Contents

List of EC numbers (EC 6)

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)[edit]

• EC 6.1.1.1: tyrosine—tRNA ligase
• EC 6.1.1.2: tryptophan—tRNA ligase
• EC 6.1.1.3: threonine—tRNA ligase
• EC 6.1.1.4: leucine—tRNA ligase
• EC 6.1.1.5: isoleucine—tRNA ligase
• EC 6.1.1.6: lysine—tRNA ligase
• EC 6.1.1.7: alanine—tRNA ligase
• EC 6.1.1.8: Deleted
• EC 6.1.1.9: valine—tRNA ligase
• EC 6.1.1.10: methionine—tRNA ligase
• EC 6.1.1.11: serine—tRNA ligase
• EC 6.1.1.12: aspartate—tRNA ligase
• EC 6.1.1.13: D-alanine—poly(phosphoribitol) ligase
• EC 6.1.1.14: glycine—tRNA ligase
• EC 6.1.1.15: proline—tRNA ligase
• EC 6.1.1.16: cysteine—tRNA ligase
• EC 6.1.1.17: glutamate—tRNA ligase
• EC 6.1.1.18: glutamine—tRNA ligase
• EC 6.1.1.19: arginine—tRNA ligase
• EC 6.1.1.20: phenylalanine—tRNA ligase
• EC 6.1.1.21: histidine—tRNA ligase
• EC 6.1.1.22: asparagine—tRNA ligase
• EC 6.1.1.23: aspartate—tRNA^Asn ligase
• EC 6.1.1.24: glutamate—tRNA^Gln ligase
• EC 6.1.1.25: The tRNA^Pyl is now known only to be charged with pyrrolysine (cf. EC 6.1.1.26)
• EC 6.1.1.26: pyrrolysine—tRNA^Pyl ligase
• EC 6.1.1.27: O-phospho-L-serine—tRNA ligase
• EC 6.1.1.28: proline/cysteine—tRNA ligase. Later published work having demonstrated that this was not a genuine enzyme, EC 6.1.1.28 was withdrawn at the public-review stage before being made official

EC 6.1.2: Acid—alcohol ligases (ester synthases)[edit]

• EC 6.1.2.1: D-alanine—(R)-lactate ligase
• EC 6.1.2.2: nebramycin 5′ synthase *

* No Wikipedia article

EC 6.1.3: Cyclo-ligases[edit]

• EC 6.1.3.1: olefin β-lactone synthetase *

* No Wikipedia article

EC 6.2: Forming Carbon-Sulfur Bonds[edit]

EC 6.2.1: Acid-Thiol Ligases[edit]

