Contents

ATF1

Protein-coding gene in humans

ATF1
Identifiers
Aliases	ATF1, EWS-FUS/ATF-1, TREB36, activating transcription factor 1
External IDs	OMIM: 123803; MGI: 3037720; HomoloGene: 3790; GeneCards: ATF1; OMA:ATF1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 50,763,710 bp[1] End 50,821,162 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A5 Start 52,885,578 bp[2] End 52,886,387 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Skeletal muscle tissue of rectus abdominis parietal pleura amniotic fluid biceps brachii Skeletal muscle tissue of biceps brachii visceral pleura trabecular bone palpebral conjunctiva Achilles tendon Top expressed in embryo lens testicle striatum of neuraxis liver heart cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific protein-containing complex binding Cellular component ATF1-ATF4 transcription factor complex transcription regulator complex nucleoplasm nucleus Biological process regulation of transcription, DNA-templated response to organic cyclic compound transcription, DNA-templated positive regulation of DNA replication positive regulation of neuron projection development response to cobalt ion positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 466 100040260 Ensembl ENSG00000123268 ENSMUSG00000080968 UniProt P18846 n/a RefSeq (mRNA) NM_005171 XM_036162179 RefSeq (protein) NP_005162 n/a Location (UCSC) Chr 12: 50.76 – 50.82 Mb Chr X: 52.89 – 52.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.^[5]

Clinical significance[edit]

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.^[5][6]

See also[edit]

• Activating transcription factor

Interactions[edit]

ATF1 has been shown to interact with:

• BRCA1,^[7]
• CSNK2A2,^[8]
• CSNK2A1,^[8] and
• EWS.^[9]

References[edit]

Further reading[edit]

External links[edit]

• ATF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ATF1 genome location and ATF1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.