Content that violates any copyrights will be deleted. Encyclopedic content must be verifiable through citations to reliable sources.
You are about to undo an edit. Please check the comparison below to verify that this is what you want to do, then publish the changes below to finish undoing the edit. If you are undoing an edit that is not vandalism, explain the reason in the edit summary. Do not use the default message only. |
| Latest revision | Your text | ||
| Line 91: | Line 91: | ||
=== PACE study (2011) === |
=== PACE study (2011) === |
||
In 2011, ''The Lancet'' published a study by the UK-based "PACE trial management group", which reported success with graded exercise therapy and cognitive behavioural therapy for [[chronic fatigue syndrome]];<ref>{{cite journal |vauthors=White PD |display-authors=etal |year=2011 |title=Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial |journal=The Lancet |volume=377 |issue=9768 |pages=823–836 |doi=10.1016/S0140-6736(11)60096-2|pmid=21334061 |pmc=3065633}}</ref> a follow-up study was published in ''Lancet Psychiatry'' in 2015.<ref>{{cite journal|last1=Sharpe|first1=M|last2=Goldsmith|first2=KA|last3=Johnson|first3=AL|last4=Chalder|first4=T|last5=Walker|first5=J|last6=White|first6=PD|title=Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.|journal=The Lancet Psychiatry|date=December 2015|volume=2|issue=12|pages=1067–74|pmid=26521770|doi=10.1016/s2215-0366(15)00317-x|url=https://kclpure.kcl.ac.uk/ws/files/70539057/PACE_long_term_follow_up_2015_04_25.pdf|doi-access=free|access-date=16 August 2019|archive-date=24 June 2019|archive-url=https://web.archive.org/web/20190624101505/https://kclpure.kcl.ac.uk/ws/files/70539057/PACE_long_term_follow_up_2015_04_25.pdf|url-status=live}}</ref> The studies attracted criticism from some patients and researchers, especially with regard to data analysis that was |
In 2011, ''The Lancet'' published a study by the UK-based "PACE trial management group", which reported success with graded exercise therapy and cognitive behavioural therapy for [[chronic fatigue syndrome]];<ref>{{cite journal |vauthors=White PD |display-authors=etal |year=2011 |title=Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial |journal=The Lancet |volume=377 |issue=9768 |pages=823–836 |doi=10.1016/S0140-6736(11)60096-2|pmid=21334061 |pmc=3065633}}</ref> a follow-up study was published in ''Lancet Psychiatry'' in 2015.<ref>{{cite journal|last1=Sharpe|first1=M|last2=Goldsmith|first2=KA|last3=Johnson|first3=AL|last4=Chalder|first4=T|last5=Walker|first5=J|last6=White|first6=PD|title=Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.