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(Top) 1 EC 3.1: Acting on Ester Bonds 1.1 EC 3.1.1: Carboxylic Ester Hydrolases 1.2 EC 3.1.2: Thioester Hydrolases 1.3 EC 3.1.3: Phosphoric Monoester Hydrolases 1.4 EC 3.1.4: Phosphoric Diester Hydrolases 1.5 EC 3.1.5: Triphosphoric Monoester Hydrolases 1.6 EC 3.1.6: Sulfuric Ester Hydrolases 1.7 EC 3.1.7: Diphosphoric Monoester Hydrolases 1.8 EC 3.1.8: Phosphoric Triester Hydrolases 1.9 EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters 1.10 EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters 1.11 EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters 1.12 EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters 1.13 EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters 1.14 EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters 1.15 EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters 1.16 EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5 1.17 EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases 1.18 EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters 1.19 EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters 1.20 EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters 1.21 EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters 2 EC 3.2: Glycosylases 2.1 EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds 2.2 EC 3.2.2: Hydrolysing N-Glycosyl Compounds 2.3 EC 3.2.3: Hydrolysing S-Glycosyl Compounds 3 EC 3.3: Acting on Ether Bonds 3.1 EC 3.3.1: Thioether and trialkylsulfonium hydrolases 3.2 EC 3.3.2: Ether Hydrolases 4 EC 3.4: Acting on peptide bonds – Peptidase 4.1 EC 3.4.1 α-amino acyl peptide hydrolases (discontinued) 4.2 EC 3.4.2 Peptidyl amino acid hydrolases (discontinued) 4.3 EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass) 4.4 EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued) 4.5 EC 3.4.11 Aminopeptidases 4.6 EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass) 4.7 EC 3.4.13 Dipeptidases 4.8 EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases 4.9 EC 3.4.15 Peptidyl dipeptidases 4.10 EC 3.4.16 Serine type carboxypeptidases 4.11 EC 3.4.17 Metallocarboxypeptidases 4.12 EC 3.4.18 Cysteine type carboxypeptidases 4.13 EC 3.4.19 Omega peptidases 4.14 EC 3.4.21: Serine proteases 4.15 EC 3.4.22 Cysteine proteases 4.16 EC 3.4.23 Aspartic endopeptidases 4.17 EC 3.4.24: Metallopeptidases 4.18 EC 3.4.25 Threonine endopeptidases 5 EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds 5.1 3.5.1: In linear amides 5.2 3.5.2: In cyclic amides 5.3 3.5.3: In linear amidines 5.4 3.5.4: In cyclic amidines 5.5 3.5.5: In nitriles 5.6 3.5.99: In other compounds 6 EC 3.6: Acting on acid anhydrides 6.1 3.6.1: In phosphorus-containing anhydrides 6.2 3.6.2: In sulfonyl-containing anhydrides 6.3 3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances 6.4 3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement 6.5 3.6.5: Acting on GTP to facilitate cellular and subcellular movement 7 EC 3.7: Acting on carbon-carbon bonds 7.1 EC 3.7.1: In ketonic substances 8 EC 3.8: Acting on halide bonds 8.1 EC 3.8.1: Acting on halide bonds 8.2 3.8.2: In phosphorus-halide compounds (deleted sub-subclass) 9 EC 3.9: act on phosphorus-nitrogen bonds 9.1 EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date) 10 EC 3.10: Acting on sulfur-nitrogen bonds 10.1 EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date) 11 EC 3.11: Acting on carbon-phosphorus bonds 11.1 EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date) 12 EC 3.12: Acting on sulfur-sulfur bonds 12.1 EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date) 13 EC 3.13: Acting on carbon-sulfur bonds 13.1 EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date) 14 References

List of EC numbers (EC 3)

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This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.^[1] The database is developed and maintained by Andrew McDonald.^[2]

EC 3.1: Acting on Ester Bonds[edit]

EC 3.1.1: Carboxylic Ester Hydrolases[edit]

EC 3.1.1.1: carboxylesterase
EC 3.1.1.2: arylesterase
EC 3.1.1.3: triacylglycerol lipase
EC 3.1.1.4: phospholipase A₂
EC 3.1.1.5: lysophospholipase
EC 3.1.1.6: acetylesterase
EC 3.1.1.7: acetylcholinesterase
EC 3.1.1.8: cholinesterase
EC 3.1.1.9: deleted, a side reaction of EC 3.1.1.8 cholinesterase
EC 3.1.1.10: tropinesterase
EC 3.1.1.11: pectinesterase
EC 3.1.1.12: deleted, identical with EC 3.1.1.1 carboxylesterase
EC 3.1.1.13: sterol esterase
EC 3.1.1.14: chlorophyllase
EC 3.1.1.15: L-arabinonolactonase
EC 3.1.1.16: deleted, mixture of EC 5.3.3.4 (muconolactone Δ-isomerase) and EC 3.1.1.24 (3-oxoadipate enol-lactonase)
EC 3.1.1.17: gluconolactonase
EC 3.1.1.18: deleted, Now included with EC 3.1.1.17 gluconolactonase
EC 3.1.1.19: uronolactonase
EC 3.1.1.20: tannase
EC 3.1.1.21: deleted, now known to be catalysed by EC 3.1.1.1, carboxylesterase and EC 3.1.1.3, triacylglycerol lipase.
EC 3.1.1.22: hydroxybutyrate-dimer hydrolase
EC 3.1.1.23: acylglycerol lipase
EC 3.1.1.24: 3-oxoadipate enol-lactonase
EC 3.1.1.25: 1,4-lactonase
EC 3.1.1.26: galactolipase
EC 3.1.1.27: 4-pyridoxolactonase
EC 3.1.1.28: acylcarnitine hydrolase
EC 3.1.1.29: aminoacyl-tRNA hydrolase
EC 3.1.1.30: D-arabinonolactonase
EC 3.1.1.31: 6-phosphogluconolactonase
EC 3.1.1.32: phospholipase A₁
EC 3.1.1.33: 6-acetylglucose deacetylase
EC 3.1.1.34: lipoprotein lipase
EC 3.1.1.35: dihydrocoumarin hydrolase
EC 3.1.1.36: limonin-D-ring-lactonase
EC 3.1.1.37: steroid-lactonase
EC 3.1.1.38: triacetate-lactonase
EC 3.1.1.39: actinomycin lactonase
EC 3.1.1.40: orsellinate-depside hydrolase
EC 3.1.1.41: cephalosporin-C deacetylase
EC 3.1.1.42: chlorogenate hydrolase
EC 3.1.1.43: α-amino-acid esterase
EC 3.1.1.44: 4-methyloxaloacetate esterase
EC 3.1.1.45: carboxymethylenebutenolidase
EC 3.1.1.46: deoxylimonate A-ring-lactonase
EC 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase
EC 3.1.1.48: fusarinine-C ornithinesterase
EC 3.1.1.49: sinapine esterase
EC 3.1.1.50: wax-ester hydrolase
EC 3.1.1.51: phorbol-diester hydrolase
EC 3.1.1.52: phosphatidylinositol deacylase
EC 3.1.1.53: sialate O-acetylesterase
EC 3.1.1.54: acetoxybutynylbithiophene deacetylase
EC 3.1.1.55: acetylsalicylate deacetylase
EC 3.1.1.56: methylumbelliferyl-acetate deacetylase
EC 3.1.1.57: 2-pyrone-4,6-dicarboxylate lactonase
EC 3.1.1.58: N-acetylgalactosaminoglycan deacetylase
EC 3.1.1.59: juvenile-hormone esterase
EC 3.1.1.60: bis(2-ethylhexyl)phthalate esterase
EC 3.1.1.61: protein-glutamate methylesterase
EC 3.1.1.62: Now listed as EC 3.5.1.47, N-acetyldiaminopimelate deacetylase
EC 3.1.1.63: 11-cis-retinyl-palmitate hydrolase
EC 3.1.1.64: retinoid isomerohydrolase
EC 3.1.1.65: L-rhamnono-1,4-lactonase
EC 3.1.1.66: 5-(3,4-diacetoxybut-1-ynyl)-2,2′-bithiophene deacetylase
EC 3.1.1.67: fatty-acyl-ethyl-ester synthase
EC 3.1.1.68: xylono-1,4-lactonase
EC 3.1.1.69: Now EC 3.5.1.89, N-acetylglucosaminylphosphatidylinositol deacetylase
EC 3.1.1.70: cetraxate benzylesterase
EC 3.1.1.71: acetylalkylglycerol acetylhydrolase
EC 3.1.1.72: acetylxylan esterase
EC 3.1.1.73: feruloyl esterase
EC 3.1.1.74: cutinase
EC 3.1.1.75: poly(3-hydroxybutyrate) depolymerase
EC 3.1.1.76: poly(3-hydroxyoctanoate) depolymerase
EC 3.1.1.77: acyloxyacyl hydrolase
EC 3.1.1.78: polyneuridine-aldehyde esterase
EC 3.1.1.79: hormone-sensitive lipase
EC 3.1.1.80: acetylajmaline esterase
EC 3.1.1.81: quorum-quenching N-acyl-homoserine lactonase
EC 3.1.1.82: pheophorbidase
EC 3.1.1.83: monoterpene ε-lactone hydrolase
EC 3.1.1.84: cocaine esterase
EC 3.1.1.85: pimelyl-(acyl-carrier protein) methyl ester esterase
EC 3.1.1.86: rhamnogalacturonan acetylesterase
EC 3.1.1.87: fumonisin B1 esterase
EC 3.1.1.88: pyrethroid hydrolase
EC 3.1.1.89: protein phosphatase methylesterase-1
EC 3.1.1.90: all-trans-retinyl ester 13-cis isomerohydrolase
EC 3.1.1.91: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase
EC 3.1.1.92: 4-sulfomuconolactone hydrolase
EC 3.1.1.93: mycophenolic acid acyl-glucuronide esterase
EC 3.1.1.94: versiconal hemiacetal acetate esterase *
EC 3.1.1.95: aclacinomycin methylesterase *
EC 3.1.1.96: D-aminoacyl-tRNA deacylase *
EC 3.1.1.97: methylated diphthine methylhydrolase *
EC 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase *
EC 3.1.1.99: 6-deoxy-6-sulfogluconolactonase *
EC 3.1.1.100: chlorophyllide a hydrolase *
EC 3.1.1.101: poly(ethylene terephthalate) hydrolase *
EC 3.1.1.102: mono(ethylene terephthalate) hydrolase *
EC 3.1.1.103: teichoic acid D-alanine hydrolase *
EC 3.1.1.104: 5-phospho-D-xylono-1,4-lactonase *
EC 3.1.1.105: 3-O-acetylpapaveroxine carboxylesterase *
EC 3.1.1.106: O-acetyl-ADP-ribose deacetylase *
EC 3.1.1.107: apo-salmochelin esterase *
EC 3.1.1.108: iron(III)-enterobactin esterase *
EC 3.1.1.109: iron(III)-salmochelin esterase *
EC 3.1.1.110: xylono-1,5-lactonase *
EC 3.1.1.111: phosphatidylserine sn-1 acylhydrolase *
EC 3.1.1.112: isoamyl acetate esterase *
EC 3.1.1.113: ethyl acetate hydrolase *
EC 3.1.1.114: methyl acetate hydrolase *
EC 3.1.1.115: D-apionolactonase *
EC 3.1.1.116: sn-1-specific diacylglycerol lipase *
EC 3.1.1.117: (4-O-methyl)-D-glucuronate—lignin esterase *
EC 3.1.1.118: phospholipid sn-1 acylhydrolase *

*No Wikipedia article

EC 3.1.2: Thioester Hydrolases[edit]

EC 3.1.2.1: acetyl-CoA hydrolase
EC 3.1.2.2: palmitoyl-CoA hydrolase
EC 3.1.2.3: succinyl-CoA hydrolase
EC 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase
EC 3.1.2.5: hydroxymethylglutaryl-CoA hydrolase
EC 3.1.2.6: hydroxyacylglutathione hydrolase
EC 3.1.2.7: glutathione thiolesterase
EC 3.1.2.8: Now included with EC 3.1.2.6 hydroxyacylglutathione hydrolase
EC 3.1.2.9: S-acetoacetylhydrolipoate hydrolase deleted
EC 3.1.2.10: formyl-CoA hydrolase
EC 3.1.2.11: acetoacetyl-CoA hydrolase
EC 3.1.2.12: S-formylglutathione hydrolase
EC 3.1.2.13: S-succinylglutathione hydrolase
EC 3.1.2.14: oleoyl-[acyl-carrier-protein] hydrolase
EC 3.1.2.15: covered by EC 3.4.19.12, ubiquitinyl hydrolase 1
EC 3.1.2.16: citrate lyase deacetylase
EC 3.1.2.17: (S)-methylmalonyl-CoA hydrolase
EC 3.1.2.18: ADP-dependent short-chain-acyl-CoA hydrolase
EC 3.1.2.19: ADP-dependent medium-chain-acyl-CoA hydrolase
EC 3.1.2.20: acyl-CoA hydrolase
EC 3.1.2.21: dodecanoyl-(acyl-carrier-protein) hydrolase
EC 3.1.2.22: palmitoyl[protein] hydrolase
EC 3.1.2.23: 4-hydroxybenzoyl-CoA thioesterase
EC 3.1.2.24: transferred entry now EC 3.13.1.3, 2′-hydroxybiphenyl-2-sulfinate desulfinase.
EC 3.1.2.25: phenylacetyl-CoA hydrolase
EC 3.1.2.26: Now EC 2.8.3.25, bile acid CoA transferase
EC 3.1.2.27: choloyl-CoA hydrolase
EC 3.1.2.28: 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
EC 3.1.2.29: fluoroacetyl-CoA thioesterase
EC 3.1.2.30: (3S)-malyl-CoA thioesterase *
EC 3.1.2.31: dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase *
EC 3.1.2.32: 2-aminobenzoylacetyl-CoA thioesterase *

*No Wikipedia article

EC 3.1.3: Phosphoric Monoester Hydrolases[edit]

