UGT2B4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | UGT2B4, HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11, UDP glucuronosyltransferase family 2 member B4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600067; MGI: 1919023; HomoloGene: 130717; GeneCards: UGT2B4; OMA:UGT2B4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.[5][6][7]
UGT2B4 is mainly involved in the glucuronidationofhyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone.[8]
The expression of the UGT2B4 enzyme is upregulated by the farnesoid X receptor (FXR), a nuclear receptor which is activated by bile acids.[9] These same bile acids are substrates for the UGT2B4 enzyme. Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it. |