|journal=The Lancet Psychiatry|date=December 2015|volume=2|issue=12|pages=1067–74|pmid=26521770|doi=10.1016/s2215-0366(15)00317-x|url=https://kclpure.kcl.ac.uk/ws/files/70539057/PACE_long_term_follow_up_2015_04_25.pdf|doi-access=free|access-date=16 August 2019|archive-date=24 June 2019|archive-url=https://web.archive.org/web/20190624101505/https://kclpure.kcl.ac.uk/ws/files/70539057/PACE_long_term_follow_up_2015_04_25.pdf|url-status=live}}</ref> The studies attracted criticism from some patients and researchers, especially with regard to data analysis that was different from that described in the original protocol.<ref name="SlateCFS">{{cite web|url=https://slate.com/technology/2015/11/chronic-fatigue-pace-trial-is-flawed-should-be-reanalyzed.html|title=Hope for Chronic Fatigue Syndrome: The debate over this mysterious disease is suddenly shifting|last=Rehmeyer|first=Julie|date=13 November 2015|website=[[Slate (magazine)|Slate]]|url-status=live|archive-url=https://web.archive.org/web/20190815121158/https://slate.com/technology/2015/11/chronic-fatigue-pace-trial-is-flawed-should-be-reanalyzed.html|archive-date=15 August 2019}}</ref> In a 2015 ''[[Slate (magazine)|Slate]]'' article, biostatistician Bruce Levin of [[Columbia University]] was quoted saying "The Lancet needs to stop [[Wagon fort#Overview|circling the wagons]] and be open", and that "one of the tenets of good science is transparency"; while Ronald Davis of [[Stanford University]] said: "the Lancet should step up to the plate and pull that paper".<ref name=SlateCFS/> Horton defended ''The Lancet'''s publication of the trial and called the critics: "a fairly small, but highly organized, very vocal and very damaging group of individuals who have, I would say, actually hijacked this agenda and distorted the debate so that it actually harms the overwhelming majority of patients."<ref name=SlateCFS/> |
||
Starting in 2011, critics of the studies filed Freedom of Information Act requests to get access to the authors' primary data, in order to learn what the trial's results would have been under the original protocol. In 2016, some of the data was released, which allowed calculation of results based on the original protocol and found that additional treatment led to no significant improvement in recovery rates over the control |
Starting in 2011, critics of the studies filed Freedom of Information Act requests to get access to the authors' primary data, in order to learn what the trial's results would have been under the original protocol. In 2016, some of the data was released, which allowed calculation of results based on the original protocol and found that additional treatment led to no significant improvement in recovery rates over the control condition.