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| Names | |||
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| IUPAC name
(SP-4-1)-diamminedichloridoplatinum(II) | |||
| Other names
Reiset's second chloride, transplatin | |||
| Identifiers | |||
3D model (JSmol) |
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| ECHA InfoCard | 100.035.422 
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PubChem CID |
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| UNII | |||
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| Properties | |||
| Cl2H6N2Pt | |||
| Molar mass | 300.05 g·mol−1 | ||
| Appearance | yellow solid | ||
| low | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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trans-Dichlorodiammineplatinum(II) is the trans isomer of the coordination complex with the formula trans-PtCl2(NH3)2, sometimes called transplatin.[1] It is a yellow solid with low solubility in water but good solubility in DMF. The existence of two isomers of PtCl2(NH3)2 led Alfred Werner to propose square planar molecular geometry.[2] It belongs to the molecular symmetry point group D2h.
The complex is prepared by treating [Pt(NH3)4]Cl2 with hydrochloric acid.[2]
Many of the reactions of this complex can be explained by the trans effect. It slowly hydrolyzes in aqueous solution to give the mixed aquo complex trans-[PtCl(H2O)(NH3)2]Cl. Similarly it reacts with thiourea (tu) to give colorless trans-[Pt(tu)2(NH3)2]Cl2. In contrast, the cis isomer gives [Pt(tu)4]Cl2. Oxidative addition of chlorine gives trans-PtCl4(NH3)2.
trans-Dichlorodiammineplatinum(II) has had far less impact on medicinal chemistry compared to its cis isomer, cisplatin, which is a major anticancer drug. Nonetheless, replacement of the ammonia with other ligands has led to highly active drugs that have attracted much attention.[3]