• EC 6.2.1.1: acetate—CoA ligase
• EC 6.2.1.2: medium-chain acyl-CoA ligase
• EC 6.2.1.3: long-chain-fatty-acid—CoA ligase
• EC 6.2.1.4: succinate—CoA ligase (GDP-forming)
• EC 6.2.1.5: succinate—CoA ligase (ADP-forming)
• EC 6.2.1.6: glutarate—CoA ligase
• EC 6.2.1.7: cholate—CoA ligase
• EC 6.2.1.8: oxalate—CoA ligase
• EC 6.2.1.9: malate—CoA ligase
• EC 6.2.1.10: carboxylic acid—CoA ligase (GDP-forming)
• EC 6.2.1.11: biotin—CoA ligase
• EC 6.2.1.12: 4-coumarate—CoA ligase
• EC 6.2.1.13: acetate—CoA ligase (ADP-forming)
• EC 6.2.1.14: 6-carboxyhexanoate—CoA ligase
• EC 6.2.1.15: arachidonate—CoA ligase
• EC 6.2.1.16: acetoacetate—CoA ligase
• EC 6.2.1.17: propionate—CoA ligase
• EC 6.2.1.18: citrate—CoA ligase
• EC 6.2.1.19: long-chain-fatty-acid—protein ligase
• EC 6.2.1.20: long-chain-fatty-acid—[acyl-carrier-protein] ligase
• EC 6.2.1.21: Activity covered by EC 6.2.1.30, phenylacetate—CoA ligase
• EC 6.2.1.22: [citrate (pro-3S)-lyase] ligase
• EC 6.2.1.23: dicarboxylate—CoA ligase
• EC 6.2.1.24: phytanate—CoA ligase
• EC 6.2.1.25: benzoate—CoA ligase
• EC 6.2.1.26: o-succinylbenzoate—CoA ligase
• EC 6.2.1.27: 4-hydroxybenzoate—CoA ligase
• EC 6.2.1.28: 3α,7α-dihydroxy-5β-cholestanate—CoA ligase
• EC 6.2.1.29: Deleted, identical to EC 6.2.1.7, cholate—CoA ligase
• EC 6.2.1.30: phenylacetate—CoA ligase
• EC 6.2.1.31: 2-furoate—CoA ligase
• EC 6.2.1.32: anthranilate—CoA ligase
• EC 6.2.1.33: 4-chlorobenzoate—CoA ligase
• EC 6.2.1.34: trans-feruloyl-CoA synthase
• EC 6.2.1.35: acetate—[acyl-carrier protein] ligase
• EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase
• EC 6.2.1.37: 3-hydroxybenzoate—CoA ligase
• EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
• EC 6.2.1.39: [butirosin acyl-carrier protein]—L-glutamate ligase
• EC 6.2.1.40: 4-hydroxybutyrate—CoA ligase (AMP-forming) *
• EC 6.2.1.41: 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase *
• EC 6.2.1.42: 3-oxocholest-4-en-26-oate—CoA ligase *
• EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase *
• EC 6.2.1.44: 3-(methylthio)propionyl—CoA ligase *
• EC 6.2.1.45: E1 ubiquitin-activating enzyme *
• EC 6.2.1.46: L-allo-isoleucine—holo-[CmaA peptidyl-carrier protein] ligase *
• EC 6.2.1.47: medium-chain-fatty-acid—[acyl-carrier-protein] ligase *
• EC 6.2.1.48: carnitine—CoA ligase *
• EC 6.2.1.49: long-chain fatty acid adenylyltransferase FadD28 *
• EC 6.2.1.50: 4-hydroxybenzoate adenylyltransferase FadD22 *
• EC 6.2.1.51: 4-hydroxyphenylalkanoate adenylyltransferase FadD29 *
• EC 6.2.1.52: L-firefly luciferin—CoA ligase *
• EC 6.2.1.53: L-proline—[L-prolyl-carrier protein] ligase *
• EC 6.2.1.54: D-alanine—[D-alanyl-carrier protein] ligase *
• EC 6.2.1.55: E1 SAMP-activating enzyme *
• EC 6.2.1.56: 4-hydroxybutyrate—CoA ligase (ADP-forming) *
• EC 6.2.1.57: long-chain fatty acid adenylase/transferase FadD23 *
• EC 6.2.1.58: isophthalate—CoA ligase *
• EC 6.2.1.59: long-chain fatty acid adenylase/transferase FadD26 *
• EC 6.2.1.60: marinolic acid—CoA ligase *
• EC 6.2.1.61: salicylate—[aryl-carrier protein] ligase *
• EC 6.2.1.62: 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase *
• EC 6.2.1.63: L-arginine—[L-arginyl-carrier protein] ligase *
• EC 6.2.1.64: E1 NEDD8-activating enzyme *
• EC 6.2.1.65: salicylate—CoA ligase *
• EC 6.2.1.66: glyine—[glycyl-carrier protein] ligase *
• EC 6.2.1.67: L-alanine—[L-alanyl-carrier protein] ligase *
• EC 6.2.1.68: L-glutamate—[L-glutamyl-carrier protein] ligase *
• EC 6.2.1.69: L-cysteine—[L-cysteinyl-carrier protein] ligase *
• EC 6.2.1.70: L-threonine—[L-threonyl-carrier protein] ligase *
• EC 6.2.1.71: 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase *
• EC 6.2.1.72: L-serine—[L-seryl-carrier protein] ligase *
• EC 6.2.1.73: L-tryptophan—[L-tryptophyl-carrier protein] ligase *
• EC 6.2.1.74: 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase *

