Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.[5]
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.[6]
IRF2 has been shown to interact with BRD7,[7] EP300[8] and PCAF.[8][9]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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1irf: INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
1irg: INTERFERON REGULATORY FACTOR-2 DNA BINDING DOMAIN, NMR, 20 STRUCTURES
2irf: CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
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