EC 3.1.3.1: alkaline phosphatase
EC 3.1.3.2: acid phosphatase
EC 3.1.3.3: phosphoserine phosphatase
EC 3.1.3.4: phosphatidate phosphatase
EC 3.1.3.5: 5′-nucleotidase
EC 3.1.3.6: 3′-nucleotidase
EC 3.1.3.7: 3′(2′),5′-bisphosphate nucleotidase
EC 3.1.3.8: 3-phytase
EC 3.1.3.9: glucose-6-phosphatase
EC 3.1.3.10: glucose-1-phosphatase
EC 3.1.3.11: fructose-bisphosphatase
EC 3.1.3.12: trehalose-phosphatase
EC 3.1.3.13: Recent studies have shown that this is a partial activity of EC 5.4.2.11, phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
EC 3.1.3.14: methylphosphothioglycerate phosphatase
EC 3.1.3.15: histidinol-phosphatase
EC 3.1.3.16: protein serine/threonine phosphatase
EC 3.1.3.17: (phosphorylase) phosphatase
EC 3.1.3.18: phosphoglycolate phosphatase
EC 3.1.3.19: glycerol-2-phosphatase
EC 3.1.3.20: phosphoglycerate phosphatase
EC 3.1.3.21: glycerol-1-phosphatase
EC 3.1.3.22: mannitol-1-phosphatase
EC 3.1.3.23: sugar-phosphatase
EC 3.1.3.24: sucrose-phosphatase
EC 3.1.3.25: inositol-phosphate phosphatase
EC 3.1.3.26: 4-phytase
EC 3.1.3.27: phosphatidylglycerophosphatase
EC 3.1.3.28: ADP-phosphoglycerate phosphatase
EC 3.1.3.29: N-acylneuraminate-9-phosphatase
EC 3.1.3.30: The activity may be that of an acid phosphatase
EC 3.1.3.31: The activity may be that of an acid phosphatase
EC 3.1.3.32: polynucleotide 3′-phosphatase
EC 3.1.3.33: polynucleotide 5′-phosphatase
EC 3.1.3.34: deoxynucleotide 3′-phosphatase
EC 3.1.3.35: thymidylate 5′-phosphatase
EC 3.1.3.36: phosphoinositide 5-phosphatase
EC 3.1.3.37: sedoheptulose-bisphosphatase
EC 3.1.3.38: 3-phosphoglycerate phosphatase
EC 3.1.3.39: streptomycin-6-phosphatase
EC 3.1.3.40: guanidinodeoxy-scyllo-inositol-4-phosphatase
EC 3.1.3.41: 4-nitrophenylphosphatase
EC 3.1.3.42: glycogen-synthase-D] phosphatase
EC 3.1.3.43: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
EC 3.1.3.44: [acetyl-CoA carboxylase]-phosphatase
EC 3.1.3.45: 3-deoxy-manno-octulosonate-8-phosphatase
EC 3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase
EC 3.1.3.47: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
EC 3.1.3.48: protein-tyrosine-phosphatase
EC 3.1.3.49: [pyruvate kinase]-phosphatase
EC 3.1.3.50: sorbitol-6-phosphatase
EC 3.1.3.51: dolichyl-phosphatase
EC 3.1.3.52: [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase
EC 3.1.3.53: [myosin-light-chain] phosphatase
EC 3.1.3.54: fructose-2,6-bisphosphate 6-phosphatase
EC 3.1.3.55: caldesmon-phosphatase
EC 3.1.3.56: inositol-polyphosphate 5-phosphatase
EC 3.1.3.57: inositol-1,4-bisphosphate 1-phosphatase
EC 3.1.3.58: sugar-terminal-phosphatase
EC 3.1.3.59: alkylacetylglycerophosphatase
EC 3.1.3.60: phosphoenolpyruvate phosphatase
EC 3.1.3.61: deleted, as its existence has not been established
EC 3.1.3.62: multiple inositol-polyphosphate phosphatase
EC 3.1.3.63: 2-carboxy-D-arabinitol-1-phosphatase
EC 3.1.3.64: phosphatidylinositol-3-phosphatase
EC 3.1.3.65: Now included with EC 3.1.3.64, phosphatidylinositol-3-phosphatase
EC 3.1.3.66: phosphatidylinositol-3,4-bisphosphate 4-phosphatase
EC 3.1.3.67: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
EC 3.1.3.68: 2-deoxyglucose-6-phosphatase
EC 3.1.3.69: glucosylglycerol 3-phosphatase
EC 3.1.3.70: mannosyl-3-phosphoglycerate phosphatase
EC 3.1.3.71: 2-phosphosulfolactate phosphatase
EC 3.1.3.72: 5-phytase
EC 3.1.3.73: adenosylcobalamin/α-ribazole phosphatase
EC 3.1.3.74: pyridoxal phosphatase
EC 3.1.3.75: phosphoethanolamine/phosphocholine phosphatase
EC 3.1.3.76: lipid-phosphate phosphatase
EC 3.1.3.77: acireductone synthase
EC 3.1.3.78: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
EC 3.1.3.79: mannosylfructose-phosphate phosphatase
EC 3.1.3.80: 2,3-bisphosphoglycerate 3-phosphatase
EC 3.1.3.81: Transferred entry, now EC 3.6.1.75, diacylglycerol diphosphate phosphatase
EC 3.1.3.82: D-glycero-β-D-manno-heptose 1,7-bisphosphate 7-phosphatase
EC 3.1.3.83: D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphatase
EC 3.1.3.84: ADP-ribose 1′′-phosphate phosphatase
EC 3.1.3.85: glucosyl-3-phosphoglycerate phosphatase
EC 3.1.3.86: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
EC 3.1.3.87: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
EC 3.1.3.88: 5′′-phosphoribostamycin phosphatase

* No Wikipedia article

EC 3.1.4: Phosphoric Diester Hydrolases[edit]

EC 3.1.4.1: phosphodiesterase I
EC 3.1.4.2: glycerophosphocholine phosphodiesterase
EC 3.1.4.3: lecithinase C
EC 3.1.4.4: phospholipase D
EC 3.1.4.5: Now EC 3.1.21.1, deoxyribonuclease I
EC 3.1.4.6: Now EC 3.1.22.1, deoxyribonuclease II
EC 3.1.4.7: Now EC 3.1.31.1, micrococcal nuclease
EC 3.1.4.8: Now EC 3.1.27.3, ribonuclease T1
EC 3.1.4.9: Now EC 3.1.30.2, Serratia marcescens nuclease
EC 3.1.4.10: Now EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase
EC 3.1.4.11: phosphoinositide phospholipase C
EC 3.1.4.12: sphingomyelin phosphodiesterase
EC 3.1.4.13: serine-ethanolaminephosphate phosphodiesterase
EC 3.1.4.14: [acyl-carrier-protein] phosphodiesterase
EC 3.1.4.15 : transferred to EC 2.7.7.89, adenylyl-[glutamateammonia ligase] phosphorylase
EC 3.1.4.16: 2′,3′-cyclic-nucleotide 2′-phosphodiesterase
EC 3.1.4.17: 3′,5′-cyclic-nucleotide phosphodiesterase
EC 3.1.4.18: Now EC 3.1.16.1, spleen exonuclease
EC 3.1.4.19: Now EC 3.1.13.3, oligonucleotidase
EC 3.1.4.20: Now EC 3.1.13.1, exoribonuclease II
EC 3.1.4.21: Now EC 3.1.30.1, Aspergillus nuclease S₁
EC 3.1.4.22: Now EC 3.1.27.5, pancreatic ribonuclease
EC 3.1.4.23: Now EC 3.1.27.1, ribonuclease T₂
EC 3.1.4.24: deleted
EC 3.1.4.25: Now EC 3.1.11.1, exodeoxyribonuclease I
EC 3.1.4.26: deleted
EC 3.1.4.27: Now EC 3.1.11.2, exodeoxyribonuclease III
EC 3.1.4.28: Now EC 3.1.11.3, exodeoxyribonuclease (lambda-induced)
EC 3.1.4.29: deleted
EC 3.1.4.30: Now EC 3.1.21.2, deoxyribonuclease IV (phage-T₄-induced)
EC 3.1.4.31: Now EC 3.1.11.4
EC 3.1.4.32: deleted
EC 3.1.4.33: deleted
EC 3.1.4.34: deleted
EC 3.1.4.35: 3′,5′-cyclic-GMP phosphodiesterase
EC 3.1.4.36: Now with EC 3.1.4.43
EC 3.1.4.37: 2′,3′-cyclic-nucleotide 3'-phosphodiesterase
EC 3.1.4.38: glycerophosphocholine cholinephosphodiesterase
EC 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase
EC 3.1.4.40: CMP-N-acylneuraminate phosphodiesterase
EC 3.1.4.41: sphingomyelin phosphodiesterase D
EC 3.1.4.42: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase
EC 3.1.4.43: glycerophosphoinositol inositolphosphodiesterase
EC 3.1.4.44: glycerophosphoinositol glycerophosphodiesterase
EC 3.1.4.45: N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
EC 3.1.4.46: glycerophosphodiester phosphodiesterase
EC 3.1.4.47: Now EC 4.6.1.14, glycosylphosphatidylinositol diacylglycerol-lyase
EC 3.1.4.48: dolichylphosphate-glucose phosphodiesterase
EC 3.1.4.49: dolichylphosphate-mannose phosphodiesterase
EC 3.1.4.50: glycosylphosphatidylinositol phospholipase D
EC 3.1.4.51: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase
EC 3.1.4.53: 3′,5′-cyclic-AMP phosphodiesterase
EC 3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
EC 3.1.4.55: phosphoribosyl 1,2-cyclic phosphate phosphodiesterase *
EC 3.1.4.56: 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase
EC 3.1.4.57: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase *
EC 3.1.4.58: RNA 2′,3′-cyclic 3′-phosphodiesterase *
EC 3.1.4.59: cyclic-di-AMP phosphodiesterase *
EC 3.1.4.60: pApA phosphodiesterase *
EC 3.1.4.61: cyclic 2,3-diphosphoglycerate hydrolase *

*No Wikipedia article

EC 3.1.5: Triphosphoric Monoester Hydrolases[edit]

EC 3.1.5.1: dGTPase

EC 3.1.6: Sulfuric Ester Hydrolases[edit]

EC 3.1.6.1: arylsulfatase (type I)
EC 3.1.6.2: steryl-sulfatase
EC 3.1.6.3: glycosulfatase
EC 3.1.6.4: N-acetylgalactosamine-6-sulfatase
EC 3.1.6.5: deleted
EC 3.1.6.6: choline-sulfatase
EC 3.1.6.7: cellulose-polysulfatase
EC 3.1.6.8: cerebroside-sulfatase
EC 3.1.6.9: chondro-4-sulfatase
EC 3.1.6.10: chondro-6-sulfatase
EC 3.1.6.11: disulfoglucosamine-6-sulfatase
EC 3.1.6.12: N-acetylgalactosamine-6-sulfatase
EC 3.1.6.13: iduronate-2-sulfatase
EC 3.1.6.14: N-acetylglucosamine-6-sulfatase
EC 3.1.6.15: N-sulfoglucosamine-3-sulfatase
EC 3.1.6.16: monomethyl-sulfatase
EC 3.1.6.17: D-lactate-2-sulfatase
EC 3.1.6.19: (R)-specific secondary-alkylsulfatase (type III) *
EC 3.1.6.20: S-sulfosulfanyl-L-cysteine sulfohydrolase *
EC 3.1.6.21: linear primary-alkylsulfatase *
EC 3.1.6.22: branched primary-alkylsulfatase *

*No Wikipedia article

EC 3.1.7: Diphosphoric Monoester Hydrolases[edit]

EC 3.1.7.1: prenyl-diphosphatase
EC 3.1.7.2: guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase
EC 3.1.7.3: monoterpenyl-diphosphatase
EC 3.1.7.4: Now recognized as two enzymes EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase
EC 3.1.7.5: geranylgeranyl diphosphate diphosphatase
EC 3.1.7.6: farnesyl diphosphatase
EC 3.1.7.7: Now EC 4.2.3.194, (–)-drimenol synthase
EC 3.1.7.8: Now known to be a partial activity of EC 2.5.1.153, adenosine tuberculosinyltransferase.
EC 3.1.7.9: Now known to be a partial activity of EC 2.5.1.153, adenosine tuberculosinyltransferase
EC 3.1.7.10: (13E)-labda-7,13-dien-15-ol synthase
EC 3.1.7.11: geranyl diphosphate diphosphatase
EC 3.1.7.12: (+)-kolavelool synthase *

*No Wikipedia article

EC 3.1.8: Phosphoric Triester Hydrolases[edit]

EC 3.1.11: Exodeoxyribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.11.1: exodeoxyribonuclease I
EC 3.1.11.2: exodeoxyribonuclease III
EC 3.1.11.3: exodeoxyribonuclease (lambda-induced)
EC 3.1.11.4: exodeoxyribonuclease (phage SP₃-induced)
EC 3.1.11.5: exodeoxyribonuclease V
EC 3.1.11.6: exodeoxyribonuclease VII
EC 3.1.11.7: Now EC 3.6.1.71, adenosine-5′-diphospho-5′-[DNA] diphosphatase
EC 3.1.11.8: Now EC 3.6.1.70, guanosine-5′-diphospho-5′-[DNA] diphosphatase

EC 3.1.13: Exoribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.14: Exoribonucleases Producing 3'-Phosphomonoesters[edit]

EC 3.1.14.1: yeast ribonuclease

EC 3.1.15: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[edit]

EC 3.1.15.1: venom exonuclease

EC 3.1.16: Exonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[edit]

EC 3.1.16.1: spleen exonuclease

EC 3.1.21: Endodeoxyribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.21.1: deoxyribonuclease I
EC 3.1.21.2: deoxyribonuclease IV
EC 3.1.21.3: type I site-specific deoxyribonuclease
EC 3.1.21.4: type II site-specific deoxyribonuclease
EC 3.1.21.5: type III site-specific deoxyribonuclease
EC 3.1.21.6: CC-preferring endodeoxyribonuclease
EC 3.1.21.7: deoxyribonuclease V
EC 3.1.21.8: T₄ deoxyribonuclease II *
EC 3.1.21.9: T₄ deoxyribonuclease IV *
EC 3.1.21.10: crossover junction endodeoxyribonuclease *

*No Wikipedia article

EC 3.1.22: Endodeoxyribonucleases Producing 3'-Phosphomonoesters[edit]

EC 3.1.22.1: deoxyribonuclease II
EC 3.1.22.2: Aspergillus deoxyribonuclease K1
EC 3.1.22.3: now EC 3.1.21.7
EC 3.1.22.4: crossover junction endodeoxyribonuclease
EC 3.1.22.5: deoxyribonuclease X

EC 3.1.23: and EC 3.1.24 now EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5[edit]

Deleted sub-subclasses.

