t
e
|
---|
5-HT1 |
5-HT1A |
-
Agonists: 8-OH-DPAT
-
Adatanserin
-
Amphetamine
-
Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)
-
Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)
-
Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
-
Bay R 1531
-
Befiradol
-
BMY-14802
-
Cannabidiol
-
Dimemebfe
-
Dopamine
-
Ebalzotan
-
Eltoprazine
-
Enciprazine
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
-
F-11,461
-
F-12826
-
F-13714
-
F-14679
-
F-15063
-
F-15,599
-
Flesinoxan
-
Flibanserin
-
Flumexadol
-
Hypidone
-
Lesopitron
-
LY-293284
-
LY-301317
-
mCPP
-
MKC-242
-
Naluzotan
-
NBUMP
-
Osemozotan
-
Oxaflozane
-
Pardoprunox
-
Piclozotan
-
Rauwolscine
-
Repinotan
-
Roxindole
-
RU-24,969
-
S-14,506
-
S-14671
-
S-15535
-
Sarizotan
-
Serotonin (5-HT)
-
SSR-181507
-
Sunepitron
-
Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
-
TGBA01AD
-
U-92,016-A
-
Urapidil
-
Vilazodone
-
Xaliproden
-
Yohimbine
|
-
Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
-
AV965
-
Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)
-
BMY-7,378
-
CSP-2503
-
Dotarizine
-
Ergolines (e.g., metergoline)
-
FCE-24379
-
Flopropione
-
GR-46611
-
Isamoltane
-
Lecozotan
-
Mefway
-
Metitepine (methiothepin)
-
MIN-117 (WF-516)
-
MPPF
-
NAN-190
-
Robalzotan
-
S-15535
-
SB-649,915
-
SDZ 216-525
-
Spiperone
-
Spiramide
-
Spiroxatrine
-
UH-301
-
WAY-100135
-
WAY-100635
-
Xylamidine
|
|
|
---|
5-HT1B |
-
Agonists: Anpirtoline
-
CGS-12066A
-
CP-93129
-
CP-94253
-
CP-122,288
-
CP-135807
-
Eltoprazine
-
Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
-
mCPP
-
RU-24,969
-
Serotonin (5-HT)
-
Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
-
TFMPP
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
-
Vortioxetine
|
|
|
|
---|
5-HT1D |
-
Agonists: CP-122,288
-
CP-135807
-
CP-286601
-
Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
-
GR-46611
-
L-694247
-
L-772405
-
mCPP
-
PNU-109291
-
PNU-142633
-
Serotonin (5-HT)
-
TGBA01AD
-
Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)
|
|
|
|
---|
5-HT1E |
|
---|
5-HT1F |
|
---|
|
---|
5-HT2 |
5-HT2A |
-
Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
-
2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
-
2C-B-FLY
-
2CB-Ind
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
-
AL-34662
-
AL-37350A
-
Bromo-DragonFLY
-
Dimemebfe
-
DMBMPP
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Efavirenz
-
Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
-
Flumexadol
-
IHCH-7113
-
Jimscaline
-
Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
-
O-4310
-
Oxaflozane
-
PHA-57378
-
PNU-22394
-
PNU-181731
-
RH-34
-
SCHEMBL5334361
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., BZP, quipazine, TFMPP)
-
Serotonin (5-HT)
-
TCB-2
-
TFMFly
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
-
Antagonists: 5-I-R91150
-
5-MeO-NBpBrT
-
AC-90179
-
Adatanserin
-
Altanserin
-
Antihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)
-
AMDA
-
Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
-
Chlorprothixene
-
Cinanserin
-
CSP-2503
-
Deramciclane
-
Dotarizine
-
Eplivanserin
-
Ergolines (e.g., amesergide, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
-
Fananserin
-
Flibanserin
-
Glemanserin
-
Irindalone
-
Ketanserin
-
KML-010
-
Landipirdine
-
LY-393558
-
mCPP
-
Medifoxamine
-
Metitepine (methiothepin)
-
MIN-117 (WF-516)
-
Naftidrofuryl
-
Nantenine
-
Nelotanserin
-
Opiranserin (VVZ-149)
-
Pelanserin
-
Phenoxybenzamine
-
Pimavanserin
-
Pirenperone
-
Pizotifen
-
Pruvanserin
-
Rauwolscine
-
Ritanserin
-
Roluperidone
-
S-14671
-
Sarpogrelate
-
Serotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)
-
SR-46349B
-
TGBA01AD
-
Teniloxazine
-
Temanogrel
-
Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
-
Tricyclic antidepressants (e.g., amitriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)
-
Volinanserin
-
Xylamidine
-
Yohimbine
|
|
|
---|
5-HT2B |
-
Agonists: 4-Methylaminorex
-
Aminorex
-
Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
-
BW-723C86
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
-
Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
-
Piperazines (e.g., TFMPP)
-
PNU-22394
-
Ro60-0175
-
Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
-
Antagonists: Agomelatine
-
Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N-desalkylquetiapine (norquetiapine), N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)
-
Cyproheptadine
