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Contents

   



(Top)
  


1 See also  




2 References  













2,5-Dimethoxy-4-trifluoromethylamphetamine






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From Wikipedia, the free encyclopedia
  
(Redirected from DOTFM)
2,5-Dimethoxy-4-trifluoromethylamphetamine
Clinical data
Other names2,5-Dimethoxy-4-trifluoromethylamphetamine
Legal status
Legal status
  • UK: Class A
    • Identifiers

    • (RS)-1-[2,5-Dimethoxy-4-(trifluoromethyl)phenyl]propan-2-amine

    CAS Number
    PubChem CID
    ChemSpider
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC12H16F3NO2
    Molar mass263.260 g·mol−1
    3D model (JSmol)

    • FC(F)(F)c1cc(OC)c(cc1OC)CC(N)C

    • InChI=1S/C12H16F3NO2/c1-7(16)4-8-5-11(18-3)9(12(13,14)15)6-10(8)17-2/h5-7H,4,16H2,1-3H3 checkY

    • Key:WPGOTSORDNBMHP-UHFFFAOYSA-N checkY

     ☒NcheckY (what is this?)  (verify)

    2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogueof2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5-HT2A and 5-HT2C receptors.[1] In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1]

    See also

    [edit]

    References

    [edit]
    1. ^ a b c Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF (1994). "1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist". Journal of Medicinal Chemistry. 37 (25): 4346–4351. doi:10.1021/jm00051a011. PMID 7996545.

    Retrieved from "https://en.wikipedia.org/w/index.php?title=2,5-Dimethoxy-4-trifluoromethylamphetamine&oldid=1187505044"
    Categories: 
    ●Substituted amphetamines
     ●Trifluoromethyl compounds
     ●2,5-Dimethoxyphenethylamines
     ●Substances discovered in the 1990s
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