EC 3.1.25: Site-Specific Endodeoxyribonucleases Specific for Altered Bases[edit]

EC 3.1.25.1: deoxyribonuclease (pyrimidine dimer)
EC 3.1.25.2: Now EC 4.2.99.18, DNA-(apurinic or apyrimidinic site) lyase

EC 3.1.26: Endoribonucleases Producing 5'-Phosphomonoesters[edit]

EC 3.1.27: Endoribonucleases Producing 3'-Phosphomonoesters[edit]

EC 3.1.27.1: Now EC 4.6.1.19, ribonuclease T₂, since the primary reaction is that of a lyase
EC 3.1.27.2: Now EC 4.6.1.22, Bacillus subtilis ribonuclease, since the reaction catalysed is that of a lyase
EC 3.1.27.3: Now EC 4.6.1.24, ribonuclease T₁, since the primary reaction is that of a lyase
EC 3.1.27.4: Now EC 4.6.1.20, ribonuclease U₂, since the primary reaction is that of a lyase
EC 3.1.27.5: Now EC 4.6.1.18, pancreatic ribonuclease.
EC 3.1.27.6: Now EC 4.6.1.21, Enterobacter ribonuclease, since the primary reaction is that of a lyase
EC 3.1.27.7: ribonuclease F
EC 3.1.27.8: ribonuclease V
EC 3.1.27.9: Now EC 4.6.1.16, tRNA-intron lyase
EC 3.1.27.10: Now EC 4.6.1.23, ribotoxin,

EC 3.1.30: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 5'-Phosphomonoesters[edit]

EC 3.1.31: Endoribonucleases Active with either Ribo- or Deoxyribonucleic Acids and Producing 3'-Phosphomonoesters[edit]

EC 3.1.31.1: micrococcal nuclease

EC 3.2: Glycosylases[edit]

EC 3.2.1: Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds[edit]

EC 3.2.1.1: α-amylase
EC 3.2.1.2: β-amylase
EC 3.2.1.3: glucan 1,4-α-glucosidase
EC 3.2.1.4: cellulase
EC 3.2.1.5: deleted
EC 3.2.1.6: endo-1,3(4)-β-glucanase
EC 3.2.1.7: inulinase
EC 3.2.1.8: endo-1,4-β-xylanase
EC 3.2.1.9: deleted
EC 3.2.1.10: oligo-1,6-glucosidase
EC 3.2.1.11: dextranase
EC 3.2.1.12: Now included with EC 3.2.1.54, cyclomaltodextrinase
EC 3.2.1.13: Now included with EC 3.2.1.54, cyclomaltodextrinase
EC 3.2.1.14: chitinase
EC 3.2.1.15: polygalacturonase
EC 3.2.1.16: deleted
EC 3.2.1.17: lysozyme
EC 3.2.1.18: exo-α-sialidase
EC 3.2.1.19: deleted
EC 3.2.1.20: α-glucosidase
EC 3.2.1.21: β-glucosidase
EC 3.2.1.22: α-galactosidase
EC 3.2.1.23: β-galactosidase
EC 3.2.1.24: α-mannosidase
EC 3.2.1.25: β-mannosidase
EC 3.2.1.26: β-fructofuranosidase (invertase)
EC 3.2.1.27: deleted
EC 3.2.1.28: α,α-trehalase
EC 3.2.1.29: Now included with EC 3.2.1.52, β-N-acetylhexosaminidase
EC 3.2.1.30: Now included with EC 3.2.1.52, β-N-acetylhexosaminidase
EC 3.2.1.31: β-glucuronidase
EC 3.2.1.32: endo-1,3-β-xylanase
EC 3.2.1.33: amylo-α-1,6-glucosidase
EC 3.2.1.34: Now included with EC 3.2.1.35, hyaluronoglucosaminidase
EC 3.2.1.35: hyaluronoglucosaminidase
EC 3.2.1.36: hyaluronoglucuronidase
EC 3.2.1.37: xylan 1,4-β-xylosidase
EC 3.2.1.38: β-D-fucosidase
EC 3.2.1.39: glucan endo-1,3-β-D-glucosidase
EC 3.2.1.40: α-L-rhamnosidase
EC 3.2.1.41: pullulanase
EC 3.2.1.42: GDP-glucosidase
EC 3.2.1.43: β-L-rhamnosidase
EC 3.2.1.44: Now EC 3.2.1.211, endo-(13)-fucoidanase and EC 3.2.1.212, endo-(14)-fucoidanase
EC 3.2.1.45: glucosylceramidase
EC 3.2.1.46: galactosylceramidase
EC 3.2.1.47: Now known to be catalyzed by EC 3.2.1.22, α-galactosidase
EC 3.2.1.48: sucrose α-glucosidase
EC 3.2.1.49: α-N-acetylgalactosaminidase
EC 3.2.1.50: α-N-acetylglucosaminidase
EC 3.2.1.51: α-L-fucosidase
EC 3.2.1.52: β-N-acetylhexosaminidase
EC 3.2.1.53: β-N-acetylgalactosaminidase
EC 3.2.1.54: cyclomaltodextrinase
EC 3.2.1.55: non-reducing end α-L-arabinofuranosidase
EC 3.2.1.56: glucuronosyl-disulfoglucosamine glucuronidase
EC 3.2.1.57: isopullulanase
EC 3.2.1.58: glucan 1,3-β-glucosidase
EC 3.2.1.59: glucan endo-1,3-α-glucosidase
EC 3.2.1.60: glucan 1,4-α-maltotetraohydrolase
EC 3.2.1.61: mycodextranase
EC 3.2.1.62: glycosylceramidase
EC 3.2.1.63: 1,2-α-L-fucosidase
EC 3.2.1.64: 2,6-β-fructan 6-levanbiohydrolase
EC 3.2.1.65: levanase
EC 3.2.1.66: Deleted entry: The activity is covered by EC 3.2.1.40, α-L-rhamnosidase
EC 3.2.1.67: galacturan 1,4-α-galacturonidase
EC 3.2.1.68: isoamylase
EC 3.2.1.69: Now included with EC 3.2.1.41, pullulanase
EC 3.2.1.70: glucan 1,6-α-glucosidase
EC 3.2.1.71: glucan endo-1,2-β-glucosidase
EC 3.2.1.72: xylan 1,3-β-xylosidase
EC 3.2.1.73: licheninase
EC 3.2.1.74: glucan 1,4-β-glucosidase
EC 3.2.1.75: glucan endo-1,6-β-glucosidase
EC 3.2.1.76: L-iduronidase
EC 3.2.1.77: mannan 1,2-(1,3)-α-mannosidase
EC 3.2.1.78: mannan endo-1,4-β-mannosidase
EC 3.2.1.79: Now included with EC 3.2.1.55, non-reducing end α-L-arabinofuranosidase
EC 3.2.1.80: fructan β-fructosidase
EC 3.2.1.81: β-agarase
EC 3.2.1.82: exo-poly-α-digalacturonosidas
EC 3.2.1.83: κ-carrageenase
EC 3.2.1.84: glucan 1,3-α-glucosidase
EC 3.2.1.85: 6-phospho-β-galactosidase
EC 3.2.1.86: 6-phospho-β-glucosidase
EC 3.2.1.87: capsular-polysaccharide endo-1,3-α-galactosidase
EC 3.2.1.88: non-reducing end β-L-arabinopyranosidase
EC 3.2.1.89: arabinogalactan endo-β-1,4-galactanase
EC 3.2.1.90: Deleted, not sufficiently characterised.
EC 3.2.1.91: cellulose 1,4-β-cellobiosidase (non-reducing end)
EC 3.2.1.92: peptidoglycan β-N-acetylmuramidase
EC 3.2.1.93: α,α-phosphotrehalase
EC 3.2.1.94: glucan 1,6-α-isomaltosidase
EC 3.2.1.95: dextran 1,6-α-isomaltotriosidase
EC 3.2.1.96: mannosyl-glycoprotein endo-β-N-acetylglucosaminidase
EC 3.2.1.97: endo-α-N-acetylgalactosaminidase
EC 3.2.1.98: glucan 1,4-α-maltohexaosidase
EC 3.2.1.99: arabinan endo-1,5-α-L-arabinanase
EC 3.2.1.100: mannan 1,4-mannobiosidase
EC 3.2.1.101: mannan endo-1,6-α-mannosidase
EC 3.2.1.102: blood-group-substance endo-1,4-β-galactosidase
EC 3.2.1.103: keratan-sulfate endo-1,4-β-galactosidase
EC 3.2.1.104: steryl-β-glucosidase
EC 3.2.1.105: 3α(S)-strictosidine β-glucosidase
EC 3.2.1.106: mannosyl-oligosaccharide glucosidase
EC 3.2.1.107: protein-glucosylgalactosylhydroxylysine glucosidase
EC 3.2.1.108: lactase
EC 3.2.1.109: endogalactosaminidase
EC 3.2.1.110: identical to EC 3.2.1.97, endo-α-N-acetylgalactosaminidase
EC 3.2.1.111: 1,3-α-L-fucosidase
EC 3.2.1.112: 2-deoxyglucosidase
EC 3.2.1.113: mannosyl-oligosaccharide 1,2-α-mannosidase
EC 3.2.1.114: mannosyl-oligosaccharide 1,3-1,6-α-mannosidas
EC 3.2.1.115: branched-dextran exo-1,2-α-glucosidase
EC 3.2.1.116: glucan 1,4-α-maltotriohydrolase
EC 3.2.1.117: amygdalin β-glucosidase
EC 3.2.1.118: prunasin β-glucosidase
EC 3.2.1.119: vicianin β-glucosidase
EC 3.2.1.120: oligoxyloglucan β-glycosidase
EC 3.2.1.121: polymannuronate hydrolase
EC 3.2.1.122: maltose-6′-phosphate glucosidase
EC 3.2.1.123: endoglycosylceramidase
EC 3.2.1.124: 3-deoxy-2-octulosonidase
EC 3.2.1.125: raucaffricine β-glucosidase
EC 3.2.1.126: coniferin β-glucosidase
EC 3.2.1.127: 1,6-α-L-fucosidase
EC 3.2.1.128: glycyrrhizin hydrolase
EC 3.2.1.129: endo-α-sialidase
EC 3.2.1.130: glycoprotein endo-α-1,2-mannosidase
EC 3.2.1.131: xylan α-1,2-glucuronosidase
EC 3.2.1.132: chitosanase
EC 3.2.1.133: glucan 1,4-α-maltohydrolase
EC 3.2.1.134: difructose-anhydride synthase
EC 3.2.1.135: neopullulanase
EC 3.2.1.136: glucuronoarabinoxylan endo-1,4-β-xylanase
EC 3.2.1.137: mannan exo-1,2-1,6-α-mannosidase
EC 3.2.1.138: Now EC 4.2.2.15, anhydrosialidase
EC 3.2.1.139: α-glucuronidase
EC 3.2.1.140: lacto-N-biosidase
EC 3.2.1.141: 4-α-D-{(1→4)-α-D-glucano}trehalose trehalohydrolase
EC 3.2.1.142: limit dextrinase
EC 3.2.1.143: poly(ADP-ribose) glycohydrolase
EC 3.2.1.144: 3-deoxyoctulosonase
EC 3.2.1.145: galactan 1,3-β-galactosidase
EC 3.2.1.146: β-galactofuranosidase
EC 3.2.1.147: thioglucosidase
EC 3.2.1.148: The activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase
EC 3.2.1.149: β-primeverosidase
EC 3.2.1.150: oligoxyloglucan reducing-end-specific cellobiohydrolase
EC 3.2.1.151: xyloglucan-specific endo-β-1,4-glucanase
EC 3.2.1.152: mannosylglycoprotein endo-β-mannosidase
EC 3.2.1.153: fructan β-(2,1)-fructosidase
EC 3.2.1.154: fructan β-(2,6)-fructosidase
EC 3.2.1.155: xyloglucan-specific endo-processive β-1,4-glucanase
EC 3.2.1.156: oligosaccharide reducing-end xylanase
EC 3.2.1.157: ι-carrageenase
EC 3.2.1.158: α-agarase
EC 3.2.1.159: α-neoagaro-oligosaccharide hydrolase
EC 3.2.1.160: identical to EC 3.2.1.155, xyloglucan-specific exo-β-1,4-glucanase
EC 3.2.1.161: β-apiosyl-β-glucosidase
EC 3.2.1.162: λ-carrageenase
EC 3.2.1.163: 1,6-α-D-mannosidase
EC 3.2.1.164: galactan endo-1,6-β-galactosidase
EC 3.2.1.165: exo-1,4-β-D-glucosaminidase
EC 3.2.1.166: heparanase
EC 3.2.1.167: baicalin-β-D-glucuronidase
EC 3.2.1.168: hesperidin 6-O-α-L-rhamnosyl-β-D-glucosidase
EC 3.2.1.169: protein O-GlcNAcas
EC 3.2.1.170: mannosylglycerate hydrolase
EC 3.2.1.171: rhamnogalacturonan hydrolase
EC 3.2.1.172: unsaturated rhamnogalacturonyl hydrolase
EC 3.2.1.173: rhamnogalacturonan galacturonohydrolase
EC 3.2.1.174: rhamnogalacturonan rhamnohydrolase
EC 3.2.1.175: β-D-glucopyranosyl abscisate β-glucosidase
EC 3.2.1.176: cellulose 1,4-β-cellobiosidase (reducing end)
EC 3.2.1.177: α-D-xyloside xylohydrolase
EC 3.2.1.178: β-porphyranase
EC 3.2.1.179: gellan tetrasaccharide unsaturated glucuronyl hydrolase
EC 3.2.1.180: unsaturated chondroitin disaccharide hydrolase
EC 3.2.1.181: galactan endo-β-1,3-galactanase
EC 3.2.1.182: 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside β-D-glucosidase
EC 3.2.1.183: UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
EC 3.2.1.184: UDP-N,N′-diacetylbacillosamine 2-epimerase (hydrolysing)
EC 3.2.1.185: non-reducing end β-L-arabinofuranosidase *
EC 3.2.1.186: protodioscin 26-O-β-D-glucosidase *
EC 3.2.1.187: (Ara-f)3-Hyp β-L-arabinobiosidase *
EC 3.2.1.188: avenacosidase *
EC 3.2.1.189: dioscin glycosidase (diosgenin-forming) *
EC 3.2.1.190: dioscin glycosidase (3-O-β-D-Glc-diosgenin-forming) *
EC 3.2.1.191: ginsenosidase type III *
EC 3.2.1.192: ginsenoside Rb1 β-glucosidase *
EC 3.2.1.193: ginsenosidase type I *
EC 3.2.1.194: ginsenosidase type IV *
EC 3.2.1.195: 20-O-multi-glycoside ginsenosidase *
EC 3.2.1.196: limit dextrin α-1,6-maltotetraose-hydrolase *
EC 3.2.1.197: β-1,2-mannosidase *
EC 3.2.1.198: α-mannan endo-1,2-α-mannanase *
EC 3.2.1.199: sulfoquinovosidase *
EC 3.2.1.200: exo-chitinase (non-reducing end) *
EC 3.2.1.201: exo-chitinase (reducing end) *
EC 3.2.1.202: endo-chitodextinase *
EC 3.2.1.203: carboxymethylcellulase *
EC 3.2.1.204: 1,3-α-isomaltosidase *
EC 3.2.1.205: isomaltose glucohydrolase *
EC 3.2.1.206: oleuropein β-glucosidase *
EC 3.2.1.207: mannosyl-oligosaccharide α-1,3-glucosidase *
EC 3.2.1.208: glucosylglycerate hydrolase *
EC 3.2.1.209: endoplasmic reticulum Man9GlcNAc2 1,2-α-mannosidase *
EC 3.2.1.210: endoplasmic reticulum Man8GlcNAc2 1,2-α-mannosidase *
EC 3.2.1.211: endo-(1→3)-fucoidanase *
EC 3.2.1.212: endo-(1→4)-fucoidanase *
EC 3.2.1.213: galactan exo-1,6-β-galactobiohydrolase (non-reducing end) *
EC 3.2.1.214: exo β-1,2-glucooligosaccharide sophorohydrolase (non-reducing end) *