+ EC 6.2.1.75: indoleacetate—CoA ligase

* No Wikipedia article

EC 6.2.2: Amide—thiol ligases[edit]

• EC 6.2.2.1: thioglycine synthase *
• EC 6.2.2.2: oxazoline synthase *
• EC 6.2.2.3: thiazoline synthase *

* No Wikipedia article

EC 6.3: Forming Carbon-Nitrogen Bonds[edit]

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)[edit]

• EC 6.3.1.1: aspartate—ammonia ligase
• EC 6.3.1.2: glutamine synthetase
• EC 6.3.1.3: Now EC 6.3.4.13, phosphoribosylamine—glycine ligase
• EC 6.3.1.4: aspartate—ammonia ligase (ADP-forming)
• EC 6.3.1.5: NAD⁺ synthase
• EC 6.3.1.6: glutamate—ethylamine ligase
• EC 6.3.1.7: 4-methyleneglutamate—ammonia ligase
• EC 6.3.1.8: glutathionylspermidine synthase
• EC 6.3.1.9: trypanothione synthase
• EC 6.3.1.10: adenosylcobinamide-phosphate synthase
• EC 6.3.1.11: glutamate—putrescine ligase
• EC 6.3.1.12: D-aspartate ligase
• EC 6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase
• EC 6.3.1.14: diphthine—ammonia ligase
• EC 6.3.1.15: 8-demethylnovobiocic acid synthase *
• EC 6.3.1.16: The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See EC 6.3.3.6, carbapenam-3-carboxylate synthase
• EC 6.3.1.17: β-citrylglutamate synthase *
• EC 6.3.1.18: γ-glutamylanilide synthase *
• EC 6.3.1.19: prokaryotic ubiquitin-like protein ligase *
• EC 6.3.1.20: lipoate—protein ligase *
• EC 6.3.1.21: phosphoribosylglycinamide formyltransferase 2 *

* No Wikipedia article

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)[edit]

