Jump to content
 







Main menu
    


Navigation  


●Main page
 ●Contents
 ●Current events
 ●Random article
 ●About Wikipedia
 ●Contact us
 ●Donate
  



Contribute  


●Help
 ●Learn to edit
 ●Community portal
 ●Recent changes
 ●Upload file
  







Search  

































●Create account

●Log in
 









●Create account
 ● Log in
  



Pages for logged out editors learn more  


●Contributions
 ●Talk
  


















Contents

   



(Top)
  


1 Pharmacology  




2 Legal status  


2.1  Australia  




2.2  Canada  




2.3  China  




2.4  United States  






3 See also  




4 References  













4-Fluoromethamphetamine






●Français
 ●Српски / srpski
 ●Srpskohrvatski / српскохрватски
  
Edit links
  








●Article
 ●Talk
  
















●Read
 ●Edit
 ●View history
  







Tools
    


Actions  


●Read
 ●Edit
 ●View history
  



General  


●What links here
 ●Related changes
 ●Upload file
 ●Special pages
 ●Permanent link
 ●Page information
 ●Cite this page
 ●Get shortened URL
 ●Download QR code
 ●Wikidata item
  



Print/export  


●Download as PDF
 ●Printable version
  



In other projects  


●Wikimedia Commons
  















Appearance
    

 





From Wikipedia, the free encyclopedia
  
(Redirected from 4-FMA)
4-Fluoromethamphetamine
Ball-and-stick model of the 4-fluoromethamphetamine molecule
Legal status
Legal status
  • AU: S9 (Prohibited substance)
  • CA: Schedule I[1]
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • UK: Class A
  • US: Unscheduled
    • Identifiers

    • (RS)-1-(4-Fluorophenyl)-N-methylpropan-2-amine

    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    ECHA InfoCard100.254.220 Edit this at Wikidata
    Chemical and physical data
    FormulaC10H14FN
    Molar mass167.227 g·mol−1
    3D model (JSmol)

    • Fc1ccc(cc1)CC(NC)C

    • InChI=1S/C10H14FN/c1-8(12-2)7-9-3-5-10(11)6-4-9/h3-6,8,12H,7H2,1-2H3 checkY

    • Key:YCWZPIHKUYZTFM-UHFFFAOYSA-N checkY

     ☒NcheckY (what is this?)  (verify)

    4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine. It has been reported to be sold as a designer drug, but little is known about its pharmacology or toxicology.[2] It was first detected from legal highs sold in Japan in 2006 and became illegal to sell or to possess for the purpose of distribution (although not to simply possess for personal use) in Japan in 2008.[3] It was initially reported to be contained as an ingredient in some of the range of party pills sold internationally by the Israeli company Neorganics from around 2006 onwards, but this was later shown to be incorrect and this ingredient was eventually identified as the closely related compound 2-fluoromethamphetamine.[4]

    Pharmacology[edit]

    4-FMA is a CYP450 inhibitor. It reduces the metabolism of methamphetamine, which has the effect of increasing its potency, duration and systemic toxicity while also reducing its cellular toxicity.[5]

    Legal status[edit]

    Australia[edit]

    4-FMA is considered a Schedule 9 substance in Australia under the Poisons Standard (October 2015).[6] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[6]

    Canada[edit]

    As of 1996, 4-FMA is a controlled substance in Canada, due to being an analog of methamphetamine.[1]

    China[edit]

    As of October 2015 4-FMA is a controlled substance in China.[7]

    United States[edit]

    As a close analog of scheduled controlled substance,[2] sale or possession of 4-FMA could be potentially be prosecuted under the Federal Analogue Act.[8]

    See also[edit]

  • 3-Fluoromethamphetamine (3-FMA)
  • 3-Fluoroethamphetamine (3-FEA)
  • 4-Fluoroamphetamine (4-FA)
  • 4-Fluoromethcathinone (4-FMC)
  • 4-Methylmethamphetamine (4-MMA)
  • 4-Methoxymethamphetamine (PMMA)
  • Fenisorex

    • References[edit]

    1. ^ a b Branch, Legislative Services (2022-03-31). "Consolidated federal laws of Canada, Controlled Drugs and Substances Act". laws-lois.justice.gc.ca. Archived from the original on 2022-06-11. Retrieved 2022-08-11.
  • ^ a b Rösner P, Quednow B, Girreser U, Junge T (March 2005). "Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs)". Forensic Science International. 148 (2–3): 143–56. doi:10.1016/j.forsciint.2004.05.003. PMID 15639609.
  • ^ Nagashima M, Seto T, Takahashi M, Suzuki J, Yasuda I (2006). "Spectrum Data of the 3rd Governor-designated Drugs and the Analyses of Uncontrolled Drugs Purchased" (PDF). Tokyo Metropolitan Institute of Public Health Annual Report (in Japanese). 57: 109–113. Archived from the original (PDF) on 2011-07-22. Retrieved 2007-12-10.
  • ^ Camilleri A, Johnston MR, Brennan M, Davis S, Caldicott DG (April 2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone". Forensic Science International. 197 (1–3): 59–66. doi:10.1016/j.forsciint.2009.12.048. PMID 20074881.
  • ^ Cherner M, Bousman C, Everall I, Barron D, Letendre S, Vaida F, et al. (September 2010). "Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings". Journal of the International Neuropsychological Society. 16 (5): 890–901. doi:10.1017/S1355617710000779. PMC 3543816. PMID 20727252.
  • ^ a b "Poisons Standard". Federal Register of Legislation. Australian Government. October 2015.
  • ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  • ^ "Federal Controlled Substance Analogue Act Summary". Erowid Analog Law Vault.

    • Retrieved from "https://en.wikipedia.org/w/index.php?title=4-Fluoromethamphetamine&oldid=1181402375"
    Categories: 
    ●Designer drugs
     ●Methamphetamines
     ●Euphoriants
     ●Serotonin-norepinephrine-dopamine releasing agents
     ●Fluoroarenes
     ●Entactogens and empathogens
     Hidden categories: 
    ●CS1 Japanese-language sources (ja)
     ●CS1 Chinese-language sources (zh)
     ●Articles with short description
     ●Short description is different from Wikidata
     ●Drugs with non-standard legal status
     ●Articles with changed CASNo identifier
     ●ECHA InfoCard ID from Wikidata
     ●Articles without EBI source
     ●Chemical pages without DrugBank identifier
     ●Articles without KEGG source
     ●Drugs missing an ATC code
     ●Drugboxes which contain changes to verified fields
     ●Drugboxes which contain changes to watched fields
      


    ●This page was last edited on 22 October 2023, at 20:42 (UTC).
    ●Text is available under the Creative Commons Attribution-ShareAlike License 4.0; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization.


    ●Privacy policy
    ●About Wikipedia
    ●Disclaimers
    ●Contact Wikipedia
    ●Code of Conduct
    ●Developers
    ●Statistics
    ●Cookie statement
    ●Mobile view


    Wikimedia Foundation
    Powered by MediaWiki