Mikuriya was born at his Aunt Mary Schwenk Wallace's home in Brownsville, Pennsylvania,[6] from German teacher Anna Schwenk and civil engineer Tadafumi Mikuriya, an Issei descendant of the Japanese samurai nobility.[7]
Growing up in the Quaker community of Fallsington, Pennsylvania and attending Quaker schools (George School, Haverford College) it was the compromise chosen by his parents that the three Mikuriya children were raised as Quakers. "The Quakers were proprietors of the Underground Railway, I’m proud to say. The cannabis prohibition has the same dynamics as the bigotry and racism my family and I experienced starting on 7 December 1941, when we were transformed from normal-but-different people into war-criminal surrogates."[8] In a 1998 interview, Mikuriya (whose father was a converted Christian and whose mother a follower of the Baháʼí Faith), made a connection between his family background and his views in relation to cannabis.[citation needed] Mikuriya claimed he first heard of cannabis in a children's book in 1959.[9]
Mikuriya first directed a center for the treatment of drug addiction in Princeton, New Jersey (1966–1967) before being appointed director of non-classified marijuana research for the National Institute of Mental Health Center for Narcotics and Drug Abuse Studies in 1967.[11]
In the late 1960s and early 1970s, he authored a number of academic publications creating the debate on the therapeutic use of cannabis within the medical community,[12][13][14] including proposing cannabis as a substitution agent[15] as well as on issues related to the legality of cannabis.[16][17]
His 1972 self-published book Marijuana Medical Papers 1839–1972 became a landmark in the modern movement for the legalization of Medical marijuana. Collected from the reference section at the National Library of Medicine it was saved from complete oblivion.[7] Much to the irritation of cannabis prohibitionists, this medical intelligence has been restored for possible alternative medical applications. Mikuriya continued publicating in the 1970s and 1980s.[18][19][20]
Until his death in May 2007, he continued in private psychiatric practice limited to cannabis clinical consultation. He approved marijuana for medical purposes in over nine thousand patients, not solely in terminal cases, but also alleviation of physical and emotional pain in non-terminal cases. The legal situation is extremely complex (see legal history of marijuana in the United States).
His practices are controversial and have drawn him into conflict with authorities. He was on five years probation with the Medical Board of California resulting from prosecutorial manipulation and conspiracy with local, state, and federal law enforcement vendetta starting in 2000. No patients were harmed. There were no complaints from patients, families or community physicians. Only law enforcement in eleven rural northern California counties responded to solicitation by Medical Board investigators and officials in the California Attorney General's office.[21]
Mikuriya vas involved early on in political and civil movements focused on changing cannabis laws.[7] In 1971, Mikuriya joined the group Amorphia, "a special interest group that was spearheading the California Marijuana Initiative."[3] He took part in the redaction of the failed California Prop. 19 in 1972, and helped Dennis Peron redact San Francisco's Prop P which passed in 1991.
He is maybe more known for his involvement on 1996 California Proposition 215. He declared: "As one of the authors of the Prop 215, my claim to fame is getting the phrase ‘for any other condition that Cannabis is helpful’ included."[3]