*No Wikipedia article

EC 3.2.2: Hydrolysing N-Glycosyl Compounds[edit]

EC 3.2.2.1: purine nucleosidase
EC 3.2.2.2: inosine nucleosidase
EC 3.2.2.3: uridine nucleosidase
EC 3.2.2.4: AMP nucleosidase
EC 3.2.2.5: NAD⁺ glycohydrolase
EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
EC 3.2.2.7: adenosine nucleosidase
EC 3.2.2.8: ribosylpyrimidine nucleosidase
EC 3.2.2.9: adenosylhomocysteine nucleosidase
EC 3.2.2.10: pyrimidine-5′-nucleotide nucleosidase
EC 3.2.2.11: β-aspartyl-N-acetylglucosaminidase
EC 3.2.2.12: inosinate nucleosidase
EC 3.2.2.13: 1-methyladenosine nucleosidase
EC 3.2.2.14: NMN nucleosidase
EC 3.2.2.15: DNA-deoxyinosine glycosylase
EC 3.2.2.16: methylthioadenosine nucleosidase
EC 3.2.2.17: deoxyribodipyrimidine endonucleosidase
EC 3.2.2.18: Now included with EC 3.5.1.52, peptide-N⁴-(N-acetyl-β-glucosaminyl)asparagine amidase
EC 3.2.2.19: ADP-ribosylarginine hydrolase
EC 3.2.2.20: DNA-3-methyladenine glycosylase I
EC 3.2.2.21: DNA-3-methyladenine glycosylase II, MAG1
EC 3.2.2.22: rRNA 'N-glycosylase
EC 3.2.2.23: DNA-formamidopyrimidine glycosylase
EC 3.2.2.24: ADP-ribosyl-[dinitrogen reductase] hydrolase
EC 3.2.2.25: N-methyl nucleosidase
EC 3.2.2.26: futalosine hydrolase
EC 3.2.2.27: uracil-DNA glycosylase
EC 3.2.2.28: double-stranded uracil-DNA glycosylase
EC 3.2.2.29: thymine-DNA glycosylase
EC 3.2.2.30: aminodeoxyfutalosine nucleosidase *
EC 3.2.2.31: adenine glycosylase *

*No Wikipedia article

EC 3.2.3: Hydrolysing S-Glycosyl Compounds[edit]

Deleted sub-subclass

EC 3.3: Acting on Ether Bonds[edit]

EC 3.3.1: Thioether and trialkylsulfonium hydrolases[edit]

EC 3.3.1.1: adenosylhomocysteinase
EC 3.3.1.2: S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
EC 3.3.1.3: The activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase

EC 3.3.2: Ether Hydrolases[edit]

EC 3.3.2.1: isochorismatase
EC 3.3.2.2: alkenylglycerophosphocholine hydrolase
EC 3.3.2.3: Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10)
EC 3.3.2.4: trans-epoxysuccinate hydrolase
EC 3.3.2.5: Now included in EC 3.3.2.2, lysoplasmalogenase
EC 3.3.2.6: leukotriene-A₄ hydrolase
EC 3.3.2.7: hepoxilin-epoxide hydrolase
EC 3.3.2.8: limonene-1,2-epoxide hydrolase
EC 3.3.2.9: microsomal epoxide hydrolase
EC 3.3.2.10: soluble epoxide hydrolase
EC 3.3.2.11: cholesterol-5,6-oxide hydrolase
EC 3.3.2.12: oxepin-CoA hydrolase *
EC 3.3.2.13: chorismatase *
EC 3.3.2.14: 2,4-dinitroanisole O-demethylase *
EC 3.3.2.15: trans-2,3-dihydro-3-hydroxyanthranilic acid synthase *

*No Wikipedia article

EC 3.4: Acting on peptide bonds – Peptidase[edit]

EC 3.4.1 α-amino acyl peptide hydrolases (discontinued)[edit]

EC 3.4.1.1: Now EC 3.4.11.1, leucyl aminopeptidase
EC 3.4.1.2: Now EC 3.4.11.2, membrane alanyl aminopeptidase
EC 3.4.1.3: Now EC 3.4.11.4, tripeptide aminopeptidase
EC 3.4.1.4: Now EC 3.4.11.5, prolyl aminopeptidase

EC 3.4.2 Peptidyl amino acid hydrolases (discontinued)[edit]

EC 3.4.2.1: Now EC 3.4.17.1, carboxypeptidase A
EC 3.4.2.2: Now EC 3.4.17.2, carboxypeptidase B
EC 3.4.2.3: Now EC 3.4.17.4, Gly-Xaa carboxypeptidase

EC 3.4.3: Dipeptide hydrolases (deleted sub-subclass)[edit]

EC 3.4.3.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.3.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.3.3: Now EC 3.4.13.3, Xaa-His dipeptidase
EC 3.4.3.4: Now EC 3.4.13.5, Xaa-methyl-His dipeptidase
EC 3.4.3.5: Now EC 3.4.11.2, membrane alanyl aminopeptidase
EC 3.4.3.6: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.3.7: Now EC 3.4.13.9, Xaa-Pro dipeptidase

EC 3.4.4 Peptidyl Peptide Hydrolases (discontinued)[edit]

EC 3.4.4.1: Now EC 3.4.23.1, pepsin A
EC 3.4.4.2: Now EC 3.4.23.2, pepsin B
EC 3.4.4.3: Now EC 3.4.23.4, chymosin
EC 3.4.4.4: Now EC 3.4.21.4, trypsin
EC 3.4.4.5: Now EC 3.4.21.1, chymotrypsin
EC 3.4.4.6: Now EC 3.4.21.1, chymotrypsin
EC 3.4.4.7: Now covered by EC 3.4.21.36, pancreatic elastase and EC 3.4.21.37, leukocyte elastase
EC 3.4.4.8: Now EC 3.4.21.9, enteropeptidase
EC 3.4.4.9: Now EC 3.4.14.1, dipeptidyl-peptidase I
EC 3.4.4.10: Now EC 3.4.22.2, papain
EC 3.4.4.11: Now EC 3.4.22.6, chymopapain
EC 3.4.4.12: Now EC 3.4.22.3, ficain
EC 3.4.4.13: Now EC 3.4.21.5, thrombin
EC 3.4.4.14: Now EC 3.4.21.7, plasmin
EC 3.4.4.15: Now EC 3.4.23.15, renin
EC 3.4.4.16: Now covered by the microbial serine proteinases EC 3.4.21.62 (subtilisin), EC 3.4.21.63 (oryzin), EC 3.4.21.64 (endopeptidase K), EC 3.4.21.65 (thermomycolin), EC 3.4.21.66 (thermitase) and EC 3.4.21.67 (endopeptidase So)
EC 3.4.4.17: Now covered by the microbial aspartic proteinases EC 3.4.23.20 (penicillopepsin), EC 3.4.23.21 (rhizopuspepsin), EC 3.4.23.22 (endothiapepsin), EC 3.4.23.23 (mucorpepsin), EC 3.4.23.24 (candidapepsin), EC 3.4.23.25 (saccharopepsin), EC 3.4.23.26 (rhodotorulapepsin), EC 3.4.21.103 (physarolisin), EC 3.4.23.28 (acrocylindropepsin), EC 3.4.23.29 (polyporopepsin) and EC 3.4.23.30 (pycnoporopepsin)
EC 3.4.4.18: Now EC 3.4.22.10, streptopain
EC 3.4.4.19: Now EC 3.4.24.3, microbial collagenase
EC 3.4.4.20: Now EC 3.4.22.8, clostripain
EC 3.4.4.21: Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein)
EC 3.4.4.22: Now EC 3.4.23.3, gastricsin
EC 3.4.4.23: Now EC 3.4.23.5, cathepsin D
EC 3.4.4.24: Now covered by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain)
EC 3.4.4.25: deleted

EC 3.4.11 Aminopeptidases[edit]

EC 3.4.11.1: leucyl aminopeptidase
EC 3.4.11.2: membrane alanyl aminopeptidase
EC 3.4.11.3: cystinyl aminopeptidase
EC 3.4.11.4: tripeptide aminopeptidase
EC 3.4.11.5: prolyl aminopeptidase
EC 3.4.11.6: aminopeptidase B
EC 3.4.11.7: glutamyl aminopeptidase
EC 3.4.11.8: Now EC 3.4.19.3, pyroglutamyl-peptidase I
EC 3.4.11.9: Xaa-Pro aminopeptidase
EC 3.4.11.10: bacterial leucyl aminopeptidase
EC 3.4.11.11: Deleted
EC 3.4.11.12: Deleted
EC 3.4.11.13: Clostridial aminopeptidase
EC 3.4.11.14: cytosol alanyl aminopeptidase
EC 3.4.11.15: aminopeptidase Y
EC 3.4.11.16: Xaa-Trp aminopeptidase
EC 3.4.11.17: tryptophanyl aminopeptidase
EC 3.4.11.18: methionyl aminopeptidase
EC 3.4.11.19: D-stereospecific aminopeptidase
EC 3.4.11.20: aminopeptidase Ey
EC 3.4.11.21: aspartyl aminopeptidase
EC 3.4.11.22: aminopeptidase I
EC 3.4.11.23: PepB aminopeptidase
EC 3.4.11.24: aminopeptidase S
EC 3.4.11.25: β-peptidyl aminopeptidase
EC 3.4.11.26: intermediate cleaving peptidase 55

EC 3.4.12 Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass)[edit]

EC 3.4.12.1: Now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
EC 3.4.12.2: Now EC 3.4.17.1, carboxypeptidase A
EC 3.4.12.3: Now EC 3.4.17.2, carboxypeptidase B
EC 3.4.12.4: Now EC 3.4.16.2, lysosomal Pro-Xaa carboxypeptidase
EC 3.4.12.5: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
EC 3.4.12.6: Now EC 3.4.17.8, muramoyl-pentapeptidase carboxypeptidase
EC 3.4.12.7: Now EC 3.4.17.3, lysine carboxypeptidase
EC 3.4.12.8: Now EC 3.4.17.4, Gly-Xaa carboxypeptidase
EC 3.4.12.9: aspartate carboxypeptidase
EC 3.4.12.10: Now EC 3.4.19.9, γ-glutamyl hydrolase
EC 3.4.12.11: Now EC 3.4.17.6, alanine carboxypeptidase
EC 3.4.12.12: Now EC 3.4.16.5 (carboxypeptidase C) and EC 3.4.16.6 (carboxypeptidase D)
EC 3.4.12.13: γ-glutamylglutamate carboxypeptidase

EC 3.4.13 Dipeptidases[edit]

EC 3.4.13.1: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.13.2: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.13.3: The activity is covered by EC .4.13.18, cytosol nonspecific dipeptidase and EC 3.4.13.20, β-Ala-His dipeptidase
EC 3.4.13.4: Xaa-Arg dipeptidase
EC 3.4.13.5: Xaa-methyl-His dipeptidase
EC 3.4.13.6: Now EC 3.4.11.2, membrane alanyl aminopeptidase
EC 3.4.13.7: Glu-Glu dipeptidase
EC 3.4.13.8: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.13.9: Xaa-Pro dipeptidase
EC 3.4.13.10: Now EC 3.4.19.5, β-aspartyl-peptidase
EC 3.4.13.11: Now EC 3.4.13.19, membrane dipeptidase
EC 3.4.13.12: Met-Xaa dipeptidase
EC 3.4.13.13: Now EC 3.4.13.3, Xaa-His dipeptidase
EC 3.4.13.14: Deleted
EC 3.4.13.15: Now EC 3.4.13.18, cytosol nonspecific dipeptidase
EC 3.4.13.16: Deleted
EC 3.4.13.17: non-stereospecific dipeptidase
EC 3.4.13.18: cytosol nonspecific dipeptidase
EC 3.4.13.19: membrane dipeptidase
EC 3.4.13.20: β-Ala-His dipeptidase
EC 3.4.13.21: dipeptidase E
EC 3.4.13.22: D-Ala-D-Ala dipeptidase
EC 3.4.13.23: cysteinylglycine-S-conjugate dipeptidase *

*No Wikipedia article

EC 3.4.14 Dipeptidyl peptidases and tripeptidyl peptidases[edit]

EC 3.4.14.1: dipeptidyl-peptidase I
EC 3.4.14.2: dipeptidyl-peptidase II
EC 3.4.14.3: Now EC 3.4.19.1, acylaminoacyl-peptidase
EC 3.4.14.4: dipeptidyl-peptidase III
EC 3.4.14.5: dipeptidyl-peptidase IV
EC 3.4.14.6: dipeptidyl-dipeptidase
EC 3.4.14.7: Deleted
EC 3.4.14.8: Now EC 3.4.14.10, tripeptidyl-peptidase II
EC 3.4.14.9: tripeptidyl-peptidase I
EC 3.4.14.10: tripeptidyl-peptidase II
EC 3.4.14.11: Xaa-Pro dipeptidyl-peptidase
EC 3.4.14.12: Xaa-Xaa-Pro tripeptidyl-peptidase
EC 3.4.14.13: γ-D-glutamyl-Llysine dipeptidyl-peptidase
EC 3.4.14.14: [mycofactocin precursor peptide] peptidase *

*No Wikipedia article

EC 3.4.15 Peptidyl dipeptidases[edit]

EC 3.4.15.1: peptidyl-dipeptidase A
EC 3.4.15.2: Now EC 3.4.19.2, peptidyl-glycinamidase
EC 3.4.15.3: Now EC 3.4.15.5, peptidyl-dipeptidase Dcp
EC 3.4.15.4: Peptidyl-dipeptidase B
EC 3.4.15.5: Peptidyl-dipeptidase Dcp
EC 3.4.15.6: cyanophycinase

