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{{short description|Class of enzymes, carbon–carbon lyases}} |
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'''Carboxy-lyases''', also known as '''decarboxylases''', are [[carbon-carbon lyases|carbon–carbon]] [[lyases]] that add or remove a [[carboxyl]] group from [[organic compound]]s. |
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'''Carboxy-lyases''', also known as '''decarboxylases''', are [[carbon-carbon lyases|carbon–carbon]] [[lyases]] that add or remove a [[carboxyl]] group from [[organic compound]]s. These [[enzyme]]s catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.<ref>{{cite journal |doi=10.1016/S0167-4838(98)00076-4|title=Application of α-keto acid decarboxylases in biotransformations|year=1998|last1=Iding |first1=H.|last2=Siegert|first2=P.|last3=Mesch|first3=K.|last4=Pohl|first4=M.|journal=Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology|volume=1385|issue=2|pages=307–322|pmid=9655924}}</ref> |
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These [[enzyme]]s catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.<ref>http://www.expasy.org/cgi-bin/get-entries?KW=Decarboxylase</ref> |
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==Classification and nomenclature== |
==Classification and nomenclature== |
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Carboxy-lyases are categorized under [[Enzyme Commission number|EC number]] 4.1.1.<ref>http://www.biochem.ucl.ac.uk/bsm/enzymes/ec4/ec01/ec01/index.html</ref> |
Carboxy-lyases are categorized under [[Enzyme Commission number|EC number]] 4.1.1.<ref>{{cite web|url=http://www.biochem.ucl.ac.uk/bsm/enzymes/ec4/ec01/ec01/index.html|title=E.C.4.1.1.- Carboxy-lyases.|website=www.biochem.ucl.ac.uk|access-date=2006-11-08|archive-url=https://web.archive.org/web/20061013132003/http://www.biochem.ucl.ac.uk/bsm/enzymes/ec4/ec01/ec01/index.html#|archive-date=2006-10-13|url-status=dead}}</ref> |
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Usually, they are named after the substrate whose [[decarboxylation]] they [[catalyze]], for example [[ |
Usually, they are named after the substrate whose [[decarboxylation]] they [[catalyze]], for example [[pyruvate decarboxylase]] catalyzes the decarboxylation of [[pyruvate]]. |
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==Examples== |
==Examples== |
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* [[Aromatic-L-amino-acid decarboxylase]] |
* [[Aromatic-L-amino-acid decarboxylase]] |
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* [[Glutamate decarboxylase]] |
* [[Glutamate decarboxylase]] |
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* [[Uridine monophosphate synthetase]] |
* [[Uridine monophosphate synthetase]] |
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* [[Uroporphyrinogen III decarboxylase]] |
* [[Uroporphyrinogen III decarboxylase]] |
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* enoyl-CoA carboxylases/reductases (ECRs)<ref>{{cite journal |doi=10.1126/science.aah5237|title=A synthetic pathway for the fixation of carbon dioxide in vitro|year=2016|last1=Schwander|first1=Thomas|last2=Schada von Borzyskowski|first2=Lennart|last3=Burgener|first3=Simon|last4=Cortina|first4=Niña Socorro|last5=Erb|first5=Tobias J.|journal=Science|volume=354|issue=6314|pages=900–904|pmid=27856910|pmc=5892708|bibcode=2016Sci...354..900S}}</ref> |
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==See also== |
==See also== |
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==References== |
==References== |
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{{reflist |
{{reflist}} |
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==External links== |
==External links== |
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* {{MeshName|Carboxy-Lyases}} |
* {{MeshName|Carboxy-Lyases}} |
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{{Carbon-carbon lyases}} |
{{Carbon-carbon lyases}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 4.1.1|*]] |
[[Category:EC 4.1.1|*]] |
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Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.[1]
Carboxy-lyases are categorized under EC number 4.1.1.[2] Usually, they are named after the substrate whose decarboxylation they catalyze, for example pyruvate decarboxylase catalyzes the decarboxylation of pyruvate.
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This EC 4.1 enzyme-related article is a stub. You can help Wikipedia by expanding it. |
