Contents

HAS1

Protein-coding gene in the species Homo sapiens

HAS1
Identifiers
Aliases	HAS1, HAS, hyaluronan synthase 1
External IDs	OMIM: 601463; MGI: 106590; HomoloGene: 1165; GeneCards: HAS1; OMA:HAS1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,713,112 bp[1] End 51,723,991 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.2|17 10.53 cM Start 18,063,585 bp[2] End 18,075,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle parietal pleura vena cava germinal epithelium right ovary synovial joint left ovary synovial membrane pericardium middle temporal gyrus Top expressed in ankle joint ankle genital tubercle tail of embryo embryo facial motor nucleus trachea aortic valve submandibular gland ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity hyaluronan synthase activity protein binding identical protein binding Cellular component cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process cell adhesion negative regulation of fibroblast migration hyaluronan biosynthetic process cellular response to platelet-derived growth factor stimulus extracellular matrix assembly glycosaminoglycan biosynthetic process extracellular polysaccharide biosynthetic process estrous cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3036 15116 Ensembl ENSG00000105509 ENSMUSG00000003665 UniProt Q92839 Q61647 RefSeq (mRNA) NM_001297436 NM_001523 NM_008215 RefSeq (protein) NP_001284365 NP_001514 NP_032241 Location (UCSC) Chr 19: 51.71 – 51.72 Mb Chr 17: 18.06 – 18.08 Mb PubMed search [3] [4]
Wikidata
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Hyaluronan synthase 1 is an enzyme that in humans is encoded by the HAS1 gene.^[5][6]

Structure[edit]

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-transporter into the extracellular space.^[7]

Function[edit]

It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.^[6]

References[edit]

Further reading[edit]