EC 3.4.16 Serine type carboxypeptidases[edit]

EC 3.4.16.1: Transferred entry: serine carboxypeptidase. Now EC 3.4.16.6, carboxypeptidase D
EC 3.4.16.2: lysosomal Pro-Xaa carboxypeptidase
EC 3.4.16.3: Now included with EC 3.4.16.5, carboxypeptidase C
EC 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase
EC 3.4.16.5: carboxypeptidase C
EC 3.4.16.6: carboxypeptidase D

EC 3.4.17 Metallocarboxypeptidases[edit]

EC 3.4.17.1: carboxypeptidase A
EC 3.4.17.2: carboxypeptidase B
EC 3.4.17.3: lysine carboxypeptidase
EC 3.4.17.4: Gly-Xaa carboxypeptidase
EC 3.4.17.5: Deleted
EC 3.4.17.6: alanine carboxypeptidase
EC 3.4.17.7: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
EC 3.4.17.8: muramoylpentapeptide carboxypeptidase
EC 3.4.17.9: Now included with EC 3.4.17.4, Gly-Xaa carboxypeptidase
EC 3.4.17.10: carboxypeptidase E
EC 3.4.17.11: glutamate carboxypeptidase
EC 3.4.17.12: carboxypeptidase M
EC 3.4.17.13: Muramoyltetrapeptide carboxypeptidase
EC 3.4.17.14: zinc D-Ala-D-Ala carboxypeptidase
EC 3.4.17.15: carboxypeptidase A₂
EC 3.4.17.16: membrane Pro-Xaa carboxypeptidase
EC 3.4.17.17: tubulinyl-Tyr carboxypeptidase
EC 3.4.17.18: carboxypeptidase T
EC 3.4.17.19: Carboxypeptidase Taq
EC 3.4.17.20: carboxypeptidase U
EC 3.4.17.21: Glutamate carboxypeptidase II
EC 3.4.17.22: metallocarboxypeptidase D
EC 3.4.17.23: angiotensin-converting enzyme 2
EC 3.4.17.24: tubulin-glutamate carboxypeptidase *

*No Wikipedia article

EC 3.4.18 Cysteine type carboxypeptidases[edit]

EC 3.4.18.1: cathepsin X

EC 3.4.19 Omega peptidases[edit]

EC 3.4.19.1: acylaminoacyl-peptidase
EC 3.4.19.2: peptidyl-glycinamidase
EC 3.4.19.3: pyroglutamyl-peptidase I
EC 3.4.19.4: Deleted
EC 3.4.19.5: β-aspartyl-peptidase
EC 3.4.19.6: pyroglutamyl-peptidase II
EC 3.4.19.7: N-formylmethionyl-peptidase
EC 3.4.19.8: now EC 3.4.17.21, glutamate carboxypeptidase II
EC 3.4.19.9: folate γ-glutamyl hydrolase
EC 3.4.19.10: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase
EC 3.4.19.11: γ-Dglutamyl-meso-diaminopimelate peptidase
EC 3.4.19.12: ubiquitinyl hydrolase 1
EC 3.4.19.13: glutathione γ-glutamate hydrolase
EC 3.4.19.14: leukotriene-C₄ hydrolase
EC 3.4.19.15: desampylase *
EC 3.4.19.16: glucosinolate γ-glutamyl hydrolase *

*No Wikipedia article

EC 3.4.21: Serine proteases[edit]

EC 3.4.21.1: chymotrypsin
EC 3.4.21.2: chymotrypsin C
EC 3.4.21.3: metridin
EC 3.4.21.4: trypsin
EC 3.4.21.5: thrombin
EC 3.4.21.6: coagulation factor Xa
EC 3.4.21.7: plasmin
EC 3.4.21.8: Now EC 3.4.21.34 (plasma kallikrein) and EC 3.4.21.35 (tissue kallikrein)
EC 3.4.21.9: enteropeptidase
EC 3.4.21.10: acrosin
EC 3.4.21.11: Now EC 3.4.21.37, leukocyte elastase
EC 3.4.21.12: α-lytic endopeptidase
EC 3.4.21.13: Now EC 3.4.16.6, carboxypeptidase D
EC 3.4.21.14: now EC 3.4.21.67, endopeptidase So
EC 3.4.21.15: Now EC 3.4.21.63, oryzin
EC 3.4.21.16: Deleted
EC 3.4.21.17: Deleted
EC 3.4.21.18: Deleted
EC 3.4.21.19: glutamyl endopeptidase
EC 3.4.21.20: cathepsin G
EC 3.4.21.21: coagulation factor VIIa
EC 3.4.21.22: coagulation factor IXa
EC 3.4.21.23: Deleted
EC 3.4.21.24: Deleted
EC 3.4.21.25: cucumisin
EC 3.4.21.26: prolyl oligopeptidase
EC 3.4.21.27: coagulation factor XIa
EC 3.4.21.28: Now EC 3.4.21.74, venombin A
EC 3.4.21.29: Now EC 3.4.21.74, venombin A
EC 3.4.21.30: Now EC 3.4.21.74, venombin A
EC 3.4.21.31: Now EC 3.4.21.73, u-plasminogen activator
EC 3.4.21.32: brachyurin
EC 3.4.21.33: Deleted
EC 3.4.21.34: plasma kallikrein
EC 3.4.21.35: tissue kallikrein
EC 3.4.21.36: pancreatic elastase
EC 3.4.21.37: leukocyte elastase
EC 3.4.21.38: coagulation factor XIIa
EC 3.4.21.39: chymase
EC 3.4.21.40: Deleted
EC 3.4.21.41: Complement subcomponent C^1r
EC 3.4.21.42: complement subcomponent C^1s
EC 3.4.21.43: classical-complement-pathway C3/C5 convertase
EC 3.4.21.44: Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase
EC 3.4.21.45: complement factor I
EC 3.4.21.46: complement factor D
EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase
EC 3.4.21.48: cerevisin
EC 3.4.21.49: hypodermin C
EC 3.4.21.50: lysyl endopeptidase
EC 3.4.21.51: Deleted
EC 3.4.21.52: Deleted
EC 3.4.21.53: edopeptidase La
EC 3.4.21.54: γ-renin
EC 3.4.21.55: venombin AB
EC 3.4.21.56: Now considered to be EC 3.4.21.25, cucumisin
EC 3.4.21.57: leucyl endopeptidase
EC 3.4.21.58: Deleted
EC 3.4.21.59: tryptase
EC 3.4.21.60: scutelarin
EC 3.4.21.61: kexin
EC 3.4.21.62: subtilisin
EC 3.4.21.63: oryzin
EC 3.4.21.64: endopeptidase K
EC 3.4.21.65: thermomycolin
EC 3.4.21.66: thermitase
EC 3.4.21.67: endopeptidase So
EC 3.4.21.68: t-plasminogen activator
EC 3.4.21.69: protein C (activated)
EC 3.4.21.70: pancreatic endopeptidase E
EC 3.4.21.71: pancreatic elastase II
EC 3.4.21.72: IgA-specific serine endopeptidase
EC 3.4.21.73: u-plasminogen activator
EC 3.4.21.74: venombin A
EC 3.4.21.75: furin
EC 3.4.21.76: myeloblastin
EC 3.4.21.77: semenogelase
EC 3.4.21.78: granzyme A
EC 3.4.21.79: granzyme B
EC 3.4.21.80: streptogrisin A
EC 3.4.21.81: streptogrisin B
EC 3.4.21.82: glutamyl endopeptidase II
EC 3.4.21.83: oligopeptidase B
EC 3.4.21.84: limulus clotting factor C
EC 3.4.21.85: limulus clotting factor B
EC 3.4.21.86: limulus clotting enzyme
EC 3.4.21.87: Now EC 3.4.23.49, omptin
EC 3.4.21.88: repressor LexA
EC 3.4.21.89: signal peptidase I
EC 3.4.21.90: togavirin
EC 3.4.21.91: flavivirin
EC 3.4.21.92: endopeptidase Clp
EC 3.4.21.93: proprotein convertase 1
EC 3.4.21.94: proprotein convertase 2
EC 3.4.21.95: snake venom factor V activator
EC 3.4.21.96: lactocepin
EC 3.4.21.97: assemblin
EC 3.4.21.98: hepacivirin
EC 3.4.21.99: spermosin
EC 3.4.21.100: sedolisin
EC 3.4.21.101: xanthomonalisin
EC 3.4.21.102: C-terminal processing peptidase
EC 3.4.21.103: physarolisin
EC 3.4.21.104: mannan-binding lectin-associated serine protease-2
EC 3.4.21.105: rhomboid protease
EC 3.4.21.106: hepsin
EC 3.4.21.107: peptidase Do
EC 3.4.21.108: HtrA2 peptidase
EC 3.4.21.109: matriptase
EC 3.4.21.110: C5a peptidase
EC 3.4.21.111: aqualysin 1
EC 3.4.21.112: site-1 protease
EC 3.4.21.113: pestivirus NS3 polyprotein peptidase
EC 3.4.21.114: equine arterivirus serine peptidase
EC 3.4.21.115: infectious pancreatic necrosis birnavirus Vp4 peptidase
EC 3.4.21.116: SpoIVB peptidase
EC 3.4.21.117: stratum corneum chymotryptic enzyme
EC 3.4.21.118: kallikrein 8
EC 3.4.21.119: kallikrein 13
EC 3.4.21.120: oviductin
EC 3.4.21.121: Lys-Lys/Arg-Xaa endopeptidase *

*No Wikipedia article

EC 3.4.22 Cysteine proteases[edit]

EC 3.4.22.1: cathepsin B
EC 3.4.22.2: papain
EC 3.4.22.3: ficain
EC 3.4.22.4: Now EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain)
EC 3.4.22.5: Now EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain)
EC 3.4.22.6: chymopapain
EC 3.4.22.7: asclepain
EC 3.4.22.8: clostripain
EC 3.4.22.9: Now EC 3.4.21.48, cerevisin
EC 3.4.22.10: streptopain
EC 3.4.22.11: Now EC 3.4.24.56, insulysin
EC 3.4.22.12: Now EC 3.4.19.9, γ-glutamyl hydrolase
EC 3.4.22.13: Deleted
EC 3.4.22.14: actinidain
EC 3.4.22.15: cathepsin L
EC 3.4.22.16: cathepsin H
EC 3.4.22.17: Now EC 3.4.22.53, calpain-2
EC 3.4.22.18: Now EC 3.4.21.26, prolyl oligopeptidase
EC 3.4.22.19: Now EC 3.4.24.15, thimet oligopeptidase
EC 3.4.22.20: Deleted
EC 3.4.22.21: Now EC 3.4.25.1, proteasome endopeptidase complex
EC 3.4.22.22: Now EC 3.4.24.37, saccharolysin
EC 3.4.22.23: Now EC 3.4.21.61, kexin
EC 3.4.22.24: Cathepsin T
EC 3.4.22.25: Glycyl endopeptidase
EC 3.4.22.26: Cancer procoagulant
EC 3.4.22.27: cathepsin S
EC 3.4.22.28: picornain 3C
EC 3.4.22.29: picornain 2A
EC 3.4.22.30: Caricain
EC 3.4.22.31: Ananain
EC 3.4.22.32: Stem bromelain
EC 3.4.22.33: Fruit bromelain
EC 3.4.22.34: Legumain
EC 3.4.22.35: Histolysain
EC 3.4.22.36: caspase-1
EC 3.4.22.37: Gingipain R
EC 3.4.22.38: Cathepsin K
EC 3.4.22.39: adenain
EC 3.4.22.40: bleomycin hydrolase
EC 3.4.22.41: cathepsin F
EC 3.4.22.42: cathepsin O
EC 3.4.22.43: cathepsin V
EC 3.4.22.44: nuclear-inclusion-a endopeptidase
EC 3.4.22.45: helper-component proteinase
EC 3.4.22.46: L-peptidase
EC 3.4.22.47: gingipain K
EC 3.4.22.48: staphopain
EC 3.4.22.49: separase
EC 3.4.22.50: V-cath endopeptidase
EC 3.4.22.51: cruzipain
EC 3.4.22.52: calpain-1
EC 3.4.22.53: calpain-2
EC 3.4.22.54: calpain-3
EC 3.4.22.55: caspase-2
EC 3.4.22.56: caspase-3
EC 3.4.22.57: caspase-4
EC 3.4.22.58: caspase-5
EC 3.4.22.59: caspase-6
EC 3.4.22.60: caspase-7
EC 3.4.22.61: caspase-8
EC 3.4.22.62: caspase-9
EC 3.4.22.63: caspase-10
EC 3.4.22.64: caspase-11
EC 3.4.22.65: peptidase 1 (mite)
EC 3.4.22.66: calicivirin
EC 3.4.22.67: zingipain
EC 3.4.22.68: Ulp1 peptidase
EC 3.4.22.69: SARS coronavirus main proteinase
EC 3.4.22.70: sortase A
EC 3.4.22.71: sortase B

EC 3.4.23 Aspartic endopeptidases[edit]

EC 3.4.23.1: pepsin A
EC 3.4.23.2: pepsin B
EC 3.4.23.3: gastricsin
EC 3.4.23.4: chymosin
EC 3.4.23.5: cathepsin D
EC 3.4.23.6: Now EC 3.4.23.30, pycnoporopepsin
EC 3.4.23.7: Now EC 3.4.23.20, penicillopepsin
EC 3.4.23.8: Now EC 3.4.23.25, saccharopepsin
EC 3.4.23.9: Now EC 3.4.23.21, rhizopuspepsin
EC 3.4.23.10: Now EC 3.4.23.22, endothiapepsin
EC 3.4.23.11: Deleted entry
EC 3.4.23.12: nepenthesin
EC 3.4.23.13: Deleted
EC 3.4.23.14: Deleted
EC 3.4.23.15: renin
EC 3.4.23.16: HIV-1 retropepsin
EC 3.4.23.17: pro-opiomelanocortin converting enzyme
EC 3.4.23.18: aspergillopepsin I
EC 3.4.23.19: aspergillopepsin II
EC 3.4.23.20: penicillopepsin
EC 3.4.23.21: rhizopuspepsin
EC 3.4.23.22: endothiapepsin
EC 3.4.23.23: mucorpepsin
EC 3.4.23.24: candidapepsin
EC 3.4.23.25: saccharopepsin
EC 3.4.23.26: rhodotorulapepsin
EC 3.4.23.27: Now EC 3.4.21.103, physarolisin
EC 3.4.23.28: acrocylindropepsin
EC 3.4.23.29: polyporopepsin
EC 3.4.23.30: pycnoporopepsin
EC 3.4.23.31: scytalidopepsin A
EC 3.4.23.32: scytalidopepsin B
EC 3.4.23.33: Now EC 3.4.21.101, xanthomonalisin
EC 3.4.23.34: cathepsin E
EC 3.4.23.35: barrierpepsin
EC 3.4.23.36: signal peptidase II
EC 3.4.23.37: Now EC 3.4.21.100, pseudomonalisin
EC 3.4.23.38: plasmepsin I
EC 3.4.23.39: plasmepsin II
EC 3.4.23.40: phytepsin
EC 3.4.23.41: yapsin 1
EC 3.4.23.42: thermopsin
EC 3.4.23.43: prepilin peptidase
EC 3.4.23.44: nodavirus endopeptidase
EC 3.4.23.45: memapsin 1
EC 3.4.23.46: memapsin 2
EC 3.4.23.47: HIV-2 retropepsin
EC 3.4.23.48: plasminogen activator Pla
EC 3.4.23.49: omptin
EC 3.4.23.50: human endogenous retrovirus K endopeptidase
EC 3.4.23.51: HycI peptidase
EC 3.4.23.52: preflagellin peptidase

