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Contents

   



(Top)
  


1 Mechanism of action  




2 References  













Vosaroxin







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From Wikipedia, the free encyclopedia
  

Vosaroxin
Names
Preferred IUPAC name

7-[(3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Other names

Voreloxin

Identifiers

CAS Number

3D model (JSmol)
ChEBI
ChemSpider

PubChem CID
UNII

CompTox Dashboard (EPA)

  • InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1

    Key: XZAFZXJXZHRNAQ-STQMWFEESA-N

  • InChI=1/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1

    Key: XZAFZXJXZHRNAQ-STQMWFEEBT

  • CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O

Properties

Chemical formula

 C18H19N5O4S
Molar mass 401.44 g·mol−1
Density 1.5±0.1 g/cm3
Pharmacology

ATC code

 L01XX53 (WHO)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Vosaroxin (AG-7352, SPC-595, SNS 595, voreloxin) is a topoisomerase II inhibitor causing site-selective DNA damage. It is under phase III clinical trial investigation for acute myelogenous leukemia (AML) and ovarian cancer sponsored by Sunesis.[1]

Mechanism of action

[edit]

Vosaroxin is a naphthyridine analog of the anticancer quinolone derivatives (AQDs), a class of compounds that has not been used previously for the treatment of cancer. Topoisomerase II enzymes are essential for the survival of eukaryotic cells. Vosaroxin hinders the reunion of topoisomerase II-induced double-strand breaks at selective sites in DNA, resulting in G2 arrest and cell death by apoptosis.[2]

References

[edit]
  1. ^ "Vosaroxin". Selleck Chemicals.
  • ^ "Vosaroxin (Formerly Voreloxin)". Sunesis.


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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Vosaroxin&oldid=1230934872"
    Categories: 
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