• EC 6.3.2.1: pantoate—β-alanine ligase (AMP-forming)
• EC 6.3.2.2: glutamate—cysteine ligase
• EC 6.3.2.3: glutathione synthase
• EC 6.3.2.4: D-alanine—D-alanine ligase
• EC 6.3.2.5: phosphopantothenate—cysteine ligase (CTP)
• EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
• EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
• EC 6.3.2.8: UDP-N-acetylmuramate—L-alanine ligase
• EC 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
• EC 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
• EC 6.3.2.11: carnosine synthase
• EC 6.3.2.12: dihydrofolate synthase
• EC 6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
• EC 6.3.2.14: enterobactin synthase
• EC 6.3.2.15: Deleted, The activity observed is due to EC 6.3.2.10, UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
• EC 6.3.2.16: D-alanine—alanyl-poly(glycerolphosphate) ligase
• EC 6.3.2.17: tetrahydrofolate synthase
• EC 6.3.2.18: γ-glutamylhistamine synthase
• EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 2.3.2.23 (E2 ubiquitin-conjugating enzyme) and EC 2.3.2.27 (RING-type E3 ubiquitin transferase)
• EC 6.3.2.20: indoleacetate—lysine synthetase
• EC 6.3.2.21: The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 [ubiquitin transferase RING E3 (calmodulin-selective)]
• EC 6.3.2.22: Now EC 6.3.1.14, diphthine—ammonia ligase.
• EC 6.3.2.23: homoglutathione synthase
• EC 6.3.2.24: tyrosine—arginine ligase
• EC 6.3.2.25: tubulin—tyrosine ligase
• EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
• EC 6.3.2.27: The activity is covered by two independent enzymes, EC 6.3.2.38 N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase
• EC 6.3.2.28: Now EC 6.3.2.49, L-alanine-L-anticapsin ligase
• EC 6.3.2.29: cyanophycin synthase (L-aspartate-adding)
• EC 6.3.2.30: cyanophycin synthase (L-arginine-adding)
• EC 6.3.2.31: coenzyme F₄₂₀-0:L-glutamate ligase
• EC 6.3.2.32: coenzyme γ-F₄₂₀-2:α-L-glutamate ligase
• EC 6.3.2.33: tetrahydrosarcinapterin synthase
• EC 6.3.2.34: coenzyme F₄₂₀-0:L-glutamate ligase
• EC 6.3.2.35: D-alanine—D-serine ligase
• EC 6.3.2.36: 4-phosphopantoate—β-alanine ligase
• EC 6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
• EC 6.3.2.38: N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase
• EC 6.3.2.39: aerobactin synthase
• EC 6.3.2.40: cyclopeptine synthase *
• EC 6.3.2.41: N-acetylaspartylglutamate synthase *
• EC 6.3.2.42: N-acetylaspartylglutamylglutamate synthase *
• EC 6.3.2.43: [amino-group carrier protein]—L-2-aminoadipate ligase *
• EC 6.3.2.44: pantoate—β-alanine ligase (ADP-forming) *
• EC 6.3.2.45: UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase *
• EC 6.3.2.46: fumarate—(S)-2,3-diaminopropanoate ligase *
• EC 6.3.2.47: dapdiamide synthase *
• EC 6.3.2.48: L-arginine-specific L-amino acid ligase *
• EC 6.3.2.49: L-alanine—L-anticapsin ligase *
• EC 6.3.2.50: tenuazonic acid synthetase *
• EC 6.3.2.51: phosphopantothenate—cysteine ligase (ATP) *
• EC 6.3.2.52: jasmonoyl—L-amino acid ligase *
• EC 6.3.2.53: UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase *
• EC 6.3.2.54: L-2,3-diaminopropanoate—citrate ligase *
• EC 6.3.2.55: 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase *
• EC 6.3.2.56: staphyloferrin B synthase *
• EC 6.3.2.57: staphyloferrin A synthase *
• EC 6.3.2.58: D-ornithine—citrate ligase *
• EC 6.3.2.59: 3-methyl-D-ornithine—L-lysine ligase *
• EC 6.3.2.60: glutamate—[amino group carrier protein] ligase *
• EC 6.3.2.61: tubulin-glutamate ligase *
• EC 6.3.2.62: β-tubulin-glutamate ligase *

* No Wikipedia article

EC 6.3.3: Cyclo-Ligases[edit]

• EC 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase
• EC 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
• EC 6.3.3.3: dethiobiotin synthase
• EC 6.3.3.4: (carboxyethyl)arginine β-lactam-synthase
• EC 6.3.3.5: O-ureido-D-serine cyclo-ligase *
• EC 6.3.3.6: carbapenam-3-carboxylate synthase *
• EC 6.3.3.7: Ni-sirohydrochlorin a,c-diamide reductive cyclase *

* No Wikipedia article

EC 6.3.4: Other Carbon-Nitrogen Ligases[edit]