EC 3.4.24: Metallopeptidases[edit]

EC 3.4.24.1: atrolysin A
EC 3.4.24.2: Deleted entry: Sepia proteinase
EC 3.4.24.3: microbial collagenase
EC 3.4.24.4: now EC 3.4.24.40 serralysin
EC 3.4.24.5: Deleted entry: lens neutral proteinase. Now included with EC 3.4.22.53 (calpain-2) and EC 3.4.25.1 (proteasome endopeptidase complex)
EC 3.4.24.6: leucolysin
EC 3.4.24.7: interstitial collagenase
EC 3.4.24.8: Transferred entry: Achromobacter iophagus collagenase. Now EC 3.4.24.3, microbial collagenase
EC 3.4.24.9: Deleted entry: Trichophyton schoenleinii collagenase
EC 3.4.24.10: Deleted entry: Trichophyton mentagrophytes keratinase
EC 3.4.24.11: neprilysin
EC 3.4.24.12: envelysin
EC 3.4.24.13: IgA-specific metalloendopeptidase
EC 3.4.24.14: procollagen N-endopeptidase
EC 3.4.24.15: thimet oligopeptidase
EC 3.4.24.16: neurolysin
EC 3.4.24.17: stromelysin 1
EC 3.4.24.18: meprin A
EC 3.4.24.19: procollagen C-endopeptidase
EC 3.4.24.20: peptidyl-Lys metalloendopeptidase
EC 3.4.24.21: astacin
EC 3.4.24.22: stromelysin 2
EC 3.4.24.23: matrilysin
EC 3.4.24.24: gelatinase a
EC 3.4.24.25: vibriolysin
EC 3.4.24.26: pseudolysin
EC 3.4.24.27: thermolysin
EC 3.4.24.28: bacillolysin
EC 3.4.24.29: aureolysin
EC 3.4.24.30: coccolysin
EC 3.4.24.31: mycolysin
EC 3.4.24.32: β-lytic metalloendopeptidase
EC 3.4.24.33: peptidyl-Asp metalloendopeptidase
EC 3.4.24.34: neutrophil collagenase
EC 3.4.24.35: gelatinase B
EC 3.4.24.36: leishmanolysin
EC 3.4.24.37: saccharolysin
EC 3.4.24.38: gametolysin
EC 3.4.24.39: deuterolysin
EC 3.4.24.40: serralysin
EC 3.4.24.41: atrolysin B
EC 3.4.24.42: atrolysin C
EC 3.4.24.43: atroxase
EC 3.4.24.44: atrolysin E
EC 3.4.24.45: atrolysin F
EC 3.4.24.46: adamalysin
EC 3.4.24.47: horrilysin
EC 3.4.24.48: ruberlysin
EC 3.4.24.49: bothropasin
EC 3.4.24.50: bothrolysin
EC 3.4.24.51: ophiolysin
EC 3.4.24.52: trimerelysin I
EC 3.4.24.53: trimerelysin II
EC 3.4.24.54: mucrolysin
EC 3.4.24.55: pitrilysin
EC 3.4.24.56: insulysin
EC 3.4.24.57: O-sialoglycoprotein endopeptidase
EC 3.4.24.58: russellysin
EC 3.4.24.59: mitochondrial intermediate peptidase
EC 3.4.24.60: dactylysin
EC 3.4.24.61: nardilysin
EC 3.4.24.62: magnolysin
EC 3.4.24.63: meprin B
EC 3.4.24.64: mitochondrial processing peptidase
EC 3.4.24.65: macrophage elastase
EC 3.4.24.66: choriolysin L
EC 3.4.24.67: choriolysin H
EC 3.4.24.68: tentoxilysin
EC 3.4.24.69: bontoxilysin
EC 3.4.24.70: oligopeptidase A
EC 3.4.24.71: endothelin-converting enzyme 1
EC 3.4.24.72: fibrolase
EC 3.4.24.73: jararhagin
EC 3.4.24.74: fragilysin
EC 3.4.24.75: lysostaphin
EC 3.4.24.76: flavastacin
EC 3.4.24.77: snapalysin
EC 3.4.24.78: gpr endopeptidase
EC 3.4.24.79: pappalysin-1
EC 3.4.24.80: membrane-type matrix metalloproteinase-1
EC 3.4.24.81: ADAM10 endopeptidase
EC 3.4.24.82: ADAMTS-4 endopeptidase
EC 3.4.24.83: anthrax lethal factor endopeptidase
EC 3.4.24.84: Ste24 endopeptidase
EC 3.4.24.85: S2P endopeptidase
EC 3.4.24.86: ADAM 17 endopeptidase
EC 3.4.24.87: ADAMTS13 endopeptidase

EC 3.4.25 Threonine endopeptidases[edit]

EC 3.4.99.7: Deleted entry: euphorbain
EC 3.4.99.8: Deleted entry: Gliocladium proteinase
EC 3.4.99.9: Deleted entry: hurain. Now considered to be EC 3.4.21.25, cucumisin
EC 3.4.99.10: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
EC 3.4.99.11: Deleted entry: Streptomyces alkalophilic keratinase
EC 3.4.99.12: Deleted entry: Trichophyton mentagrophytes keratinase
EC 3.4.99.13: Transferred entry: β-lytic proteinase (Mycobacterium sorangium). Now EC 3.4.24.32 EC 3.4.24.32, β-lytic metalloendopeptidase
EC 3.4.99.14: Deleted entry: mexicanain
EC 3.4.99.15: Deleted entry: Paecilomyces proteinase
EC 3.4.99.16: Deleted entry: Penicillium notatum extracellular proteinase
EC 3.4.99.17: Deleted entry: peptidoglycan endopeptidase
EC 3.4.99.18: Deleted entry: pinguinain
EC 3.4.99.19: Transferred entry: renin. Now EC 3.4.23.15, renin
EC 3.4.99.20: Deleted entry: scopulariopsis proteinase
EC 3.4.99.21: Deleted entry: solanain. Now considered EC 3.4.21.25, cucumisin
EC 3.4.99.22: Transferred entry: staphylokinase. EC 3.4.24.29, aureolysin
EC 3.4.99.23: Deleted entry: tabernamontanain. Now considered EC 3.4.21.25, cucumisin
EC 3.4.99.24: Deleted entry: Tenebrio α-proteinase
EC 3.4.99.25: Transferred entry: trametes acid proteinase. EC 3.4.23.21, rhizopuspepsin
EC 3.4.99.26: Transferred entry: urokinase. Now EC 3.4.21.68, t-plasminogen activator
EC 3.4.99.27: Deleted entry: Echis carinatus prothrombin-activating proteinase
EC 3.4.99.28: Transferred entry: Oxyuranus scutellatus prothrombin-activating proteinase. EC 3.4.21.60 EC 3.4.21.60, scutelarin
EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I
EC 3.4.99.30: Transferred entry: Myxobacter AL-1 proteinase II. EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
EC 3.4.99.31: Transferred entry: tissue endopeptidase degrading collagenase synthetic substrate. EC 3.4.24.15, thimet oligopeptidase
EC 3.4.99.32: Transferred entry: Armillaria mellea neutral proteinase. Now EC 3.4.24.20, peptidyl-Lys metalloendopeptidase
EC 3.4.99.33: Deleted entry: cathepsin R
EC 3.4.99.34: Deleted entry: mytilidase
EC 3.4.99.35: Transferred entry: premurein-leader peptidase. Now EC 3.4.23.36, signal peptidase II
EC 3.4.99.36: Transferred entry: leader peptidase. Now EC 3.4.21.89, signal peptidase I
EC 3.4.99.37: Deleted entry: RecA peptidase
EC 3.4.99.38: Transferred entry: pro-opiomelanotropin-converting proteinase. Now EC 3.4.23.17, pro-opiomelanocortin converting enzyme
EC 3.4.99.39: Deleted entry: pseudomurein endopeptidase
EC 3.4.99.40: Deleted entry: pro-gonadoliberin proteinase
EC 3.4.99.41: Transferred entry: mitochondrial processing peptidase. Now EC 3.4.24.64, mitochondrial processing peptidase
EC 3.4.99.42: Deleted entry: leucyllysine endopeptidase
EC 3.4.99.43: Transferred entry: thermopsin. Npw EC 3.4.23.42, thermopsin
EC 3.4.99.44: Transferred entry: pitrilysin. Now EC 3.4.24.55, pitrilysin
EC 3.4.99.45: Transferred entry: insulinase. Now EC 3.4.24.56, insulysin
EC 3.4.99.46: Transferred entry: multicatalytic endopeptidase complex. Now EC 3.4.25.1, proteasome endopeptidase complex

EC 3.5: Acting on carbon-nitrogen bonds, other than peptide bonds[edit]

3.5.1: In linear amides[edit]

EC 3.5.1.1: asparaginase
EC 3.5.1.2: glutaminase
EC 3.5.1.3: ω-amidase
EC 3.5.1.4: amidase
EC 3.5.1.5: urease
EC 3.5.1.6: β-ureidopropionase
EC 3.5.1.7: ureidosuccinase
EC 3.5.1.8: formylaspartate deformylase
EC 3.5.1.9: arylformamidase
EC 3.5.1.10: formyltetrahydrofolate deformylase
EC 3.5.1.11: penicillin amidase
EC 3.5.1.12: biotinidase
EC 3.5.1.13: aryl-acylamidase
EC 3.5.1.14: N-acyl-aliphatic-L-amino acid amidohydrolase
EC 3.5.1.15: aspartoacylase
EC 3.5.1.16: acetylornithine deacetylase
EC 3.5.1.17: acyl-lysine deacylase
EC 3.5.1.18: succinyl-diaminopimelate desuccinylase
EC 3.5.1.19: nicotinamidase
EC 3.5.1.20: citrullinase
EC 3.5.1.21: N-acetyl-β-alanine deacetylas
EC 3.5.1.22: pantothenase
EC 3.5.1.23: ceramidase
EC 3.5.1.24: choloylglycine hydrolase
EC 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase
EC 3.5.1.26: N⁴-(β-N-acetylglucosaminyl)-L-asparaginase
EC 3.5.1.27: The activity is covered by EC 3.5.1.88, peptide deformylase
EC 3.5.1.28: N-acetylmuramoyl-L-alanine amidase
EC 3.5.1.29: 2-(acetamidomethylene)succinate hydrolase
EC 3.5.1.30: 5-aminopentanamidase
EC 3.5.1.31: formylmethionine deformylase
EC 3.5.1.32: hippurate hydrolase
EC 3.5.1.33: N-acetylglucosamine deacetylase
EC 3.5.1.34: Identical with EC 3.4.13.5, Xaa-methyl-His dipeptidase
EC 3.5.1.35: Dglutaminase
EC 3.5.1.36: N-methyl-2-oxoglutaramate hydrolase
EC 3.5.1.37: Delete, identical with EC 3.5.1.26 N⁴-(β-N-acetylglucosaminyl)-L-asparaginase
EC 3.5.1.38: glutamin-(asparagin-)ase
EC 3.5.1.39: alkylamidase
EC 3.5.1.40: acylagmatine amidase
EC 3.5.1.41: chitin deacetylase
EC 3.5.1.42: nicotinamide-nucleotide amidase
EC 3.5.1.43: peptidyl-glutaminase
EC 3.5.1.44: protein-glutamine glutaminase
EC 3.5.1.45: Now listed only as EC 6.3.4.6 urea carboxylase
EC 3.5.1.46: 6-aminohexanoate-dimer hydrolase
EC 3.5.1.47: N-acetyldiaminopimelate deacetylase
EC 3.5.1.48: acetylspermidine deacetylase
EC 3.5.1.49: formamidase
EC 3.5.1.50: pentanamidase
EC 3.5.1.51: 4-acetamidobutyryl-CoA deacetylase
EC 3.5.1.52: peptide-N⁴-(N-acetyl-β-glucosaminyl)asparagine amidase
EC 3.5.1.53: N-carbamoylputrescine amidase
EC 3.5.1.54: allophanate hydrolase
EC 3.5.1.55: long-chain-fatty-acyl-glutamate deacylase
EC 3.5.1.56: N,N-dimethylformamidase
EC 3.5.1.57: tryptophanamidase
EC 3.5.1.58: N-benzyloxycarbonylglycine hydrolase
EC 3.5.1.59: N-carbamoylsarcosine amidase
EC 3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase
EC 3.5.1.61: mimosinase
EC 3.5.1.62: acetylputrescine deacetylase
EC 3.5.1.63: 4-acetamidobutyrate deacetylase
EC 3.5.1.64: N^α-benzyloxycarbonylleucine hydrolase
EC 3.5.1.65: theanine hydrolase
EC 3.5.1.66: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
EC 3.5.1.67: 4-methyleneglutaminase
EC 3.5.1.68: N-formylglutamate deformylase
EC 3.5.1.69: glycosphingolipid deacylase
EC 3.5.1.70: aculeacin-A deacylase
EC 3.5.1.71: N-feruloylglycine deacylase
EC 3.5.1.72: D-benzoylarginine-4-nitroanilide amidase
EC 3.5.1.73: carnitinamidase
EC 3.5.1.74: chenodeoxycholoyltaurine hydrolase
EC 3.5.1.75: urethanase
EC 3.5.1.76: arylalkyl acylamidase
EC 3.5.1.77: N-carbamoyl-D-amino-acid hydrolase
EC 3.5.1.78: glutathionylspermidine amidase
EC 3.5.1.79: phthalyl amidase
EC 3.5.1.80: Identical to EC 3.5.1.25, N-acetylglucosamine-6-phosphate deacetylase
EC 3.5.1.81: N-acylD-amino-acid deacylase
EC 3.5.1.82: N-acyl-D-glutamate deacylase
EC 3.5.1.83: N-acyl-D-aspartate deacylase
EC 3.5.1.84: biuret amidohydrolase
EC 3.5.1.85: (S)-N-acetyl-1-phenylethylamine hydrolase
EC 3.5.1.86: mandelamide amidase
EC 3.5.1.87: N-carbamoyl-L-amino-acid hydrolase
EC 3.5.1.88: peptide deformylase
EC 3.5.1.89: N-acetylglucosaminylphosphatidylinositol deacetylase
EC 3.5.1.90: adenosylcobinamide hydrolase
EC 3.5.1.91: N-substituted formamide deformylase
EC 3.5.1.92: pantetheine hydrolase
EC 3.5.1.93: glutaryl-7-aminocephalosporanic-acid acylase
EC 3.5.1.94: γ-glutamyl-γ-aminobutyrate hydrolase
EC 3.5.1.95: N-malonylurea hydrolase
EC 3.5.1.96: succinylglutamate desuccinylase
EC 3.5.1.97: acyl-homoserine-lactone acylase
EC 3.5.1.98: histone deacetylase
EC 3.5.1.99: fatty acid amide hydrolase
EC 3.5.1.100: (R)-amidase
EC 3.5.1.101: L-proline amide hydrolase
EC 3.5.1.102: 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5′-monophosphate deformylase
EC 3.5.1.103: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase
EC 3.5.1.104: peptidoglycan-N-acetylglucosamine deacetylase
EC 3.5.1.105: chitin disaccharide deacetylase
EC 3.5.1.106: N-formylmaleamate deformylase
EC 3.5.1.107: maleamate amidohydrolase
EC 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase
EC 3.5.1.109: sphingomyelin deacylase
EC 3.5.1.110: ureidoacrylate amidohydrolase
EC 3.5.1.111: 2-oxoglutaramate amidase
EC 3.5.1.112: 2′-N-acetylparomamine deacetylase
EC 3.5.1.113: 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase
EC 3.5.1.114: N-acyl-aromatic-L-amino acid amidohydrolase *
EC 3.5.1.115: mycothiol S-conjugate amidase *
EC 3.5.1.116: ureidoglycolate amidohydrolase *
EC 3.5.1.117: 6-aminohexanoate-oligomer endohydrolase *
EC 3.5.1.118: γ-glutamyl hercynylcysteine S-oxide hydrolase *
EC 3.5.1.119: Pup amidohydrolase *
EC 3.5.1.120: Now EC 3.5.99.11, 2-aminomuconate deaminase (2-hydroxymuconate-forming)
EC 3.5.1.121: protein N-terminal asparagine amidohydrolase *
EC 3.5.1.122: protein N-terminal glutamine amidohydrolase *
EC 3.5.1.123: γ-glutamylanilide hydrolase *
EC 3.5.1.124: protein deglycase *
EC 3.5.1.125: N²-acetyl-L-2,4-diaminobutanoate deacetylase *
EC 3.5.1.126: oxamate amidohydrolase *
EC 3.5.1.127: jasmonoyl-L-amino acid hydrolase *
EC 3.5.1.128: deaminated glutathione amidase *
EC 3.5.1.129: N⁵-(cytidine 5′-diphosphoramidyl)-L-glutamine hydrolase *
EC 3.5.1.130: [amino group carrier protein]-lysine hydrolase *
EC 3.5.1.131: 1-carboxybiuret hydrolase *
EC 3.5.1.132: [amino group carrier protein]-ornithine hydrolase *
EC 3.5.1.133: N^α-acyl-L-glutamine aminoacylase *
EC 3.5.1.134: (indol-3-yl)acetyl-L-aspartate hydrolase *
EC 3.5.1.135: N⁴-acetylcytidine amidohydrolase *
EC 3.5.1.136: N,N′-diacetylchitobiose non-reducing end deacetylase *