-
EGIS-7625
-
Ergolines (e.g., amesergide, bromocriptine, lisuride, LY-53857, LY-272015, mesulergine)
-
Ketanserin
-
LY-393558
-
mCPP
-
Metadoxine
-
Metitepine (methiothepin)
-
Pirenperone
-
Pizotifen
-
Propranolol
-
PRX-08066
-
Rauwolscine
-
Ritanserin
-
RS-127445
-
Sarpogrelate
-
SB-200646
-
SB-204741
-
SB-206553
-
SB-215505
-
SB-221284
-
SB-228357
-
SDZ SER-082
-
Tegaserod
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
-
Trazodone
-
Typical antipsychotics (e.g., chlorpromazine)
-
TIK-301
-
Yohimbine
|
|
|
---|
5-HT2C |
-
Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
-
5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
-
α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
-
A-372159
-
AL-38022A
-
Alstonine
-
CP-809101
-
Dimemebfe
-
DOx (e.g., DOB, DOC, DOI, DOM)
-
Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
-
Flumexadol
-
Lorcaserin
-
MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
-
MK-212
-
ORG-12962
-
ORG-37684
-
Oxaflozane
-
PHA-57378
-
Phenethylamines (e.g., lophophine, mescaline)
-
Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
-
PNU-22394
-
PNU-181731
-
Ro60-0175
-
Ro60-0213
-
Serotonin (5-HT)
-
Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
-
Vabicaserin
-
WAY-629
-
WAY-161503
-
YM-348
|
-
Antagonists: Adatanserin
-
Agomelatine
-
Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
-
Captodiame
-
CEPC
-
Cinanserin
-
Cyproheptadine
-
Deramciclane
-
Desmetramadol
-
Dotarizine
-
Eltoprazine
-
Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
-
Etoperidone
-
Fluoxetine
-
FR-260010
-
Irindalone
-
Ketanserin
-
Ketotifen
-
Latrepirdine (dimebolin)
-
Medifoxamine
-
Metitepine (methiothepin)
-
Nefazodone
-
Pirenperone
-
Pizotifen
-
Propranolol
-
Ritanserin
-
RS-102221
-
S-14671
-
SB-200646
-
SB-206553
-
SB-221284
-
SB-228357
-
SB-242084
-
SB-243213
-
SDZ SER-082
-
Tedatioxetine
-
Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
-
TIK-301
-
Tramadol
-
Trazodone
-
Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
-
Xylamidine
|
|
|
---|
|
---|
5-HT3–7 |
5-HT3 |
-
Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)
-
m-CPBG
-
Phenylbiguanide
-
Piperazines (e.g., BZP, mCPP, quipazine)
-
RS-56812
-
Serotonin (5-HT)
-
SR-57227
-
SR-57227A
-
Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
-
Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
-
YM-31636
|
-
Antagonists: Alosetron
-
Anpirtoline
-
Arazasetron
-
AS-8112
-
Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
-
Azasetron
-
Batanopride
-
Bemesetron (MDL-72222)
-
Bupropion
-
Cilansetron
-
CSP-2503
-
Dazopride
-
Dolasetron
-
Galanolactone
-
Granisetron
-
Hydroxybupropion
-
Lerisetron
-
Memantine
-
Ondansetron
-
Palonosetron
-
Ramosetron
-
Renzapride
-
Ricasetron
-
Tedatioxetine
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
-
Thujone
-
Tropanserin
-
Tropisetron
-
Typical antipsychotics (e.g., loxapine)
-
Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
-
Vortioxetine
-
Zacopride
-
Zatosetron
|
|
|
---|
5-HT4 |
|
---|
5-HT5A |
|
---|
5-HT6 |
-
Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
-
Hypidone
-
Serotonin (5-HT)
-
Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, ST-1936, tryptamine)
-
WAY-181187
-
WAY-208466
|
-
Antagonists: ABT-354
-
Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
-
AVN-101
-
AVN-211
-
AVN-322
-
AVN-397
-
BGC20-760
-
BVT-5182
-
BVT-74316
-
Cerlapirdine
-
EGIS-12,233
-
GW-742457
-
Idalopirdine
-
Ketanserin
-
Landipirdine
-
Latrepirdine (dimebolin)
-
Masupirdine
-
Metitepine (methiothepin)
-
MS-245
-
PRX-07034
-
Ritanserin
-
Ro 04-6790
-
Ro 63-0563
-
SB-258585
-
SB-271046
-
SB-357134
-
SB-399885
-
SB-742457
-
Tetracyclic antidepressants (e.g., amoxapine, mianserin)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
-
Typical antipsychotics (e.g., chlorpromazine, loxapine)
|
|
|
---|
5-HT7 |
|
-
Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
-
Butaclamol
-
DR-4485
-
EGIS-12,233
-
Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
-
JNJ-18038683
-
Ketanserin
-
LY-215,840
-
Metitepine (methiothepin)
-
Ritanserin
-
SB-258719
-
SB-258741
-
SB-269970
-
SB-656104
-
SB-656104A
-
SB-691673
-
SLV-313
-
SLV-314
-
Spiperone
-
SSR-181507
-
Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
-
Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
-
Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
-
Vortioxetine
|
|
|
---|
|
---|
|