• EC 6.3.4.1: Now included in EC 6.3.5.2, GMP synthase (glutamine-hydrolysing)
• EC 6.3.4.2: CTP synthase (glutamine hydrolysing)
• EC 6.3.4.3: formate—tetrahydrofolate ligase
• EC 6.3.4.4: adenylosuccinate synthase
• EC 6.3.4.5: argininosuccinate synthase
• EC 6.3.4.6: urea carboxylase
• EC 6.3.4.7: ribose-5-phosphate—ammonia ligase
• EC 6.3.4.8: imidazoleacetate—phosphoribosyldiphosphate ligase
• EC 6.3.4.9: biotin—[methylmalonyl-CoA-carboxytransferase] ligase
• EC 6.3.4.10: biotin—[methylmalonyl-CoA-carboxytransferase] ligase
• EC 6.3.4.11: biotin—[methylcrotonoyl-CoA-carboxylase] ligase
• EC 6.3.4.12: glutamate—methylamine ligase
• EC 6.3.4.13: phosphoribosylamine—glycine ligase
• EC 6.3.4.14: biotin carboxylase
• EC 6.3.4.15: biotin—[biotin carboxyl-carrier protein] ligase
• EC 6.3.4.16: carbamoyl-phosphate synthase (ammonia)
• EC 6.3.4.17: formate—dihydrofolate ligase
• EC 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase
• EC 6.3.4.19: tRNA^Ile-lysidine synthase
• EC 6.3.4.20: 7-cyano-7-deazaguanine synthase
• EC 6.3.4.21: nicotinate phosphoribosyltransferase
• EC 6.3.4.22: tRNA^Ile2-agmatinylcytidine synthase *
• EC 6.3.4.23: formate—phosphoribosylaminoimidazolecarboxamide ligase *
• EC 6.3.4.24: tyramine—L-glutamate ligase *
• EC 6.3.4.25: 2-amino-2′-deoxyadenylo-succinate synthase *

* No Wikipedia article

EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N-donor[edit]

• EC 6.3.5.1: NAD⁺ synthase (glutamine-hydrolysing)
• EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
• EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
• EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
• EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
• EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
• EC 6.3.5.8: Now EC 2.6.1.85, aminodeoxychorismate synthase. As ATP is not hydrolysed during the reaction, the classification of the enzyme as a ligase was incorrect
• EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
• EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)
• EC 6.3.5.11: cobyrinate a,c-diamide synthase
• EC 6.3.5.12: Ni-sirohydrochlorin a,c-diamide synthase *
• EC 6.3.5.13: lipid II isoglutaminyl synthase (glutamine-hydrolysing) *

* No Wikipedia article

EC 6.4: Forming Carbon-Carbon Bonds[edit]

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)[edit]

• EC 6.4.1.1: pyruvate carboxylase
• EC 6.4.1.2: acetyl-CoA carboxylase
• EC 6.4.1.3: propionyl-CoA carboxylase
• EC 6.4.1.4: methylcrotonoyl-CoA carboxylase
• EC 6.4.1.5: geranoyl-CoA carboxylase
• EC 6.4.1.6: acetone carboxylase
• EC 6.4.1.7: 2-oxoglutarate carboxylase
• EC 6.4.1.8: acetophenone carboxylase
• EC 6.4.1.9: coenzyme F₄₃₀ synthetase *

*No Wikipedia article

EC 6.5: Forming Phosphoric Ester Bonds[edit]

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)[edit]

• EC 6.5.1.1: DNA ligase (ATP)
• EC 6.5.1.2: DNA ligase (NAD⁺)
• EC 6.5.1.3: RNA ligase (ATP)
• EC 6.5.1.4: RNA 3′-terminal-phosphate cyclase (ATP)
• EC 6.5.1.5: RNA 3′-terminal-phosphate cyclase (GTP) *
• EC 6.5.1.6: DNA ligase (ATP or NAD⁺) *
• EC 6.5.1.7: DNA ligase (ATP, ADP or GTP) *
• EC 6.5.1.8: 3′-phosphate/5′-hydroxy nucleic acid ligase *
• EC 6.5.1.9: cyclic 2,3-diphosphoglycerate synthase *

* No Wikipedia article

EC 6.6: Forming Nitrogen-Metal Bonds[edit]

EC 6.6.1: Forming Coordination Complexes[edit]

• EC 6.6.1.1: magnesium chelatase
• EC 6.6.1.2: cobaltochelatase

EC 6.7: Forming nitrogen-nitrogen bonds[edit]

EC 6.7.1: Forming diazo bonds[edit]

• EC 6.7.1.1: 3-amino-2-hydroxy-4-methoxybenzoate *

* No Wikipedia article

References[edit]