a modified form of the maternal fetal attachment reaction that is still present in marsupials today.[5][6]
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
^Mor, G., Aldo, P. and Alvero, A.B., 2017. The unique immunological and microbial aspects of pregnancy. Nature Reviews Immunology, 17(8), pp.469-482.
^Chavan, A.R., Griffith, O.W., and Wagner, G.P., 2017. The Inflammation Paradox in the Evolution of Mammalian Pregnancy: turning a foe into a friend. Current Opinions in Genetics & Development.
1) First, please never change content on a talk page, once somebody else has responded to it. Doing that renders what the other person wrote into nonsense. You can WP:REDACT a comment that someone has responded to, or you can just do as I did here, and post another version.
2) It would be really helpful if you followed the instructions for formatting refs as described in WP:MEDHOW -- there is an automated tool that enables you to format refs very, very quickly, if you start with the pmid or the like. Also instead of repeating citations, we use a markup called "ref name" to cite things multiple times.
The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.
The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.
Is already covered on target page where it is better presented - as a stub it had been redirected there but has been replaced with content copied from target page. Iztwoz (talk) 21:55, 23 April 2023 (UTC)[reply]
Oppose I have also added other information beyond the two sentences taken from the general implantation page. There is much academic work out there done on the topic and there is no reason to merge instead of expanding the article.★Trekker (talk) 22:00, 23 April 2023 (UTC)[reply]
While that may be the more usual course there is no rule that says it has to be done that way. Implantation is an incredibly important subject and there is more than enough material to expand the implantation article as well as the implantation failure article to large sizes.★Trekker (talk) 22:20, 23 April 2023 (UTC)[reply]
I have replied to your comment that you posted on implantation failure page. Also why not follow the normal course of expansion first on target page? And when you reverted my redirect, this redirect has been longstanding since 2011 I simply updated the redirect section. --Iztwoz (talk) 08:59, 24 April 2023 (UTC)[reply]
I don't see any need to do it that way, I enjoy working this way. If a subject is notable I don't have a problem with something starting out as a small article that is built over time.★Trekker (talk) 10:06, 24 April 2023 (UTC)[reply]
Withdraw Withdraw merge proposal since there is nothing to merge. The first definition is incorrect as must be the source. The rest has just been copied from page without attribution. The only new additions are irrelevant see also items - referring to death and loss. Loss is not the same as failure. Needs to stand as a redirect page.--Iztwoz (talk) 06:37, 26 April 2023 (UTC)[reply]