<ref name=WilshireCFS>{{cite journal |last1=Wilshire|first1=C|last2=Kindlon|first2=T|last3=Matthees|first3=A|last4=McGrath|first4=S|year=2016 |title=Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial |journal=Fatigue: Biomedicine, Health & Behavior |volume=5 |issue=1 |pages=43–56|doi=10.1080/21641846.2017.1259724|doi-access=free}}</ref><ref>{{cite web|url=https://www.nytimes.com/2017/03/18/opinion/sunday/getting-it-wrong-on-chronic-fatigue-syndrome.html|title=Getting It Wrong on Chronic Fatigue Syndrome|last1=Rehmeyer|first1=Julie|last2=Tuller|first2=David|date=18 March 2017|work=[[The New York Times]]|type=editorial|url-access=limited|url-status=live|archive-url=https://archive.today/20191028073736/https://www.nytimes.com/2017/03/18/opinion/sunday/getting-it-wrong-on-chronic-fatigue-syndrome.html|archive-date=28 October 2019}}</ref> |
||
=== Metastudy on the use of hydroxychloroquine and chloroquine (2020) === |
=== Metastudy on the use of hydroxychloroquine and chloroquine (2020) === |
||
Copy and paste: – — ° ′ ″ ≈ ≠ ≤ ≥ ± − × ÷ ← → · § Cite your sources: <ref></ref>
{{}} {{{}}} | [] [[]] [[Category:]] #REDIRECT [[]] <s></s> <sup></sup> <sub></sub> <code></code> <pre></pre> <blockquote></blockquote> <ref></ref> <ref name="" /> {{Reflist}} <references /> <includeonly></includeonly> <noinclude></noinclude> {{DEFAULTSORT:}} <nowiki></nowiki> <!-- --> <span class="plainlinks"></span>
Symbols: ~ | ¡ ¿ † ‡ ↔ ↑ ↓ • ¶ # ∞ ‹› «» ¤ ₳ ฿ ₵ ¢ ₡ ₢ $ ₫ ₯ € ₠ ₣ ƒ ₴ ₭ ₤ ℳ ₥ ₦ № ₧ ₰ £ ៛ ₨ ₪ ৳ ₮ ₩ ¥ ♠ ♣ ♥ ♦ 𝄫 ♭ ♮ ♯ 𝄪 © ® ™
Latin: A a Á á À à  â Ä ä Ǎ ǎ Ă ă Ā ā à ã Å å Ą ą Æ æ Ǣ ǣ B b C c Ć ć Ċ ċ Ĉ ĉ Č č Ç ç D d Ď ď Đ đ Ḍ ḍ Ð ð E e É é È è Ė ė Ê ê Ë ë Ě ě Ĕ ĕ Ē ē Ẽ ẽ Ę ę Ẹ ẹ Ɛ ɛ Ǝ ǝ Ə ə F f G g Ġ ġ Ĝ ĝ Ğ ğ Ģ ģ H h Ĥ ĥ Ħ ħ Ḥ ḥ I i İ ı Í í Ì ì Î î Ï ï Ǐ ǐ Ĭ ĭ Ī ī Ĩ ĩ Į į Ị ị J j Ĵ ĵ K k Ķ ķ L l Ĺ ĺ Ŀ ŀ Ľ ľ Ļ ļ Ł ł Ḷ ḷ Ḹ ḹ M m Ṃ ṃ N n Ń ń Ň ň Ñ ñ Ņ ņ Ṇ ṇ Ŋ ŋ O o Ó ó Ò ò Ô ô Ö ö Ǒ ǒ Ŏ ŏ Ō ō Õ õ Ǫ ǫ Ọ ọ Ő ő Ø ø Œ œ Ɔ ɔ P p Q q R r Ŕ ŕ Ř ř Ŗ ŗ Ṛ ṛ Ṝ ṝ S s Ś ś Ŝ ŝ Š š Ş ş Ș ș Ṣ ṣ ß T t Ť ť Ţ ţ Ț ț Ṭ ṭ Þ þ U u Ú ú Ù ù Û û Ü ü Ǔ ǔ Ŭ ŭ Ū ū Ũ ũ Ů ů Ų ų Ụ ụ Ű ű Ǘ ǘ Ǜ ǜ Ǚ ǚ Ǖ ǖ V v W w Ŵ ŵ X x Y y Ý ý Ŷ ŷ Ÿ ÿ Ỹ ỹ Ȳ ȳ Z z Ź ź Ż ż Ž ž ß Ð ð Þ þ Ŋ ŋ Ə ə
Greek: Ά ά Έ έ Ή ή Ί ί Ό ό Ύ ύ Ώ ώ Α α Β β Γ γ Δ δ Ε ε Ζ ζ Η η Θ θ Ι ι Κ κ Λ λ Μ μ Ν ν Ξ ξ Ο ο Π π Ρ ρ Σ σ ς Τ τ Υ υ Φ φ Χ χ Ψ ψ Ω ω {{Polytonic|}}
Cyrillic: А а Б б В в Г г Ґ ґ Ѓ ѓ Д д Ђ ђ Е е Ё ё Є є Ж ж З з Ѕ ѕ И и І і Ї ї Й й Ј ј К к Ќ ќ Л л Љ љ М м Н н Њ њ О о П п Р р С с Т т Ћ ћ У у Ў ў Ф ф Х х Ц ц Ч ч Џ џ Ш ш Щ щ Ъ ъ Ы ы Ь ь Э э Ю ю Я я ́
IPA: t̪ d̪ ʈ ɖ ɟ ɡ ɢ ʡ ʔ ɸ β θ ð ʃ ʒ ɕ ʑ ʂ ʐ ç ʝ ɣ χ ʁ ħ ʕ ʜ ʢ ɦ ɱ ɳ ɲ ŋ ɴ ʋ ɹ ɻ ɰ ʙ ⱱ ʀ ɾ ɽ ɫ ɬ ɮ ɺ ɭ ʎ ʟ ɥ ʍ ɧ ʼ ɓ ɗ ʄ ɠ ʛ ʘ ǀ ǃ ǂ ǁ ɨ ʉ ɯ ɪ ʏ ʊ ø ɘ ɵ ɤ ə ɚ ɛ œ ɜ ɝ ɞ ʌ ɔ æ ɐ ɶ ɑ ɒ ʰ ʱ ʷ ʲ ˠ ˤ ⁿ ˡ ˈ ˌ ː ˑ ̪ {{IPA|}}
Wikidata entities used in this page
Pages transcluded onto the current version of this page (help):
This page is a member of 14 hidden categories (help):
