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1 References  














Apolizumab






العربية
 

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From Wikipedia, the free encyclopedia
 


Apolizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetHLA-DR beta
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
 ☒NcheckY (what is this?)  (verify)

Apolizumab is a humanized monoclonal antibody intended for use in hematologic cancers.[1][2] Development was abandoned in 2005, because of toxic effects and lack of efficacy in humans. The observed dose limiting toxic effects were aseptic meningitis and hemolytic uremia.[3]

References

[edit]
  1. ^ Bayes M, Rabasseda X, Prous JR (November 2003). "Gateways to clinical trials". Methods and Findings in Experimental and Clinical Pharmacology. 25 (9): 747–771. PMID 14685303.
  • ^ Rech J, Repp R, Rech D, Stockmeyer B, Dechant M, Niedobitek G, et al. (October 2006). "A humanized HLA-DR antibody (hu1D10, apolizumab) in combination with granulocyte colony-stimulating factor (filgrastim) for the treatment of non-Hodgkin's lymphoma: a pilot study". Leukemia & Lymphoma. 47 (10): 2147–2154. doi:10.1080/10428190600757944. PMID 17071489. S2CID 24080973.
  • ^ Lin TS, Stock W, Xu H, Phelps MA, Lucas MS, Guster SK, et al. (December 2009). "A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia". Leukemia & Lymphoma. 50 (12): 1958–1963. doi:10.3109/10428190903186486. PMC 8166408. PMID 19860603. S2CID 22328921.
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  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Apolizumab&oldid=1178198900"

    Categories: 
    Drugs not assigned an ATC code
    Monoclonal antibodies
    Abandoned drugs
    Monoclonal antibody stubs
    Antineoplastic and immunomodulating drug stubs
    Hidden categories: 
    Articles with short description
    Short description matches Wikidata
    Articles with changed CASNo identifier
    Chemicals that do not have a ChemSpider ID assigned
    Articles without EBI source
    Chemical pages without DrugBank identifier
    Articles without InChI source
    Drugs with no legal status
    Drugboxes which contain changes to verified fields
    Drugs that are a monoclonal antibody
    All stub articles
     



    This page was last edited on 2 October 2023, at 04:29 (UTC).

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