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1 References  













Tribendimidine






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From Wikipedia, the free encyclopedia
  

Tribendimidine
Clinical data
ATC code
  • none
Identifiers

  • N,N-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4
    -phenylene dimethylidyneamine

CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H32N6
Molar mass452.606 g·mol−1
3D model (JSmol)

  • N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3

  • InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+ checkY

  • Key:XOIOGKHKNQYULW-HTNNXBMUSA-N checkY

 ☒NcheckY (what is this?)  (verify)

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic DiseasesinShanghai. It is a derivative of amidantel.[1]

Inclinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] It is also effective against clonorchiasis.[3] However, animal studies suggest it is ineffective in treating Schistosoma mansoniorFasciola hepatica disease.[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.[4]

Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company LimitedinZibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.[citation needed]

References[edit]

  1. ^ a b Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J (March 2007). "Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini". Antimicrobial Agents and Chemotherapy. 51 (3): 1096–1098. doi:10.1128/AAC.01366-06. PMC 1803157. PMID 17194822. Free full text.
  • ^ Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (April 2005). "Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China". Acta Tropica. 94 (1): 1–14. doi:10.1016/j.actatropica.2005.01.013. PMID 15777691.
  • ^ Zhang H, Liu C, Zheng Q (December 2019). "Development and application of anthelminthic drugs in China". Acta Tropica. 200: 105181. doi:10.1016/j.actatropica.2019.105181. PMID 31542370.
  • ^ Kelland K (2010-11-24). "New drug shows promise against Asian liver fluke". Reuters.
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    This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Tribendimidine&oldid=1169452622"
    Categories: 
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     ●Anthelmintics
     ●Amidines
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    ●This page was last edited on 9 August 2023, at 04:46 (UTC).
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