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I removed the text regarding the finding of rifampicin in Slobodan Milošević's bloodstream, because it is completely irrelevant to this article. It could, conceivably, be useful information for the Slobodan Milošević article but not this one. -Techelf 07:53, 14 March 2006 (UTC)[reply]
doi:10.1371/journal.pmed.1000146 PLOS review. JFW | T@lk 20:17, 15 September 2009 (UTC)[reply]
Please would someone rewrite the last sentence of the section "Pharmacokinetics" ? —Preceding unsigned comment added by Darkman101 (talk • contribs) 02:27, 3 May 2011 (UTC)[reply]
Rifampin is well known inducer of CYP3A4 as well as CYP2C9 in vivo. (CYP2D6 in not considered an inducible enzyme) 146.79.254.10 (talk) 17:59, 3 August 2011 (UTC)AW[reply]
Current source reference incorrectly lists induction of CYP2D6 but provides no further valid citation. As mentioned above, CYP2D6 is not considered inducible, and I am removing CYP2D6 from main article. Mrbippers (talk) 00:23, 8 January 2015 (UTC)[reply]
The article states without citation that pseudomonas is inherently resistant to rifampin. While pseudomonas can develop resistance to rifampin, I cannot find a reference for the idea that it is inherently resistant -- in fact, I actually ended up on this page because I have been reading articles detailing surprisingly good outcomes in pseudomonas aeruginosa induced osteomyelitis obtained by adding rifampin to other antibiotics. I'll eliminate / edit the relevant lines if I don't hear back from anyone here. — Preceding unsigned comment added by 47.16.226.233 (talk) 17:25, 4 August 2016 (UTC)[reply]
Drugs with rifampicin were introduced in 1968 - not in 1971! see https://www.ncbi.nlm.nih.gov/pubmed/6635432 an various other sources. — Preceding unsigned comment added by 94.228.152.68 (talk) 09:28, 2 January 2017 (UTC)[reply]
Done, thanks! Jytdog (talk) 09:43, 2 January 2017 (UTC)[reply]This may sound somewhat trivial but it can lead to an Addisonian Crisis in those with Addison's Disease which is life threatening. I would like to suggest that the steroid hormone Cortisol be specifically mentioned in the article wherever may be appropriate (I see mention of increased metabolic clearance of medications but not hormones) as it may help save lives. Perhaps include mention under adverse effects?
See below for my personal experience.
https://www.ncbi.nlm.nih.gov/pubmed/2209230
We conclude that the increase of metabolism of cortisol after simultaneous taking of rifampicin may induce adrenal
crisis in Addison's disease.
https://www.ncbi.nlm.nih.gov/pubmed/471734
This enzyme induction results in a need to increase the dose of hydrocortisone substitution therapy in patients with
Addison's disease treated with rifampicin.
https://www.jstage.jst.go.jp/article/kekkaku1923/61/2/61_2_71/_article
The maximum plasma concentration of cortisol (hydrocortisone) in group (hydrocortisone+RFP) was as low as 40% of
that in control patients (group hydrocortisone).
https://www.ncbi.nlm.nih.gov/pubmed/4140269
Personal experience - It sent me, a well controlled Addison's patient, to the ER where I received an emergency shot of Cortef (Cortisol) and it was discovered that my blood cortisol level was dangerously low.
My pharmacist, at a national retailer, was unaware of this action as were his coworkers, and their computerized system made no mention of a Rifampicin/Cortisol interaction. Lets help spread the info! — Preceding unsigned comment added by 2600:1700:3610:850:A08A:2A6A:16CB:674 (talk) 03:18, 4 December 2017 (UTC)[reply]
Rifampicin in made by the soil bacterium Amycolatopsis rifamycinica - The bacterium makes rifamycin, which is synthetically converted to rifampicin. 64.26.99.248 (talk) 21:52, 22 December 2018 (UTC)[reply]
