Contents

3-oxoacid CoA-transferase

Enzyme family

3-oxoacid CoA-transferase (SCOT)
Pig succinyl-CoA 3-oxoacid transferase PDB: 3K6M​
Identifiers
EC no.	2.8.3.5
CAS no.	9027-43-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Inenzymology, a 3-oxoacid CoA-transferase (EC 2.8.3.5) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + a 3-oxo acid ${\displaystyle \rightleftharpoons }$ succinate + a 3-oxoacyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include succinyl-CoA-3-ketoacid-CoA transferase, 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies,^[1] valine, leucine and isoleucine degradation, and butanoate metabolism.

This protein may use the morpheein model of allosteric regulation.^[2]

Structural studies[edit]

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1M3E, 1O9L, 1OOY, 1OOZ, 1OPE, 2NRB, and 2NRC.

References[edit]

• Hersh LB, Jencks WP (1967). "Coenzyme A transferase. Kinetics and exchange reactions". J. Biol. Chem. 242: 3468–3480. doi:10.1016/S0021-9258(18)95886-2.
• Lynen F, Ochoa S (1953). "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta. 12 (1–2): 299–314. doi:10.1016/0006-3002(53)90149-8. PMID 13115439. S2CID 1546557.
• Menon GK, Stern JR (1960). "Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A". J. Biol. Chem. 235 (12): 3393–3398. doi:10.1016/S0021-9258(18)64478-3. PMID 13769479.
• Stern JR, Coon MJ, del Campillo A, Schneider MC (1956). "Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase". J. Biol. Chem. 221 (1): 15–31. doi:10.1016/S0021-9258(18)65225-1. PMID 13345795.