*No Wikipedia article

3.5.2: In cyclic amides[edit]

EC 3.5.2.1: barbiturase
EC 3.5.2.2: dihydropyrimidinase
EC 3.5.2.3: dihydroorotase
EC 3.5.2.4: carboxymethylhydantoinase
EC 3.5.2.5: allantoinase
EC 3.5.2.6: β-lactamase
EC 3.5.2.7: imidazolonepropionase
EC 3.5.2.8: Now included with EC 3.5.2.6, β-lactamase
EC 3.5.2.9: 5-oxoprolinase (ATP-hydrolysing)
EC 3.5.2.10: creatininase
EC 3.5.2.11: L-lysine-lactamase
EC 3.5.2.12: 6-aminohexanoate-cyclic-dimer hydrolase
EC 3.5.2.13: 2,5-dioxopiperazine hydrolase
EC 3.5.2.14: N-methylhydantoinase (ATP-hydrolysing)
EC 3.5.2.15: cyanuric acid amidohydrolase
EC 3.5.2.16: maleimide hydrolase
EC 3.5.2.17: hydroxyisourate hydrolase
EC 3.5.2.18: enamidase
EC 3.5.2.19: streptothricin hydrolase
EC 3.5.2.20: isatin hydrolase *

*No Wikipedia article

3.5.3: In linear amidines[edit]

EC 3.5.3.1: arginase
EC 3.5.3.2: guanidinoacetase
EC 3.5.3.3: creatinase
EC 3.5.3.4: allantoicase
EC 3.5.3.5: formimidoylaspartate deiminase
EC 3.5.3.6: arginine deiminase
EC 3.5.3.7: guanidinobutyrase
EC 3.5.3.8: formimidoylglutamase
EC 3.5.3.9: allantoate deiminase
EC 3.5.3.10: D-arginase
EC 3.5.3.11: agmatinase
EC 3.5.3.12: agmatine deiminase
EC 3.5.3.13: formimidoylglutamate deiminase
EC 3.5.3.14: amidinoaspartase
EC 3.5.3.15: protein-arginine deiminase
EC 3.5.3.16: methylguanidinase
EC 3.5.3.17: guanidinopropionase
EC 3.5.3.18: dimethylargininase
EC 3.5.3.19: Now EC 3.5.1.116, ureidoglycolate amidohydrolase
EC 3.5.3.20: diguanidinobutanase
EC 3.5.3.21: Methylenediurea deaminase
EC 3.5.3.22: proclavaminate amidinohydrolase
EC 3.5.3.23: N-succinylarginine dihydrolase
EC 3.5.3.24: N¹-aminopropylagmatine ureohydrolase *
EC 3.5.3.25: N^ω-hydroxy-L-arginine amidinohydrolase *
EC 3.5.3.26: (S)-ureidoglycine aminohydrolase *

*No Wikipedia article

3.5.4: In cyclic amidines[edit]

EC 3.5.4.1: cytosine deaminase
EC 3.5.4.2: adenine deaminase
EC 3.5.4.3: guanine deaminase
EC 3.5.4.4: adenosine deaminase
EC 3.5.4.5: cytidine deaminase
EC 3.5.4.6: AMP deaminase
EC 3.5.4.7: ADP deaminase
EC 3.5.4.8: aminoimidazolase
EC 3.5.4.9: methenyltetrahydrofolate cyclohydrolase
EC 3.5.4.10: IMP cyclohydrolase
EC 3.5.4.11: pterin deaminase
EC 3.5.4.12: dCMP deaminase
EC 3.5.4.13: dCTP deaminase
EC 3.5.4.14: Now included in EC 3.5.4.5, (deoxy)cytidine deaminase
EC 3.5.4.15: guanosine deaminase
EC 3.5.4.16: GTP cyclohydrolase I
EC 3.5.4.17: adenosine-phosphate deaminase
EC 3.5.4.18: ATP deaminase
EC 3.5.4.19: phosphoribosyl-AMP cyclohydrolase
EC 3.5.4.20: pyrithiamine deaminase
EC 3.5.4.21: creatinine deaminase
EC 3.5.4.22: 1-pyrroline-4-hydroxy-2-carboxylate deaminase
EC 3.5.4.23: blasticidin-S deaminase
EC 3.5.4.24: sepiapterin deaminase
EC 3.5.4.25: GTP cyclohydrolase II
EC 3.5.4.26: diaminohydroxyphosphoribosylaminopyrimidine deaminase
EC 3.5.4.27: methenyltetrahydromethanopterin cyclohydrolase
EC 3.5.4.28: S-adenosylhomocysteine deaminase
EC 3.5.4.29: GTP cyclohydrolase IIa
EC 3.5.4.30: dCTP deaminase (dUMP-forming)
EC 3.5.4.31: S-methyl-5′-thioadenosine deaminase
EC 3.5.4.32: 8-oxoguanine deaminase
EC 3.5.4.33: tRNA(adenine³⁴) deaminase *
EC 3.5.4.34: tRNA^Ala(adenine³⁷) deaminase *
EC 3.5.4.35: tRNA(cytosine⁸) deaminase *
EC 3.5.4.36: mRNA(cytosine⁶⁶⁶⁶) deaminase *
EC 3.5.4.37: double-stranded RNA adenine deaminase *
EC 3.5.4.38: single-stranded DNA cytosine deaminase *
EC 3.5.4.39: GTP cyclohydrolase IV *
EC 3.5.4.40: aminodeoxyfutalosine deaminase *
EC 3.5.4.41: 5'-deoxyadenosine deaminase
EC 3.5.4.42: N-isopropylammelide isopropylaminohydrolase *
EC 3.5.4.43: hydroxydechloroatrazine ethylaminohydrolase *
EC 3.5.4.44: ectoine hydrolase *
EC 3.5.4.45: melamine deaminase *
EC 3.5.4.46: cAMP deaminase *

*No Wikipedia article

3.5.5: In nitriles[edit]

EC 3.5.5.1: nitrilase
EC 3.5.5.2: ricinine nitrilase
EC 3.5.5.3: Now EC 4.2.1.104, cyanate hydratase
EC 3.5.5.4: cyanoalanine nitrilase
EC 3.5.5.5: arylacetonitrilase
EC 3.5.5.6: bromoxynil nitrilase
EC 3.5.5.7: aliphatic nitrilase
EC 3.5.5.8: thiocyanate hydrolase

3.5.99: In other compounds[edit]

EC 3.5.99.1: riboflavinase
EC 3.5.99.2: aminopyrimidine aminohydrolase
EC 3.5.99.3: Now EC 3.5.4.43, hydroxydechloroatrazine ethylaminohydrolase
EC 3.5.99.4: Now EC 3.5.4.42, N-isopropylammelide isopropylaminohydrolase
EC 3.5.99.5: 2-aminomuconate deaminase
EC 3.5.99.6: glucosamine-6-phosphate deaminase
EC 3.5.99.7: 1-aminocyclopropane-1-carboxylate deaminase
EC 3.5.99.8: 5-nitroanthranilic acid aminohydrolase
EC 3.5.99.9: 2-nitroimidazole nitrohydrolase
EC 3.5.99.10: 2-iminobutanoate/2-iminopropanoate deaminase *
EC 3.5.99.11: 2-aminomuconate deaminase (2-hydroxymuconate-forming) *

*No Wikipedia article

EC 3.6: Acting on acid anhydrides[edit]

3.6.1: In phosphorus-containing anhydrides[edit]

EC 3.6.1.1: inorganic diphosphatase
EC 3.6.1.2: trimetaphosphatase
EC 3.6.1.3: adenosinetriphosphatase
EC 3.6.1.4: Now included with EC 3.6.1.3, adenosinetriphosphatase
EC 3.6.1.5: apyrase
EC 3.6.1.6: nucleoside diphosphate phosphatase
EC 3.6.1.7: acylphosphatase
EC 3.6.1.8: ATP diphosphatase
EC 3.6.1.9: nucleotide diphosphatase
EC 3.6.1.10: endopolyphosphatase
EC 3.6.1.11: exopolyphosphatase
EC 3.6.1.12: dCTP diphosphatase
EC 3.6.1.13: ADP-ribose diphosphatase
EC 3.6.1.14: adenosine-tetraphosphatase
EC 3.6.1.15: nucleoside-triphosphatase
EC 3.6.1.16: CDP-glycerol diphosphatase
EC 3.6.1.17: bis(5′-nucleosyl)-tetraphosphatase (asymmetrical))
EC 3.6.1.18: FAD diphosphatase
EC 3.6.1.19: Now EC 3.6.1.9, nucleotide diphosphatase
EC 3.6.1.20: 5′-acylphosphoadenosine hydrolase
EC 3.6.1.21: ADP-sugar diphosphatase
EC 3.6.1.22: NAD⁺ diphosphatase
EC 3.6.1.23: dUTP diphosphatase
EC 3.6.1.24: nucleoside phosphoacylhydrolase
EC 3.6.1.25: triphosphatase
EC 3.6.1.26: CDP-diacylglycerol diphosphatase
EC 3.6.1.27: undecaprenyl-diphosphatase
EC 3.6.1.28: thiamine-triphosphatase
EC 3.6.1.29: bis(5′-adenosyl)-triphosphatase
EC 3.6.1.30: Now covered by EC 3.6.1.59 [m⁷GpppX diphosphatase] and EC 3.6.1.62 [m⁷GpppN-mRNA hydrolase].
EC 3.6.1.31: phosphoribosyl-ATP diphosphatase
EC 3.6.1.32: Now EC 3.6.4.1, myosin ATPase
EC 3.6.1.33: Now EC 3.6.4.2, dynein ATPase
EC 3.6.1.34: Transferred entry: H⁺-transporting ATP synthase. Now EC 3.6.3.14, H⁺-transporting two-sector ATPase
EC 3.6.1.35: Now EC 3.6.3.6, H⁺-exporting ATPase
EC 3.6.1.36: Now EC 3.6.3.10, H⁺/K⁺-exchanging ATPase
EC 3.6.1.37: Now EC 3.6.3.9, Na⁺/K⁺-exchanging ATPase
EC 3.6.1.38: Now EC 3.6.3.8, Ca²⁺-transporting ATPase
EC 3.6.1.39: thymidine-triphosphatase
EC 3.6.1.40: guanosine-5′-triphosphate,3′-diphosphate phosphatase
EC 3.6.1.41: bis(5′-nucleosyl)-tetraphosphatase (symmetrical)
EC 3.6.1.42: guanosine-diphosphatase
EC 3.6.1.43: dolichyldiphosphatase
EC 3.6.1.44: oligosaccharide-diphosphodolichol diphosphatase
EC 3.6.1.45: UDP-sugar diphosphatase
EC 3.6.1.46: Now EC 3.6.5.1, heterotrimeric G-protein GTPase
EC 3.6.1.47: Now EC 3.6.5.3, protein-synthesizing GTPase
EC 3.6.1.49: Now EC 3.6.5.4, signal-recognition-particle GTPase
EC 3.6.1.50: Now EC 3.6.5.5, dynamin GTPase
EC 3.6.1.51: Now EC 3.6.5.6, tubulin GTPase
EC 3.6.1.52: diphosphoinositol-polyphosphate diphosphatase
EC 3.6.1.53: Mn²⁺-dependent ADP-ribose/CDP-alcohol diphosphatase
EC 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase
EC 3.6.1.55: 8-oxo-dGTP diphosphatase
EC 3.6.1.56: 2-hydroxy-dATP diphosphatase
EC 3.6.1.57: UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
EC 3.6.1.58: 8-oxo-dGDP phosphatase
EC 3.6.1.59: 5′-(N⁷-methyl 5′-triphosphoguanosine)-[mRNA] diphosphatase
EC 3.6.1.60: diadenosine hexaphosphate hydrolase (AMP-forming)
EC 3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming)
EC 3.6.1.62: 5′-(N⁷-methylguanosine 5′-triphospho)-[mRNA] hydrolase
EC 3.6.1.63: α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
EC 3.6.1.64: inosine diphosphate phosphatase *
EC 3.6.1.65: (d)CTP diphosphatase *
EC 3.6.1.66: XTP/dITP diphosphatase *
EC 3.6.1.67: dihydroneopterin triphosphate diphosphatase *
EC 3.6.1.68: geranyl diphosphate phosphohydrolase *
EC 3.6.1.69: 8-oxo-(d)GTP phosphatase *
EC 3.6.1.70: guanosine-5′-diphospho-5′-[DNA] diphosphatase *
EC 3.6.1.71: adenosine-5′-diphospho-5′-[DNA] diphosphatase *
EC 3.6.1.72: DNA-3′-diphospho-5′-guanosine diphosphatase *
EC 3.6.1.73: inosine/xanthosine triphosphatase *
EC 3.6.1.74: mRNA 5′-phosphatase *

