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Contents

   



(Top)
 


1 Health  





2 List of known casomorphins (non-exhaustive)  



2.1  β-Casomorphins 13  





2.2  Bovine β-casomorphins 14  





2.3  Bovine β-casomorphin 14, amide  





2.4  Bovine β-casomorphin 5  





2.5  Bovine β-casomorphin 7  





2.6  Bovine β-casomorphin 8  







3 References  














Casomorphin






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From Wikipedia, the free encyclopedia
 


Bovine β-casomorphin 7, a casomorphin, has seven amino acids in its peptide sequence.

Casomorphin is an opioid peptide (protein fragment) derived from the digestion of the milk protein casein.[1]

Health[edit]

Digestive enzymes can break casein down into peptides that have some biological activity in cells and in laboratory animals though conclusive causal effects on humans have not been established.[1]

Although research has shown high rates of use of complementary and alternative therapies for children with autism, including gluten and/or casein exclusion diets, as of 2008 there was a lack of evidence that these diets had any effect.[2]

If opioid peptides breach the intestinal barrier, typically linked to permeability and constrained biosynthesis of dipeptidyl peptidase-4 (DPP4), they can attach to opioid receptors. Elucidation requires a systemic framework that acknowledges that public-health effects of food-derived opioids are complex with varying genetic susceptibility and confounding factors, together with system-wide interactions and feedbacks.[3]

List of known casomorphins (non-exhaustive)[edit]

β-Casomorphins 1–3[edit]

Bovine β-casomorphins 1–4[edit]

Bovine β-casomorphin 1–4, amide[edit]

Also known as morphiceptin

Bovine β-casomorphin 5[edit]

Bovine β-casomorphin 7[edit]

Bovine β-casomorphin 8[edit]

(Note: There is also a form of bovine β-casomorphin 8 that has histidine instead of proline in position 8, depending on whether it is derived from A1 (His) or A2 (Pro) beta-casein.)

References[edit]

  1. ^ a b European Food Safety Authority. 1 February 2009 Review of the potential health impact of β-casomorphins and related peptides
  • ^ Millward, C; Ferriter, M; Calver, S; Connell-Jones, G (2008). "Gluten- and casein-free diets for autistic spectrum disorder". Cochrane Database of Systematic Reviews (2): CD003498. doi:10.1002/14651858.CD003498.pub3. PMC 4164915. PMID 18425890.
  • ^ Keith, Bernard Woodford (2021). "Casomorphins and Gliadorphins Have Diverse Systemic Effects Spanning Gut, Brain and Internal Organs". Int J Environ Res Public Health. 18 (15): 7911. doi:10.3390/ijerph18157911. PMC 8345738. PMID 34360205.

  • Retrieved from "https://en.wikipedia.org/w/index.php?title=Casomorphin&oldid=1225263358"

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    This page was last edited on 23 May 2024, at 10:55 (UTC).

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