*No Wikipedia article

3.6.2: In sulfonyl-containing anhydrides[edit]

3.6.3: Acting on acid anhydrides to catalyse transmembrane movement of substances[edit]

EC 3.6.3.1: phospholipid-translocating ATPase
EC 3.6.3.2: Now EC 7.2.2.14, P-type Mg²⁺ transporter
EC 3.6.3.3: Now EC 7.2.2.21, Cd²⁺-exporting ATPase
EC 3.6.3.4: Now EC 7.2.2.9, Cu²⁺-exporting ATPase
EC 3.6.3.5: Now EC 7.2.2.12, Zn²⁺-exporting ATPase
EC 3.6.3.6: Now EC 7.1.2.1, P-type H⁺-exporting transporter
EC 3.6.3.7: Now EC 7.2.2.3, P-type Na⁺ transporter
EC 3.6.3.8: Now EC 7.2.2.10, Ca²⁺-transporting ATPase
EC 3.6.3.9: Now EC 7.2.2.13, Na⁺/K⁺-exchanging ATPase
EC 3.6.3.10: Now EC 7.2.2.19, H⁺/K⁺-exchanging ATPase
EC 3.6.3.11: Cl^–-transporting ATPase. The activity was only ever studied in crude extracts}}, and is an artifact
EC 3.6.3.12: Now EC 7.2.2.6, K⁺-transporting ATPase
EC 3.6.3.13:Identical to EC 3.6.3.1, phospholipid-translocating ATPase
EC 3.6.3.14: Now EC 7.1.2.2, H⁺-transporting two-sector ATPase
EC 3.6.3.15: Now EC 7.2.2.1, Na⁺-transporting two-sector ATPase
EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase
EC 3.6.3.17: Now covered by various ABC-type monosaccharide transporters in sub-subclass EC 7.5.2
EC 3.6.3.18: Now EC 7.5.2.2, ABC-type oligosaccharide transporter
EC 3.6.3.19: Now EC 7.5.2.1, ABC-type maltose transporter
EC 3.6.3.20: Now EC 7.6.2.10, glycerol-3-phosphate-transporting ATPase
EC 3.6.3.21: Now EC 7.4.2.1, ABC-type polar-amino-acid transporter
EC 3.6.3.22: Now EC 7.4.2.2, ABC-type nonpolar-amino-acid transporter
EC 3.6.3.23: Now EC 7.4.2.6, oligopeptide-transporting ATPase
EC 3.6.3.24: Now EC 7.2.2.11, nickel-transporting ATPase
EC 3.6.3.25: Now EC 7.3.2.3, sulfate-transporting ATPase
EC 3.6.3.26: Now EC 7.3.2.4, nitrate-transporting ATPase
EC 3.6.3.27: Now EC 7.3.2.1, ABC-type phosphate transporter
EC 3.6.3.28: Now EC 7.3.2.2, ABC-type phosphonate transporter
EC 3.6.3.29: Now EC 7.3.2.5, molybdate-transporting ATPase
EC 3.6.3.30: Now EC 7.2.2.7, Fe³⁺-transporting ATPase
EC 3.6.3.31: Now EC 7.6.2.11, polyamine-transporting ATPase
EC 3.6.3.32: Now EC 7.6.2.9, quaternary-amine-transporting ATPase
EC 3.6.3.33: Now EC 7.6.2.8, vitamin B₁₂-transporting ATPase
EC 3.6.3.34: now recognized to be at least three separate enzymes EC 7.2.2.16, iron(III) hydroxamate ABC transporter, EC 7.2.2.17, ferric enterobactin ABC transporter, and EC 7.2.2.18, ferric citrate ABC transporter
EC 3.6.3.35: Now EC 7.2.2.5, manganese-transporting ATPase
EC 3.6.3.36: Now EC 7.6.2.7, taurine-transporting ATPase
EC 3.6.3.37: Now EC 7.6.2.6, guanine-transporting ATPase
EC 3.6.3.38: Now EC 7.6.2.12, ABC-type capsular-polysaccharide transporter
EC 3.6.3.39: Now EC 7.5.2.5, lipopolysaccharide-transporting ATPase
EC 3.6.3.40: Now EC 7.5.2.4, teichoic-acid-transporting ATPase
EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase
EC 3.6.3.42: Now EC 7.5.2.3, β-glucan-transporting ATPase
EC 3.6.3.43: Now EC 7.4.2.5, peptide-transporting ATPase
EC 3.6.3.44: Now EC 7.6.2.2, ABC-type xenobiotic transporter
EC 3.6.3.45: Now included with EC 3.6.3.44, xenobiotic-transporting ATPase
EC 3.6.3.46: Now EC 7.2.2.2, ABC-type Cd²⁺ transporter
EC 3.6.3.47: Now EC 7.6.2.4, fatty-acyl-CoA-transporting ATPase
EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase
EC 3.6.3.49: Now EC 5.6.1.6, channel-conductance-controlling ATPase
EC 3.6.3.50: Now EC 7.4.2.8, protein-secreting ATPase
EC 3.6.3.51: Now EC 7.4.2.3, mitochondrial protein-transporting ATPase
EC 3.6.3.52: Now EC 7.4.2.4, chloroplast protein-transporting ATPase
EC 3.6.3.53: Now EC 7.2.2.15, Ag⁺-exporting ATPase
EC 3.6.3.54: Now EC 7.2.2.8, Cu⁺-exporting ATPase
EC 3.6.3.55: Now EC 7.3.2.6, tungstate-importing ATPase

3.6.4: Acting on acid anhydrides to facilitate cellular and subcellular movement[edit]

EC 3.6.4.1: Now EC 5.6.1.8, myosin ATPase
EC 3.6.4.2: Now EC 5.6.1.2, dynein ATPase
EC 3.6.4.3: Now EC 5.6.1.1, microtubule-severing ATPase
EC 3.6.4.4: Now EC 5.6.1.3, plus-end-directed kinesin ATPase
EC 3.6.4.5: Now EC 5.6.1.4, minus-end-directed kinesin ATPase
EC 3.6.4.6: vesicle-fusing ATPase
EC 3.6.4.7: peroxisome-assembly ATPase
EC 3.6.4.8: Now EC 5.6.1.5, proteasome ATPase
EC 3.6.4.9: Now EC 5.6.1.7, chaperonin ATPase
EC 3.6.4.10: non-chaperonin molecular chaperone ATPase
EC 3.6.4.11: Deleted, the activity has been shown not to take place
EC 3.6.4.12: DNA helicase
EC 3.6.4.13: RNA helicase

3.6.5: Acting on GTP to facilitate cellular and subcellular movement[edit]

EC 3.7: Acting on carbon-carbon bonds[edit]

EC 3.7.1: In ketonic substances[edit]

EC 3.7.1.1: oxaloacetase
EC 3.7.1.2: fumarylacetoacetase
EC 3.7.1.3: kynureninase
EC 3.7.1.4: phloretin hydrolase
EC 3.7.1.5: acylpyruvate hydrolase
EC 3.7.1.6: acetylpyruvate hydrolase
EC 3.7.1.7: β-diketone hydrolase
EC 3.7.1.8: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
EC 3.7.1.9: 2-hydroxymuconate-semialdehyde hydrolase
EC 3.7.1.10: cyclohexane-1,3-dione hydrolase
EC 3.7.1.11: cyclohexane-1,2-dione hydrolase
EC 3.7.1.12: cobalt-precorrin 5A hydrolase
EC 3.7.1.13: 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
EC 3.7.1.14: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
EC 3.7.1.15: Now EC 4.2.1.138, (+)-caryolan-1-ol synthase
EC 3.7.1.16: Now EC 3.3.2.12, oxepin-CoA hydrolase
EC 3.7.1.17: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
EC 3.7.1.18: 6-oxocamphor hydrolase
EC 3.7.1.19: 2,6-dihydroxypseudooxynicotine hydrolase
EC 3.7.1.20: 3-fumarylpyruvate hydrolase
EC 3.7.1.21: 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase *
EC 3.7.1.22: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening)
EC 3.7.1.23: maleylpyruvate hydrolase *
EC 3.7.1.24: 2,4-diacetylphloroglucinol hydrolase *
EC 3.7.1.25: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase *
EC 3.7.1.26: 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase *
EC 3.7.1.27: neryl diphosphate diphosphatase *
EC 3.7.1.28: 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase *

*No Wikipedia article

EC 3.8: Acting on halide bonds[edit]

EC 3.8.1: Acting on halide bonds[edit]

EC 3.8.1.1: Covered by EC 3.8.1.5, haloalkane dehalogenase.
EC 3.8.1.2: (S)-2-haloacid dehalogenase
EC 3.8.1.3: haloacetate dehalogenase
EC 3.8.1.4: Now EC 1.97.1.10, thyroxine 5′-deiodinase
EC 3.8.1.5: haloalkane dehalogenase
EC 3.8.1.6: 4-chlorobenzoate dehalogenase
EC 3.8.1.7: 4-chlorobenzoyl-CoA dehalogenase
EC 3.8.1.8: atrazine chlorohydrolase
EC 3.8.1.9: (R)-2-haloacid dehalogenase
EC 3.8.1.10: 2-haloacid dehalogenase (configuration-inverting)
EC 3.8.1.11: 2-haloacid dehalogenase (configuration-retaining)

3.8.2: In phosphorus-halide compounds (deleted sub-subclass)[edit]

EC 3.8.2.1: Now EC 3.1.8.2, diisopropyl-fluorophosphatase

EC 3.9: act on phosphorus-nitrogen bonds[edit]

EC 3.9.1: Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date)[edit]

EC 3.9.1.1: phosphoamidase
EC 3.9.1.2: protein arginine phosphatase *
EC 3.9.1.3: phosphohistidine phosphatase *

*No Wikipedia article

EC 3.10: Acting on sulfur-nitrogen bonds[edit]

EC 3.10.1: Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)[edit]

EC 3.11: Acting on carbon-phosphorus bonds[edit]

EC 3.11.1: Acting on carbon-phosphorus bonds (only sub-subclass identified to date)[edit]

EC 3.12: Acting on sulfur-sulfur bonds[edit]

EC 3.12.1: Acting on sulfur-sulfur bonds (only sub-subclass identified to date)[edit]

EC 3.12.1.1: trithionate hydrolase

EC 3.13: Acting on carbon-sulfur bonds[edit]

EC 3.13.1: Acting on carbon-sulfur bonds (only sub-subclass identified to date)[edit]

EC 3.13.1.1: UDP-sulfoquinovose synthase
EC 3.13.1.2: Deleted, the activity is most probably attributable to EC 4.4.1.21, S-ribosylhomocysteine lyase
EC 3.13.1.3: 2′-hydroxybiphenyl-2-sulfinate desulfinase
EC 3.13.1.4: 3-sulfinopropanoyl-CoA desulfinase *
EC 3.13.1.5: carbon disulfide hydrolase
EC 3.13.1.6: [CysO sulfur-carrier protein]-S-L-cysteine hydrolase *
EC 3.13.1.7: Carbonyl sulfide hydrolase
EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming *
EC 3.13.1.9: S-inosyl-L-homocysteine hydrolase *

*No Wikipedia article

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

t

e

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4:
Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)

3.1.11-16:
Exonuclease

Exodeoxyribonuclease

RecBCD

Exoribonuclease

Oligonucleotidase

3.1.21-31:
Endonuclease

Endodeoxyribonuclease

Endoribonuclease

RNase III
- Drosha: Microprocessor complex
- Dicer: RNA-induced silencing complex
RNase H
- 1
- 2A
- 2B
- 2C
RNase P
RNase A
RNase Z
RNase E
- 1
- 2
- 3
- 4/5
RNase T1

either deoxy- or ribo-

t

e

Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases

Other

3.2.2: Hydrolysing
N-Glycosyl compounds

DNA glycosylases: Oxoguanine glycosylase

t

e

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases: Cathepsin A DD-transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

v t e Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aminoacylase ACY1 Aspartoacylase(ACY2) ACY3 Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin
3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase Dihydroorotase
3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase
3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase
3.5.5: Nitriles/ Aminohydrolases	Nitrilase
3.5.99: Other	Riboflavinase Thiaminase II

t

e

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B
Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2
Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4
H+/K+ (3.6.3.10)	ATP4A
Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5.1: Heterotrimeric G protein	G_αs G_olf G_αi GNAI1 GNAI2 GNAI3 Transducin GNAT1 GNAT2 Gustducin GNAT3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13
3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK
3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic
3.6.5.5-6: Polymerization motors	dynamin superfamily Dynamin Guanylate-binding protein Mitofusin-1 MX1 and MX2 OPA1 Tubulin

References[edit]

^ "ExplorEnz – The Enzyme Database".

^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593–D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.

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